Abstract:
:We studied the magnitude, significance, and origin of an analytic bias that emerged between our point-of-care (POC) and our central laboratory (CL) methods for the measurement of hemoglobin A1c (HbA1c) and evaluated the analytic accuracy of 7 commonly used HbA1c methods relative to the National Glycohemoglobin Standardization Program (NGSP) reference method. The POC and CL methods were compared by split-sample analysis of clinical specimens and time series analyses of the HbA1c results reported for a 33-month period. The relative accuracies of 7 HbA1c methods were evaluated using College of American Pathologists proficiency survey results. Long-term drifts in the CL- and POC-analyzed test results caused the median intermethod bias [(POC result)-(CL result)] to increase from -0.4% to -0.9% HbA1c. Systematic biases, drifts in analytic performance over time, and intermethod variability were frequently observed among the 7 NGSP-certified HbA1c methods. Intermethod variability is a potential source of inaccuracy whenever HbA1c results are interpreted relative to universal, fixed, clinical decision thresholds.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Holmes EW,Erşahin C,Augustine GJ,Charnogursky GA,Gryzbac M,Murrell JV,McKenna KM,Nabhan F,Kahn SEdoi
10.1309/U3GPPTCBP1VLL8AWsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
540-7issue
4eissn
0002-9173issn
1943-7722pii
U07173424X4313L2journal_volume
129pub_type
杂志文章abstract::We report serum enzyme patterns in three patients with polymyositis or dermatomyositis whose cases posed potential problems in distinguishing malignancy, hepatocellular damage, and myocardial infarction from myositis. The alanine aminotransferase showed five- to 16-fold elevations. The creatine kinase MB isoenzyme and...
journal_title:American journal of clinical pathology
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更新日期:1980-04-01 00:00:00
abstract::Campylobacter fetus subspecies jejuni has recently been recognized as a significant cause of enteritis in humans. The organism has been previously postulated to cause illness by direct invasion of the mucosa of the gastrointestinal tract, but this has not been documented. Reported is a case of Campylobacter enteritis ...
journal_title:American journal of clinical pathology
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更新日期:1980-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1999-11-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1984-03-01 00:00:00
abstract:Objectives:Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00
abstract::The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...
journal_title:American journal of clinical pathology
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更新日期:1983-11-01 00:00:00
abstract::The clinical and pathologic features of 64 inflammatory fibroid polyps of the large and small bowel in 63 patients are reported. Six of the lesions in the small bowel were studied by electron microscopy. Follow-up information was obtained from 39 patients. The lesion was always benign, occurred at all ages, and had a ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/64.3.410
更新日期:1975-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1977-07-01 00:00:00
abstract:OBJECTIVES:We report a case of a patient with diabetes mellitus and unexpectedly low hemoglobin A1c results associated with paroxysmal nocturnal hemoglobinuria (PNH). We review the impact of shortened RBC half-life on the interpretation of hemoglobin A1c levels. METHODS:Patient history and laboratory test results were...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/71.5.595
更新日期:1979-05-01 00:00:00
abstract::A tumor of the larynx composed of a small infiltrating and well-differentiated squamous cell carcinoma and a large polypoid sarcomatous mass showing the histologic features of the malignant giant cell tumor of soft parts (MGCT) is reported. Other types of sarcomatous components have been described with squamous cell c...
journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/82.3.340
更新日期:1984-09-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1989-10-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/89.4.488
更新日期:1988-04-01 00:00:00
abstract::Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/7Y7N-M1WM-R0YK-M2VA
更新日期:2002-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1977-02-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1990-04-01 00:00:00
abstract::Anti-sperm antibodies from serum and seminal plasma were detected by concurrent flow cytometry and epifluorescence microscopy using fluorescein-conjugated antihuman immunoglobulins. Experimental conditions were designed, taking advantage of several monoclonal antisperm antibodies, to test aspects of the assay before c...
journal_title:American journal of clinical pathology
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更新日期:1991-02-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2010-09-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/84.3.391
更新日期:1985-09-01 00:00:00
abstract::To compare the Affirm VPIII molecular test (Becton Dickinson, Burlington, NC) with morphologic identification used in routine Papanicolaou (Pap) test screening in the detection and identification of Candida species, Trichomonas vaginalis, and Gardnerella vaginalis, we identified 431 cases with a concomitant Pap test a...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
abstract::Chicken pox, although common, is rarely associated with autoimmune hemolytic anemia. Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox. The cold agglutinin appeared to be a polyclonal immunoglobulin M antibody wit...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/97.1.92
更新日期:1992-01-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/4D1A04NCDK96WFY7
更新日期:2007-03-01 00:00:00
abstract::Thirty-five patients with dermatopathic lymphadenopathy, 12 with (9 patients and 3 follow-up) and 23 without associated mycosis fungoides, and 7 controls with 26 lymph nodes were studied by light microscopic examination and immunostaining for S-100 protein. Fourteen of these cases were examined ultrastructurally. The ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/87.2.187
更新日期:1987-02-01 00:00:00
abstract::Chemotherapy is a well-established therapeutic approach for several malignancies, but its clinical efficacy is often limited by its related cardiotoxicity, which leads to cardiomyopathy, possibly evolving into heart failure. To detect cardiac damage, the adopted diagnostic approach is the estimation of left ventricula...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
abstract::Intrauterine clostridial infections have historically been associated with puerperal sepsis, often subsequent to instrumented abortions. Isolated reports have been associated with a malignant neoplasm or degenerating leiomyoma, most often after instrumentation, radiation therapy, or chemotherapy. In these cases, well-...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/91.1.104
更新日期:1989-01-01 00:00:00
abstract::Two cases of giant-cell arteritis of uterus were found incidentally in association with uterine prolapse. One similar case has been reported in the literature. Microscopic examination disclosed fragmentation of the elastic laminae of the myometrial arteries with a giant-cell and mononuclear infiltrate. The relationshi...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/65.3.308
更新日期:1976-03-01 00:00:00