Expression of p63 in thymomas and normal thymus.

Abstract:

:The p63 gene, a member of the p53 family, is an epithelial marker expressed in embryonic ectoderm, breast myoepithelium, prostate, oral epithelium, epidermis, and urothelium. The DeltaN-p63 isoforms of p63, which are believed to behave as oncogenes, are expressed in squamous cell carcinoma, basal cell carcinoma, and transitional cell carcinoma. Only a few authors have looked for p63 expression in thymomas and normal thymus. We, therefore, thought of undergoing such a search by taking advantage of our archival material. We studied 66 cases of thymoma (1 type A, 8 type AB, 12 type B1, 19 type B2, 12 type B3, and 14 type C/thymic carcinoma) and 10 specimens of normal human thymus arranged in tissue microarrays. All thymomas (including thymic carcinomas) were positive for p63 regardless of type. Most of the epithelial cells of the normal thymus were also positive for this marker.

journal_name

Am J Clin Pathol

authors

Dotto J,Pelosi G,Rosai J

doi

10.1309/2GAYKPDDM85P2VEW

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

415-20

issue

3

eissn

0002-9173

issn

1943-7722

pii

606K406070125172

journal_volume

127

pub_type

杂志文章
  • The LAST guidelines in clinical practice: implementing recommendations for p16 use.

    abstract:OBJECTIVES:To determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared p16 use and follow-up data before and after implementation of the guidelines. METHODS:We reviewed all cervical biopsy specimens diagnosed by two...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPUXLP7XD8OQYY

    authors: Clinton LK,Miyazaki K,Ayabe A,Davis J,Tauchi-Nishi P,Shimizu D

    更新日期:2015-12-01 00:00:00

  • Improving patient safety by repeating (read-back) telephone reports of critical information.

    abstract::Reducing the rate of avoidable errors is crucial to patient safety. Telephone calls with misunderstood critical results constitute one area in which opportunities for improvement exist. The aviation industry has dealt with this issue by requiring pilots to repeat instructions received from the air traffic controller. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/9DYM-6R0T-M830-U95Q

    authors: Barenfanger J,Sautter RL,Lang DL,Collins SM,Hacek DM,Peterson LR

    更新日期:2004-06-01 00:00:00

  • DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections.

    abstract::Hydatidiform moles can be subclassified based on their ploidy. In general, complete moles are diploid, and partial moles are triploid. The standard method for the determination of DNA content is flow cytometric analysis. In this study, the authors investigated whether static cytometric analysis with the CAS 200 Image ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.451

    authors: Barclay ID,Dabbagh L,Babiak J,Poppema S

    更新日期:1993-10-01 00:00:00

  • Biospecimen Collection During the COVID-19 Pandemic.

    abstract:OBJECTIVES:Millions of biospecimens will be collected during the coronavirus disease 2019 (COVID-19) pandemic. As learned from severe acute respiratory syndrome (SARS), proper biospecimen handling is necessary to prevent laboratory-related infections. METHODS:Centers for Disease Control and Prevention and World Health...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/aqaa171

    authors: Lankes HA,Makhlouf H

    更新日期:2021-01-04 00:00:00

  • Sysmex SE-9000 hematology analyzer: performance evaluation on leukocyte differential counts using an NCCLS H20-A protocol. National Committee for Clinical Laboratory Standards.

    abstract::We evaluated the performance (ie, imprecision, inaccuracy, and analytic sensitivity) of the Sysmex SE-9000 commercial hematology analyzer (TOA Medical Electronics, Kobe, Japan) on differential leukocyte counts according to the National Committee for Clinical Laboratory Standards H20-A protocol. The results obtained we...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.6.674

    authors: Buttarello M,Bulian P,Temporin V,Rizzotti P

    更新日期:1997-12-01 00:00:00

  • Carcinoma of the small intestine associated with transmural ileitis (Crohn's disease).

