Lymphoepithelioma-Like Carcinoma of the Uterine Cervix: A Pathologic Study of Eight Cases With Emphasis on the Association With Human Papillomavirus.

Abstract:

Objectives:Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare tumor. The goal of this study was to evaluate a series of cases of cervical LELC and to investigate possible association with human papillomavirus (HPV) and/or Epstein-Barr virus (EBV). Methods:Immunohistochemistry for p63, p16, human leukocyte antigen-D related (HLA-DR), and B-cell lymphoma 2 (BCL-2); in situ hybridization (ISH) for EBV and HPV; and polymerase chain reaction (PCR) genotyping were performed. Mismatch repair (MMR) studies and PD-L1 status were obtained. Results:We found eight cases of LELC. Tumors demonstrated sheets of cells containing vesicular nuclei, amphiphilic cytoplasm, and dense peri- and intratumoral lymphocytic infiltrates. All tumors stained for p63, p16, and HLA-DR; two also stained for BCL-2. When combining ISH and PCR results, seven tumors were HPV positive; they were all Epstein-Barr encoding region negative. All cases were MMR intact, and most overexpressed PD-L1. Conclusions:This study shows that cervical LELCs are associated with HPV and not EBV.

journal_name

Am J Clin Pathol

authors

Pinto A,Huang M,Nadji M

doi

10.1093/ajcp/aqy130

subject

Has Abstract

pub_date

2019-01-07 00:00:00

pages

231-239

issue

2

eissn

0002-9173

issn

1943-7722

pii

5129871

journal_volume

151

pub_type

杂志文章
  • The morphologic and immunophenotypic assessment of the lymphocytosis accompanying Bordetella pertussis infection.

    abstract::Bordetella pertussis (Bp) infection in infants and young children can be associated with a significant increase in small lymphocytes with convoluted and cleaved nuclei (SLCCN) in the peripheral blood (PB). Buffy coat smears were studied that were prepared from the PB of 11 children with documented Bp infection, whose ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.6.809

    authors: Kubic VL,Kubic PT,Brunning RD

    更新日期:1991-06-01 00:00:00

  • Comparison of two commercially available selective media to screen for vancomycin-resistant enterococci.

    abstract::Campylobacter medium (CAMPY, Becton Dickinson [BD] Microbiology Systems, Cockeysville, MD) and Vancomycin Screen Agar (VSA, BD) were compared for their ability to screen for vancomycin-resistant Enterococcus (VRE) from primary plates. A microdilution minimal inhibitory concentration (MIC) assay (Pasco, BD) served as t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/TWY5-04QE-9KV0-52MT

    authors: Shigei J,Tan G,Shiao A,de la Maza LM,Peterson EM

    更新日期:2002-01-01 00:00:00

  • Detection of bacteremia with the BACTEC 16B resin blood culture medium.

    abstract::A new blood culture medium (16B) containing adsorbent and cationic exchange resins has become available for use with the BACTEC instrument (Johnston Laboratories, Towson, MD). Its purpose is to enhance the detection of bacteremia through binding of antimicrobials. The performance of the BACTEC 16B resin medium was com...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.5.643

    authors: DeGirolami PC,Eichelberger K,Siegel J

    更新日期:1984-05-01 00:00:00

  • The status and distance of cone biopsy margins as a predictor of excision adequacy for endocervical adenocarcinoma in situ.

    abstract::Cervical cone biopsy has become an important surgical procedure for endocervical adenocarcinoma in situ (AIS), especially for patients who desire to retain their fertility. Establishing the usefulness of the endocervical margin status in cone biopsy specimens as a predictor of residual AIS is paramount. We examined th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.6.727

    authors: Goldstein NS,Mani A

    更新日期:1998-06-01 00:00:00

  • Reporting of Benign Endometrial Cells in Papanicolaou Tests.

    abstract:OBJECTIVES:The 2014 Bethesda System (TBS 2014) guidelines for reporting cervical cytology revised the age for reporting benign endometrial cells (BECs) from 40 years or older to age 45 years or older. We evaluated this change and further investigated if extending the reporting age to 50 years or older may be acceptable...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa041

    authors: Hernandez A,Schatz-Siemers N,Zhou F,Brandler TC,Negron R,Modi L,Elgert PA,Simsir A

