Abstract:
:In order to determine the significance of 40% or more leukemic cells in hand-mirror configuration in the bone marrow (hand-mirror cell leukemia), eight of 34 cases of acute lymphoblastic leukemia and one of 17 cases of acute myeloblastic leukemia were collected from a six-year period. Five of the eight patients who had acute lymphoblastic leukemia were children; the remaining patients were less than 40 years of age. Females outnumbered males two to one. Cytochemical and electron-microscopic studies were performed for three cases. The clinical presentations were similar to those of patients without the hand-mirror cell variant, except for a high incidence of central nervous system relapses (over 50% of patients) despite prophylaxis. When compared with patients with acute leukemia in equivalent age and morphologic categories, adults with the hand-mirror cell variant had a similar, but not better, prognosis, while children with the variant had a poorer prognosis. Additional studies must be performed to determine whether the hand-mirror cell variant warrants separation from other forms of acute leukemia.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Glassy EF,Sun NC,Okun DBdoi
10.1093/ajcp/74.5.651subject
Has Abstractpub_date
1980-11-01 00:00:00pages
651-6issue
5eissn
0002-9173issn
1943-7722journal_volume
74pub_type
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journal_title:American journal of clinical pathology
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更新日期:1984-01-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/FC4H-LM5V-VCW8-DNJU
更新日期:2000-02-01 00:00:00
abstract:Objectives:According to current guidelines, either immunohistochemistry (IHC) or in situ hybridization (ISH) can be used to determine human epidermal growth factor receptor 2 (Her2/neu) status in breast carcinoma. While the guidelines explicitly delineate result interpretation, there is no consensus on the most appropr...
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1989-02-01 00:00:00
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更新日期:1990-01-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2008-07-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1976-01-01 00:00:00
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更新日期:2015-06-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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