    abstract::A case of adenocarcinoma of the small bowel arising in pre-existing transmural ileitis (Crohn's disease) is reported and 28 previously reported cases are reviewed. Carcinoma associated with transmural enteritis occurs more often in the distal ileum, in younger patients, and in more males than expected from published d...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/63.2.168

    authors: Savage RA,Farmer RG,Hawk WA

    更新日期:1975-02-01 00:00:00

  • Proliferative activity in non-Hodgkin's lymphomas. A comparison of the bromodeoxyuridine labeling index with PCNA immunostaining and quantitative image analysis.

    abstract::Cellular proliferation is being evaluated as an independent prognostic indicator in a variety of tumors, including non-Hodgkin's lymphomas (NHL). Although the labeling index (LI), using either tritiated thymidine or monoclonal antibodies to bromodeoxyuridine, is considered to be the gold standard of cell kinetic measu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.6.668

    authors: Sebo TJ,Roche PC,Witzig TE,Kurtin PJ

    更新日期:1993-06-01 00:00:00

  • Method precision and frequent causes of errors observed in point-of-care glucose testing: a proficiency testing program perspective.

    abstract:OBJECTIVES:Method imprecision, error rates, and explanatory causes that were identified in the Institute for Quality Management in Healthcare point-of-care (POC) glucose proficiency testing (PT) program were assessed in comparison with results obtained from laboratory glucose PT surveys. METHODS:POC and laboratory glu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPP5YS2MVSKBYY

    authors: Aslan B,Stemp J,Yip P,Gun-Munro J

    更新日期:2014-12-01 00:00:00

  • Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.

    abstract::Micropapillary lung adenocarcinoma (MPA) has been reported as an aggressive variant of adenocarcinoma, frequently manifesting at high stage with a poor prognosis. We analyzed the clinical and molecular profile of 15 primary MPAs for K-ras, EGFR, and BRAF mutations and performed fluorescence in situ hybridization for E...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPBS85VJEOBPDO

    authors: De Oliveira Duarte Achcar R,Nikiforova MN,Yousem SA

    更新日期:2009-05-01 00:00:00

  • Use of a probe to repeat sequence of the Y chromosome for detection of host cells in peripheral blood of bone marrow transplant recipients.

    abstract::In situ hybridization for the Y chromosome (Y-ISH) was used to identify residual host cells in the peripheral blood of 51 recipients of sex-mismatched allogeneic marrow not depleted of T cells following conditioning with high-dose cyclophosphamide and total body irradiation (TBI). One patient who rejected the graft sh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.2.201

    authors: Przepiorka D,Thomas ED,Durnam DM,Fisher L

    更新日期:1991-02-01 00:00:00

  • Noninvasive monitoring of hemoglobin. The effects of WBC counts on measurement.

    abstract::The efficacy of a noninvasive hemoglobin monitoring device (Astrin, Sysmex, Kobe, Japan) was evaluated for healthy volunteers and for patients with hematologic disorders. At the same time, the effects of WBC counts on noninvasive monitoring were studied by clinical evaluation and in ex vivo experiments. The hemoglobin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/61AN-J1XV-3MW8-78YP

    authors: Saigo K,Imoto S,Hashimoto M,Mito H,Moriya J,Chinzei T,Kubota Y,Numada S,Ozawa T,Kumagai S

    更新日期:2004-01-01 00:00:00

  • Assessment of a critical limit protocol for point-of-care glucose testing.

    abstract::A critical limit protocol requiring that all point of care glucose meter readings > 22.2 mmol/L (400 mg/dL) and < 2.2 mmol/L (40 mg/dL) be immediately confirmed by the laboratory was assessed. A total of 193 (2%) of 9,523 glucose meter determinations (63 patients) were > 22.2 or < 2.2 mmol/L. One hundred twenty-two (6...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.3.390

    authors: Lum G

    更新日期:1996-09-01 00:00:00

  • Management by objectives for the academic medical center.

    abstract::Management by Objectives (MBO) is results-oriented, participatory management, which is appropriate for the current era of keen competition for resources. MBO was installed in the author's institution in clinical laboratory divisions meeting prerequisites and fit the system to the local management environment. The resu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.6.738

    authors: Kost GJ

    更新日期:1986-12-01 00:00:00

  • Comparison of disagreement and amendment rates by tissue type and diagnosis: identifying cases for directed blinded review.