    更新日期:2020-08-05 00:00:00

  • Cardiac troponin T is elevated in asymptomatic patients with chronic renal failure.

    abstract::Patients with chronic renal failure (CRF) are at increased risk for myocardial events that are difficult to evaluate due to atypical symptoms and chronically elevated protein markers of cardiac damage. This study evaluated cardiac troponin T (cTnT), a sensitive marker of cardiac injury, in patients with CRF without my...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.1.118

    authors: Frankel WL,Herold DA,Ziegler TW,Fitzgerald RL

    更新日期:1996-07-01 00:00:00

  • Fresh and citrated whole-blood specimens can produce different thromboelastography results in patients on extracorporeal membrane oxygenation.

    abstract:OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPYIQ9JNNSEN4Q

    authors: Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

    更新日期:2013-08-01 00:00:00

  • The usefulness of flow cytometric CD10 detection in the differential diagnosis of peripheral T-cell lymphomas.

    abstract::We studied the histologic and multiparameter flow cytometry (MFC) features of 12 cases of angioimmunoblastic T-cell lymphoma (AITL), 13 of mature T-cell lymphoma, and 25 control cases of reactive lymphoid hyperplasia to evaluate the role of CD10 in the differential diagnosis of peripheral T-cell lymphomas (PTCLs). A c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/MC7QRGPTV0LRR98X

    authors: Stacchini A,Demurtas A,Aliberti S,Francia di Celle P,Godio L,Palestro G,Novero D

    更新日期:2007-11-01 00:00:00

  • Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis.

    abstract::A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.3.381

    authors: Jennette JC,Lamanna RW,Burnette JP,Wilkman AS,Iskander SS

    更新日期:1982-09-01 00:00:00

  • Native-valve endocarditis caused by Staphylococcus epidermidis. A histologically confirmed case.

    abstract::Staphylococcus epidermidis is among the most common organisms isolated from blood cultures. Conversely, it is rarely a well-documented cause of natural-valve endocarditis. However, several authors have reported series of patients with the clinical picture of endocarditis and S. epidermidis bacteremia. Most of these ca...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.3.408

    authors: Littenberg B,Cooper B,Levitz R

    更新日期:1987-03-01 00:00:00

  • Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases.

    abstract::The purpose of our study was to clarify the prognosis of lymphoepithelioma-like carcinoma (LELC) of the lung, which is rare. We analyzed the clinicopathologic features of 32 cases of pulmonary LELC and compared the cases with 84 cases of pulmonary non-LELC with available long-term follow-up information. The results sh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/BUAN-BGFW-69U9-C3H8

    authors: Han AJ,Xiong M,Gu YY,Lin SX,Xiong M

    更新日期:2001-06-01 00:00:00

  • Ultrastructural examination of urinary sediment. Value in renal amyloidosis.

    abstract::Examination of urinary sediment has been recommended as a useful diagnostic aid for renal amyloidosis. This procedure was evaluated in the cases of 57 patients, including 11 with proven renal amyloidosis and 13 considered very likely to have the disease. At least three types of urinary fibrillar material were observed...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.1.36

    authors: Winer RL,Wuerker RB,Erickson JO,Cooper WL

    更新日期:1979-01-01 00:00:00

  • Adenovirus in the gastrointestinal tracts of immunosuppressed patients.

    abstract::Adenovirus was cultured from various gastrointestinal sites and one lung specimen from seven immunosuppressed patients, four of whom were bone marrow transplant recipients. Histologic examination and in situ hybridization studies of the lung demonstrated adenovirus in the bronchial epithelium and alveolar lining cells...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.4.555

    authors: Strickler JG,Singleton TP,Copenhaver CM,Erice A,Snover DC

    更新日期:1992-04-01 00:00:00

  • Mantle Cell Lymphoma With Mantle Zone Growth Pattern.

