Differential Expression of Hedgehog and Snail in Cutaneous Fibrosing Disorders: Implications for Targeted Inhibition.

abstract：:HMB45 is a melanoma-specific monoclonal antibody that has found widespread use in diagnostic pathology. Recent reports, however, have suggested that this antibody may cross-react with a small number of carcinomas and other epithelial cells. The authors tested the hypothesis that these latter reports represent examples...

journal_title：American journal of clinical pathology

authors： Bonetti F,Pea M,Martignoni G,Mombello A,Colombari R,Zamboni G,Scarpa A,Piubello Q,Bacchi CE,Gown AM

更新日期：1991-04-01 00:00:00

abstract：:The significance of the human immunodeficiency virus (HIV) in the small intestinal lamina propria in patients with the acquired immune deficiency syndrome or conditions related to that syndrome who have chronic diarrhea and malabsorption is unclear. To investigate this issue, upper endoscopy (after a 12- to 16-hour fa...

journal_title：American journal of clinical pathology

authors： Ehrenpreis ED,Patterson BK,Brainer JA,Yokoo H,Rademaker AW,Glogowski W,Noskin GA,Craig RM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:B-lymphoblastic leukemia (B-LBL) arising in patients with chronic lymphocytic leukemia (CLL) is exceedingly rare and poorly characterized. METHODS:We describe four patients with CLL and concurrent or subsequent B-LBL diagnosed by morphologic, immunophenotypic, cytogenetic, and molecular analysis and reviewe...

journal_title：American journal of clinical pathology

authors： Chakhachiro Z,Yin CC,Abruzzo LV,Aladily TN,Barron LL,Banks HE,Thomas DA,Keating M,Medeiros LJ,Huh YO

更新日期：2015-08-01 00:00:00

abstract：:Fresh open lung biopsy material from 57 patients was incubated with fluoresceinated complement and immunoglobulin antisera. An indirect immunofluorescent assay using neonatal lung as substrate was conducted as well. Direct immunofluorescent patterns could be categorized into interalveolar septal capillary deposition, ...

journal_title：American journal of clinical pathology

authors： Magro CM,Morrison C,Pope-Harman A,Rothrauff SK,Ross P Jr

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Pure erythroid leukemia (PEL) is exceptionally rare in the pediatric setting. Four pediatric PEL cases with t(1;16)(p31;q24) NFIA-CBFA2T3 were reported previously. We present a case of an infant with PEL presenting with erythroblastic sarcoma and harboring a novel t(1;8)(p31.3;q21.3) NFIA-RUNX1T1 fusion dete...

journal_title：American journal of clinical pathology

authors： King RL,Siaghani PJ,Wong K,Edlefsen K,Shane L,Howard MT,Reichard KK,Mai M,Viswanatha DS,Greipp PT,Goble TA,Ruiz M,Hara H

更新日期：2020-12-14 00:00:00

abstract：:Immunohistochemical analysis of oral lichen-planus-like eruption (LPLE) in graft-versus-host disease (GVHD) using monoclonal antibodies (MoAbs) was performed on five patients after allogeneic bone marrow transplantation (BMT) for leukemia. In the mucosal lesions of LPLE in GVHD, the major population of infiltrated lym...

journal_title：American journal of clinical pathology

authors： Fujii H,Ohashi M,Nagura H

更新日期：1988-02-01 00:00:00

abstract：:Clinical data and histologic sections of the liver, including immunohistochemical studies for hepatitis B surface and core antigens, were reviewed in 42 autopsy cases of the acquired immune deficiency syndrome (AIDS). Hepatomegaly, elevation of serum transaminases, and mild elevation of alkaline phosphatase were commo...

journal_title：American journal of clinical pathology

authors： Glasgow BJ,Anders K,Layfield LJ,Steinsapir KD,Gitnick GL,Lewin KJ

更新日期：1985-05-01 00:00:00

abstract：:Nineteen patients with acute nonlymphocytic leukemia were found to have a pericentric inversion of chromosome 16. All were classified as having acute myelomonocytic leukemia (M4) according to French-American-British Cooperative Group (FAB) criteria. Consistent abnormalities of marrow eosinophils were present. In 15 of...

journal_title：American journal of clinical pathology

authors： Bitter MA,Le Beau MM,Larson RA,Rosner MC,Golomb HM,Rowley JD,Vardiman JW

更新日期：1984-06-01 00:00:00

abstract：:The thymus was the site of a true histiocytic lymphoma. Immunohistochemical demonstration of lysozyme and alpha-1-antitrypsin in the tumor cells indicated the histiocytic nature of the tumor. Five fetal and five adult thymus glands were studied for the presence and distribution of true histiocytic cells. Histiocytes w...