    abstract::We sought to determine whether a group of cases that was relatively high in disagreements and subsequent amendments could be identified and targeted for blinded review. During a 4-year period, 8,916 surgical pathology and nongynecologic cytology cases were subjected to blinded review; of these, there were 616 disagree...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DH4U-0KT6-QB01-KR55

    authors: Renshaw AA,Gould EW

    更新日期:2006-11-01 00:00:00

  • Giant forms of Blastomyces dermatitidis in the pulmonary lesions of blastomycosis. Potential confusion with Coccidioides immitis.

    abstract::Typical yeast-phase cells of Blastomyces dermatitidis have a characteristic appearance in tissue sections. Fungal morphologic variation occurs infrequently in the lesions of blastomycosis, yet it can complicate the differential diagnosis, particularly if fresh tissue is not available for microbiologic culture. The aut...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.4.575

    authors: Watts JC,Chandler FW,Mihalov ML,Kammeyer PL,Armin AR

    更新日期:1990-04-01 00:00:00

  • Hodgkin disease associated with T-cell non-Hodgkin lymphomas: case reports and review of the literature.

    abstract::Non-Hodgkin lymphoma (NHL) is more likely to develop in patients with Hodgkin disease (HD) than in the general population. Although reports of synchronous or metachronous HD and NHL are not uncommon in the literature, the biologic relationship of these 2 malignant neoplasms often is unclear. A larger-than-expected fra...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/W1GW-43HT-793U-F86R

    authors: Brown JR,Weng AP,Freedman AS

    更新日期:2004-05-01 00:00:00

  • The blood counts and lactate dehydrogenase levels in thrombotic thrombocytopenic purpura (TTP).

    abstract::The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.5.700

    authors: Crowley JP,Metzger JB,L'Europa RA

    更新日期:1983-11-01 00:00:00

  • Chronic myelogenous leukemia, BCR-ABL1+.

    abstract::Session 1 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology focused on chronic myelogenous leukemia, BCR-ABL1+ (CML). CML is a myeloproliferative neoplasm arising at the level of a pluripotent stem cell and consistently associated with the BCR-ABL1 fusion gene. CML most ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPUN89CXERVOVH

    authors: Vardiman JW

    更新日期:2009-08-01 00:00:00

  • Comparison of three methods for measuring factor VIII levels in plasma.

    abstract::We compared 1-stage clot-based, chromogenic, and immunoassay methods for measuring factor VIII in plasma with a focus on the measurement of elevated levels of factor VIII. The chromogenic assay showed the best interassay imprecision for factor VIII levels near 150 IU/dL. The best correlation was between the 1-stage cl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/C8T8-YNB4-G3W4-5PRF

    authors: Chandler WL,Ferrell C,Lee J,Tun T,Kha H

    更新日期:2003-07-01 00:00:00

  • Signet ring cell lymphoma. A report of a case and review of the literature.

    abstract::A case of signet ring cell lymphoma, a rare variant of follicular center cell lymphoma, is presented with a review of 20 other such lymphomas previously reported in the English literature. The histologic, immunocytologic, and electron microscopic features are described with speculation as to the possible relationship ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.358

    authors: Silberman S,Fresco R,Steinecker PH

    更新日期:1984-03-01 00:00:00

  • Lymphoepithelioma-Like Carcinoma of the Uterine Cervix: A Pathologic Study of Eight Cases With Emphasis on the Association With Human Papillomavirus.

    abstract:Objectives:Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor. The goal of this study was to evaluate a series of cases of cervical LELC and to investigate possible association with human papillomavirus (HPV) and/or Epstein-Barr virus (EBV). Methods:Immunohistochemistry for p63, p16, human l...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy130

    authors: Pinto A,Huang M,Nadji M

    更新日期:2019-01-07 00:00:00

  • Misleading hepatitis C serology following administration of intravenous immunoglobulin.

