Abstract:
:Nineteen patients with acute nonlymphocytic leukemia were found to have a pericentric inversion of chromosome 16. All were classified as having acute myelomonocytic leukemia (M4) according to French-American-British Cooperative Group (FAB) criteria. Consistent abnormalities of marrow eosinophils were present. In 15 of the 19 patients, the number of eosinophils was increased. Morphologic abnormalities of eosinophils were present in all patients, the most striking being the presence of large basophilic staining granules in 18 of the 19 patients. In most cases we also found a population of cells with morphologic features of both eosinophils and monocytes. Eosinophils showed atypical cytochemical reactions with PAS in ten of ten cases studied, with naphthol ASD Chloroacetate in ten of ten cases, and with combined naphthol ASD Chloroacetate esterase- chlorazol fast pink in seven of nine cases tested. The presence of inv(16) defines a distinct subset of ANLL with consistent morphologic and cytochemical features.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Bitter MA,Le Beau MM,Larson RA,Rosner MC,Golomb HM,Rowley JD,Vardiman JWdoi
10.1093/ajcp/81.6.733subject
Has Abstractpub_date
1984-06-01 00:00:00pages
733-41issue
6eissn
0002-9173issn
1943-7722journal_volume
81pub_type
杂志文章abstract::A primary hepatic tumor with histologic features suggestive of carcinoid tumor is reported, and six previously reported cases reviewed. Tumor cells contained electron dense secretory granules with an average diameter 150-200 nm which demonstrated positive argyrophilic reactions. On immunohistochemistry, chromogranin A...
journal_title:American journal of clinical pathology
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更新日期:1988-04-01 00:00:00
abstract::In a case of secondary syphilis with gastric involvement, the clinical history and roentgenographic and gastroscopic examiniations initially suggested an infiltrative malignant neoplasm. However, macroscopic and histologic examination of the partial gastrectomy specimen demonstrated an erosive, inflammatory lesion. Su...
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journal_title:American journal of clinical pathology
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更新日期:1989-04-01 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1988-04-01 00:00:00
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更新日期:1982-10-01 00:00:00
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更新日期:1999-06-01 00:00:00
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更新日期:2007-03-01 00:00:00
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更新日期:1980-03-01 00:00:00
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更新日期:1986-03-01 00:00:00
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更新日期:2010-04-01 00:00:00
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更新日期:2008-04-01 00:00:00