journal_title：American journal of clinical pathology

authors： Szporn AH,Dikman S,Jagirdar J

更新日期：1984-12-01 00:00:00

abstract：:Encephalitozoon (Septata) intestinalis affects AIDS patients with CD4 counts <100/microL, causing intestinal and disseminated disease. It must be distinguished from the more common intestinal microsporidian, Enterocytozoon bieneusi, and from other microsporidia of extraintestinal tissues, such as Encephalitozoon helle...

journal_title：American journal of clinical pathology

authors： Chu P,West AB

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVES:High-grade serous carcinoma (HGSC) is the most common ovarian malignancy. The role of cytopathology in obtaining tissue diagnosis before institution of neoadjuvant chemotherapy (NACT) was evaluated. METHODS:All histopathology-proven HGSC specimens between 2015 and 2018 with prior cytopathologic diagnosis by...

journal_title：American journal of clinical pathology

authors： Bansal A,Srinivasan R,Rohilla M,Sundaram A,Rai B,Rajwanshi A,Suri V,Saha SC,Gupta N,Gupta P,Dey P

更新日期：2020-06-08 00:00:00

abstract：:A simple assay based on molecular light scattering was developed to detect soluble immune complexes. In this assay the percentage of relative light scattering (%RLS) caused by complexes in buffer containing polyethylene glycol 6000 (PEG) was measured with a laser nephelometer. In low concentrations of PEG (3%-5%), IgG...

journal_title：American journal of clinical pathology

authors： Koethe SM,Melton HE,Jendrzejczak Z

更新日期：1980-12-01 00:00:00

abstract：:A column chromatographic method for the simultaneous single-eluate isolation of CPK-MB and LDH 1,2 has been evaluated. The method is rapid in that the entire isolation is completed in less than an hour and subsequent analysis can be performed using presently available spectrophotometric methods and reagents without th...

journal_title：American journal of clinical pathology

authors： Lederer WH,Gerstbrein HL,McClintock WC

更新日期：1976-08-01 00:00:00

abstract：:The cases of three patients who had clinical courses and hematologic data consistent with plasma-cell leukemia or a terminal leukemic phase of multiple myeloma are presented. A double Bence Jones protein was demonstrated in the urine of two of the patients. Immunoelectrophoresis and immunofluorescence studies demonstr...

journal_title：American journal of clinical pathology

authors： Pedraza MA

更新日期：1975-09-01 00:00:00

abstract：:The relationship between immunohistochemically measured membranous expression of erbB-2 oncoprotein and prognosis in breast cancer is controversial, and the relationship between cytoplasmic positivity and prognosis has been minimally investigated. The clinical course of 300 women with infiltrating breast carcinoma, wh...

journal_title：American journal of clinical pathology

authors： Keshgegian AA,Cnaan A

更新日期：1997-10-01 00:00:00

abstract：:Immunoperoxidase technics were used to examine the immunoglobulin content of sections of pulmonary tissue from two typical cases of lymphomatoid granulomatosis and two cases of pneumonic processes initially diagnosed as lymphomatoid granulomatosis but representing different processes on review. Both "typical" cases an...

journal_title：American journal of clinical pathology

authors： Bender BL,Jaffe R

更新日期：1980-01-01 00:00:00

abstract：:Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile cutaneous mastocytosis) to highly aggressive neoplasms like mast cell leukemia. Princi...

journal_title：American journal of clinical pathology

authors： Horny HP

更新日期：2009-09-01 00:00:00

abstract：:The nephrotic syndrome has long been recognized as a hypercoagulable state. Arterial thrombosis is a rare complication of the syndrome. Diuretics and steroids, standard treatment for exacerbations, have been implicated as contributing to the development of arterial thrombosis. The authors present the pathologic, clini...

journal_title：American journal of clinical pathology

authors： Zimmerman RL,Novek S,Chen JT,Roggli V

更新日期：1994-02-01 00:00:00

abstract：:A 76-year-old white man previous diagnosed as having Waldenstrom's macroglobulinemia continued with persistent fevers and sweats for two and a half years. Recently, repeated automated differentials during 11 days of hospitalization failed to note any intracellular inclusions in the RBCs. Blood sent to the Microbiology...

journal_title：American journal of clinical pathology

authors： Bruckner DA,Garcia LS,Shimizu RY,Goldstein EJ,Murray PM,Lazar GS

更新日期：1985-04-01 00:00:00

abstract：:Four media, Eagle's minimal essential medium with 10% fetal bovine serum (MEM/FBS), tryptic soy broth (TSB), 2-SP, and 4-SP, were compared for their ability to maintain the viability of Chlamydia trachomatis at 4 degrees C, -20 degrees C, -70 degrees C, and -176 degrees C (liquid nitrogen) over a 1-week period. 2-SP m...