    abstract::Intravenous immunoglobulin (IVIG) is a blood derivative that is being evaluated for the prevention and treatment of numerous disorders. Recent studies have suggested beneficial effects from the prophylactic administration of IVIG to very-low-birth-weight neonates. A disadvantage of such therapy is misleading infectiou...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.3.327

    authors: Nixon RR,Smith SA,Johnson RL,Pillers DA

    更新日期:1994-03-01 00:00:00

  • The role of aspiration biopsy cytology in the diagnosis of pulmonary tuberculosis.

    abstract::The experience at one institution concerning the diagnosis of pulmonary tuberculosis by aspiration biopsy is reviewed. Twelve cases in which acid-fast bacilli were identified in pulmonary aspiration material are reported. The cytologic findings were confirmed by microbiologic culture in nine cases. The advantages of u...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/83.6.719

    authors: Robicheaux G,Moinuddin SM,Lee LH

    更新日期:1985-06-01 00:00:00

  • Significance of leukocyte alkaline phosphatase in hairy cell leukemia.

    abstract::Peripheral blood samples of 23 patients who had hairy cell leukemia were examined for leukocyte alkaline phosphatase scores. Leukocyte alkaline phosphatase levels were elevated in seventeen patients (74%), were normal in six (26%), and were not decreased in any patient. The mean leukocyte alkaline phosphatase score wa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.3.297

    authors: Aiba M,Raffa PP,Katayama I

    更新日期:1980-09-01 00:00:00

  • Pathology and medical malpractice. Academic and trainee empirical review of cases by State of Texas physicians.

    abstract:OBJECTIVES:This study examines whether the assumptions that pathologists understand the medical malpractice negligence rule and have a clear single standard of care are reasonable. METHODS:Two hundred eighty-one Texas academic pathologists and trainees were presented 10 actual pathology malpractice cases from publicly...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQLK63BQFDODF

    authors: Allen TC,Stafford M,Liang BA

    更新日期:2014-04-01 00:00:00

  • Acute lymphocytic leukemia manifesting as splenic rupture.

    abstract::Pathologic rupture of the spleen is a rare phenomenon in acute lymphocytic leukemia, and its mechanism is unknown. This complication has been seen almost exclusively in men, and at ages much older than those of the majority of patients who have this leukemia; these unusual features are also unexplained. A case of acut...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.1.118

    authors: Johnson CS,Rosen PJ,Sheehan WW

    更新日期:1979-07-01 00:00:00

  • Fatal acute spontaneous endometritis resulting from Clostridium sordelli.

    abstract::Intrauterine clostridial infections have historically been associated with puerperal sepsis, often subsequent to instrumented abortions. Isolated reports have been associated with a malignant neoplasm or degenerating leiomyoma, most often after instrumentation, radiation therapy, or chemotherapy. In these cases, well-...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.1.104

    authors: Hogan SF,Ireland K

    更新日期:1989-01-01 00:00:00

  • Primary Ki-1 (anaplastic large cell) lymphoma of the brain and spinal cord.

    abstract::The authors report a case of primary Ki-1 lymphoma of the brain. The patient was a 4 1/2-year-old black girl who presented with a 4- and 5-day history of headaches, nausea, vomiting, neck stiffness, and difficulty in walking. Computed tomography (CT) scan of the brain showed two discrete densities in the left occipita...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.4.496

    authors: Havlioglu N,Manepalli A,Galindo L,Sotelo-Avila C,Grosso L

    更新日期:1995-04-01 00:00:00

  • A new Mycobacterium species causing diffuse lepromatous leprosy.

    abstract::Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purifie...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPP72FJZZRRVMM

    authors: Han XY,Seo YH,Sizer KC,Schoberle T,May GS,Spencer JS,Li W,Nair RG

    更新日期:2008-12-01 00:00:00

  • Rat antikeratin monoclonal antibodies are specific for stratified squamous epithelia.

    abstract::Seven monoclonal antibodies of rat origin were generated against human epidermal keratins and were assayed by immunoblot and by immunoperoxidase staining of frozen sections from various human epithelial tissues. By immunoblotting, the antibodies recognized two different subsets of high molecular weight cytokeratin pol...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.3.315

    authors: Chin NW,Lai BT,Lanks KW

    更新日期:1988-03-01 00:00:00