Abstract:
:Histologic follow-up of patients with the Bethesda system cervical-vaginal diagnosis of atypical glandular cells of undetermined significance (AGUS), "favor endocervical origin", or "not otherwise specified" (NOS) shows a high percentage of clinically significant (neoplastic or preneoplastic) lesions. Using the criteria of atypical single cells, irregular nuclear membranes, and decreased cytoplasm, eight observers retrospectively reclassified 88 AGUS, "favor endocervical", or NOS smears using a probabilistic scheme. Follow-up showed 46 clinically significant and 42 benign lesions. The mean accuracy for all observers and the experienced observers was 65% and 72%, respectively. For the experienced observers, the mean specificity of a "favor clinically significant" category was 72%; the mean sensitivity of a "favor benign" category was 90%. For the less experienced observers, subclassification had poor predictive value. We conclude that experienced observers may use specific criteria to correctly subclassify AGUS lesions, and this may aid in patient management.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Raab SS,Snider TE,Potts SA,McDaniel HL,Robinson RA,Nelson DL,Sigman JD,Thomas PAdoi
10.1093/ajcp/107.3.299subject
Has Abstractpub_date
1997-03-01 00:00:00pages
299-307issue
3eissn
0002-9173issn
1943-7722journal_volume
107pub_type
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journal_title:American journal of clinical pathology
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更新日期:1997-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1997-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1990-02-01 00:00:00
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