    abstract:OBJECTIVES:To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS:The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS:The patients with MCL-MZGP typically sought treatment at high clinical stages (...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz043

    authors: Yuan J,Li S,Liu X,Su RJ,Chen M,Wu X,Zheng G,Smith LM,Wang L,Li Y,Liu C,Zhou J,Shen Q,Zhang L,Wang E,Xu ML,Pan Z

    更新日期:2019-07-05 00:00:00

  • Characterization of two monoclonal antibodies in an immunohistochemical study of keratin 8 and 18 expression.

    abstract::Two monoclonal antibodies, UCD/AB 6.11 and UCD/PR 10.11, were evaluated for their patterns of immunohistochemical reactivity in a survey of paraffin-embedded human tissues by the avidin-biotin-immunoperoxidase technique. By two-dimensional immunoblotting, UCD/AB 6.11 reacts with keratin number 18 and UCD/PR 10.11 iden...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.4.472

    authors: Chan R,Edwards BF,Hu R,Rossitto PV,Min BH,Lund JK,Cardiff RD

    更新日期:1988-04-01 00:00:00

  • Impact of Use of Smaller Volume, Smaller Vacuum Blood Collection Tubes on Hemolysis in Emergency Department Blood Samples.

    abstract:Objectives:Hemolyzed blood samples commonly occur in hospital emergency departments (EDs). Our objective was to determine whether replacing standard large-volume/high-vacuum sample tubes with low-volume/low-vacuum tubes would significantly affect ED hemolysis. Methods:This was a prospective intervention of the use of ...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1093/ajcp/aqx082

    authors: Phelan MP,Reineks EZ,Berriochoa JP,Schold JD,Hustey FM,Chamberlin J,Kovach A

    更新日期:2017-10-01 00:00:00

  • Evaluation of the FIAX test for the detection of antibodies to herpes simplex virus and cytomegalovirus.

    abstract::Laboratory Branch Complement Fixation and FIAX (fluorescence immunoassay) were compared for the detection of antibodies to herpes simplex virus and cytomegalovirus in human sera. Of 68 sera with no antibodies to herpes simplex virus by complement fixation, one specimen was positive by FIAX (specificity, 98.6%). Of 75 ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.3.387

    authors: Segar JE,Smith TF,Ilstrup DM

    更新日期:1981-03-01 00:00:00

  • Hand-mirror cell leukemia. Report of nine cases and a review of the literature.

    abstract::In order to determine the significance of 40% or more leukemic cells in hand-mirror configuration in the bone marrow (hand-mirror cell leukemia), eight of 34 cases of acute lymphoblastic leukemia and one of 17 cases of acute myeloblastic leukemia were collected from a six-year period. Five of the eight patients who ha...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.5.651

    authors: Glassy EF,Sun NC,Okun DB

    更新日期:1980-11-01 00:00:00

  • Atypical glandular cells of undetermined significance. Diagnostic accuracy and interobserver variability using select cytologic criteria.

    abstract::Histologic follow-up of patients with the Bethesda system cervical-vaginal diagnosis of atypical glandular cells of undetermined significance (AGUS), "favor endocervical origin", or "not otherwise specified" (NOS) shows a high percentage of clinically significant (neoplastic or preneoplastic) lesions. Using the criter...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.3.299

    authors: Raab SS,Snider TE,Potts SA,McDaniel HL,Robinson RA,Nelson DL,Sigman JD,Thomas PA

    更新日期:1997-03-01 00:00:00

  • Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.

    abstract::The authors investigated the humoral and tissue expression of six antigens associated with medullary thyroid cancer (MTC): calcitonin (CT), calcitonin gene-related peptide (CGRP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), somatostatin (SRIF), and thyroglobulin (TG). The antigens were studied in th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.3.300

    authors: Pacini F,Basolo F,Elisei R,Fugazzola L,Cola A,Pinchera A

    更新日期:1991-03-01 00:00:00

  • Peroxidase activity in circulating mast cells in blast crisis of chronic granulocytic leukemia. Comparative studies with basophils and cutaneous mast cells.

