Immune hemolytic anemia associated with probenecid.

Abstract:

:Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the patient's RBCs, with and without the presence of drug, were nonreactive. Upon the discontinuation of probenecid, the patient's hemoglobin level improved steadily. We believe this to be the first reported case of immune hemolytic anemia associated with probenecid.

journal_name

Am J Clin Pathol

authors

Sosler SD,Behzad O,Garratty G,Lee CL,Postoway N,Khomo O

doi

10.1093/ajcp/84.3.391

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

391-4

issue

3

eissn

0002-9173

issn

1943-7722

journal_volume

84

pub_type

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