journal_title：American journal of clinical pathology

authors： Aarnaes SL,Peterson EM,De La Maza LM

更新日期：1984-02-01 00:00:00

abstract：:Differential characterization of the "reticulum cell" in lymphoreticular neoplasms. Am J Clin Pathol. 64: 171-179, 1975. The term "reticulum cell" is confusing, having been applied to the cells involved in many hematopoietic neoplasms, such as reticulum-cell sarcoma, histiocytic medullary reticulosis, leukemic reticul...

journal_title：American journal of clinical pathology

authors： Yam LT,Tavassoli M,Jacobs P

更新日期：1975-08-01 00:00:00

abstract：:Tissue specimens from a series of 46 hepatic tumors occurring in young female oral contraceptive users were tested for alpha1-antitrypsin deposition, utilizing immunocytochemical and histochemical methods. In two instances serum alpha1-antitrypsin phenotyping was also performed. Immunoreactive alpha1-antitrypsin depos...

journal_title：American journal of clinical pathology

authors： Palmer PE,Christopherson WM,Wolfe HJ

更新日期：1977-12-01 00:00:00

abstract：:To study the histogenesis of and determine the most useful markers for diagnosing anaplastic thyroid carcinoma (ATC), 32 cases, including 2 with numerous osteoclast-like cells, were stained with a battery of antibodies to epithelial (keratin, epithelial membrane antigen [EMA], carcinoembryonic antigen [CEA]), mesenchy...

journal_title：American journal of clinical pathology

authors： Ordóñez NG,El-Naggar AK,Hickey RC,Samaan NA

更新日期：1991-07-01 00:00:00

abstract：:Hyperparathyroidism may occasionally present as a neck mass resulting from cystic change in a parathyroid adenoma. We report an unusual instance of hyperparathyroidism presenting as a palpable, but asymptomatic hyperplastic parathyroid gland cyst. We conclude that hyperplastic parathyroid glands may undergo cystic deg...

journal_title：American journal of clinical pathology

authors： Fallon MD,Haines JW,Teitelbaum SL

更新日期：1982-01-01 00:00:00

abstract：:Staphylococcus epidermidis is among the most common organisms isolated from blood cultures. Conversely, it is rarely a well-documented cause of natural-valve endocarditis. However, several authors have reported series of patients with the clinical picture of endocarditis and S. epidermidis bacteremia. Most of these ca...

journal_title：American journal of clinical pathology

authors： Littenberg B,Cooper B,Levitz R

更新日期：1987-03-01 00:00:00

abstract：:We describe the development and testing of a novel pre-sign-out quality assurance tool for case diagnoses that allows for the random review of a percentage of cases by a second pathologist before case verification and release of the final report. The tool incorporates the ability to record and report levels of diagnos...

journal_title：American journal of clinical pathology

authors： Owens SR,Dhir R,Yousem SA,Kelly SM,Piccoli A,Wiehagen L,Lassige K,Parwani AV

更新日期：2010-06-01 00:00:00

abstract：:Results of a comparison of the diagnostic efficacy of percutaneous needle biopsy of the parietal pleura with that of cytologic examination of pleural fluid sediment obtained concurrently from 166 patients with benign or cancerous pleural disorders are reported. Of 44 patients with confirmatory evidence of cancer invol...

journal_title：American journal of clinical pathology

authors： Frist B,Kahan AV,Koss LG

更新日期：1979-07-01 00:00:00

abstract：:The ongoing collaborative relationship between a pathology department and the vendor of its laboratory information system is vitally important because of the strategic importance of the laboratory information system in managing the information product of the department. Laboratory information system vendors are value-...

journal_title：American journal of clinical pathology

authors： Friedman BA,Mitchell W

更新日期：1992-03-01 00:00:00

abstract：:We studied the histologic and multiparameter flow cytometry (MFC) features of 12 cases of angioimmunoblastic T-cell lymphoma (AITL), 13 of mature T-cell lymphoma, and 25 control cases of reactive lymphoid hyperplasia to evaluate the role of CD10 in the differential diagnosis of peripheral T-cell lymphomas (PTCLs). A c...

journal_title：American journal of clinical pathology

authors： Stacchini A,Demurtas A,Aliberti S,Francia di Celle P,Godio L,Palestro G,Novero D

更新日期：2007-11-01 00:00:00

abstract：:The case of a 23-year-old woman with a primary small cell carcinoma of the endometrium is reported. The light microscopic features were similar to those of small cell carcinoma of the lung and those of the uterine cervix. Electron microscopy revealed cytoplasmic neurosecretory type granules and indistinct cell junctio...

journal_title：American journal of clinical pathology

authors： Kumar NB

更新日期：1984-01-01 00:00:00