    abstract::Although the hematopoietic origin of mast cells is very probable, the cell from which they originate is still a matter of speculation. The description of "transitional basophil/mast cells" in myeloproliferative disorders has suggested a common origin for basophils and mast cells. In a case of mast cell transformation ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.2.212

    authors: Gabriel LC,Escribano LM,Marie JP,Zittoun R,Navarro JL

    更新日期:1986-08-01 00:00:00

  • The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors.

    abstract::The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.3.286

    authors: Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

    更新日期:1998-03-01 00:00:00

  • Clinical and economic performance criteria for intraarterial and extraarterial blood gas monitors, with comparison with in vitro testing.

    abstract::The frequency with which blood gas measurements should be obtained is controversial because laboratory-based blood gas analyzers impose blood loss, delay, and cost on each measurement. Point-of-care analyzers eliminate the delay factor, but blood loss and cost factors remain. Optode microsensing can be adopted readily...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Shapiro BA

    更新日期:1995-10-01 00:00:00

  • Band neutrophil counts are unnecessary for the diagnosis of infection in patients with normal total leukocyte counts.

    abstract::The authors have assessed the clinical value of an "accurate" band count as a correlate to infection in 33 patients with a culture proven bacterial infection and a normal total leukocyte count. Thirty hematologically normal outpatients, presumably with no infections, were selected for the control group. Manual 500 cel...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.5.646

    authors: Ardron MJ,Westengard JC,Dutcher TF

    更新日期:1994-11-01 00:00:00

  • Male breast cancer.

    abstract::Breast cancer in men is a rare condition affecting only 1,000 men each year in the United States. Hormonal, genetic, and perhaps environmental factors appear to be important in development of the disease. Clinically, breast cancer in men resembles that seen in woman. Histologically the diseases are indistinguishable, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Hecht JR,Winchester DJ

    更新日期:1994-10-01 00:00:00

  • Evaluation of initial and deeper sections of esophageal biopsy specimens for detection of intestinal metaplasia.

    abstract::There are wide variations in the preparation of histologic sections from endoscopic esophageal biopsy specimens. We evaluated serial step sections from 261 esophageal or gastroesophageal junction biopsies at 4 levels to determine the first level at which goblet cell metaplasia (GCM) was detected. Deeper step sections ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/MGRX-LQG9-QVRV-VMCG

    authors: Chitkara YK,Eyre CL

    更新日期:2005-06-01 00:00:00

  • Profiles of black and Latin-American patients having pernicious anemia. HLA antigens, lymphocytotoxic antibody, anti-parietal cell antibody serum gastrin levels, and ABO blood groups.

    abstract::Because of the unusual presentation of pernicious anemia in many black women, a further characterization of this disease among the different racial groups was undertaken. The following were found. (1) Black women under the age of 50 years had a significantly lower prevalence of anti-parietal cell antibody than did "Eu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.3.291

    authors: Carmel R,Ozturk G,Johnson CS,Tung KS,Terasaki PI

    更新日期:1981-03-01 00:00:00

  • Flow cytometric measurement of antiplatelet antibodies.

    abstract::A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.4.518

    authors: Rosenfeld CS,Nichols G,Bodensteiner DC

    更新日期:1987-04-01 00:00:00

  • Low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion: a category with an increased outcome of high-grade lesions: use as a quality assurance measure.

    abstract::"Low-grade squamous intraepithelial lesion (LSIL), cannot exclude high-grade squamous intraepithelial lesion" (LSIL-H) is an increasingly used, equivocal interpretive category in gynecologic cytology. In an effort to evaluate its potential usefulness as a measure of quality assurance, we studied patterns of use of the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP8J4ROAVWOSHQ

    authors: Nishino HT,Wilbur DC,Tambouret RH

    更新日期:2012-08-01 00:00:00

  • Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis. A report of 27 cases.

    abstract::Kikuchi's lymphadenitis is a self-limiting condition typically affecting young patients. Surgical biopsy is unnecessary if a firm diagnosis can be rendered by fine-needle aspiration cytology (FNAC). The authors report the FNAC findings for 27 cases, including 24 female and 3 male patients aged 12 to 43 years. Histolog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.4.454

    authors: Tsang WY,Chan JK

    更新日期:1994-10-01 00:00:00