Reference range determination for whole-blood platelet aggregation using the Multiplate analyzer.

abstract：:We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Pri...

journal_title：American journal of clinical pathology

authors： Ren R,Guo M,Sneige N,Moran CA,Gong Y

更新日期：2006-09-01 00:00:00

abstract：:A patient who had masses in the breasts clinically suggestive of neoplasia had fibrous mastopathy and striking deposition of ochronotic pigment within the soft tissue of the breast. The gross appearance and light microscopic features are illustrated. The histochemical features of ochronotic pigment and the difficulty ...

journal_title：American journal of clinical pathology

authors： Lefer LG,Rosier RP

更新日期：1979-03-01 00:00:00

abstract：:Patients with chronic renal failure (CRF) are at increased risk for myocardial events that are difficult to evaluate due to atypical symptoms and chronically elevated protein markers of cardiac damage. This study evaluated cardiac troponin T (cTnT), a sensitive marker of cardiac injury, in patients with CRF without my...

journal_title：American journal of clinical pathology

authors： Frankel WL,Herold DA,Ziegler TW,Fitzgerald RL

更新日期：1996-07-01 00:00:00

abstract：:Evaluation of blood cells to determine immunologic status is becoming an important clinical application of flow cytometric analysis. For a wider use of immunophenotyping technology in clinical laboratories, the authors developed a rapid method to detect monoclonal antibody-labeled cells using forward light scatter/abs...

journal_title：American journal of clinical pathology

authors： Kim YR,Paseltiner L,Kling G,Yeh CK

更新日期：1992-03-01 00:00:00

abstract：:Two commercial enzyme-linked immunosorbent assays (ELISA) for detection of herpes simplex virus (HSV) antigen in direct clinical specimens were compared with cell culture in primary rabbit kidney and MRC-5. With a total of 238 specimens, the sensitivity and specificity of the Dako ELISA method were determined to be 70...

journal_title：American journal of clinical pathology

authors： Warford AL,Levy RA,Strong CA,Rekrut KA

更新日期：1986-02-01 00:00:00

abstract：:Anemia developing during the course of chronic renal disease is a frequent complication often necessitating periodic transfusion therapy. A number of etiologic factors have been implicated, including decreased production of erythropoietin; decreased erythrocyte life span secondary to uremia and splenomegaly; increased...

journal_title：American journal of clinical pathology

authors： Hancock DE,Onstad JW,Wolf PL

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...

journal_title：American journal of clinical pathology

authors： Seo AN,Park HJ,Lee HS,Park JO,Chang HE,Nam KH,Choe G,Park KU

更新日期：2014-09-01 00:00:00

abstract：:Centerin (SERPINA9/GCET1) is a protease inhibitor with expression restricted to germinal center B cells and lymphoid malignancies with germinal center B-cell maturation. Expression of the centerin gene transcript, along with bcl-6 and GCET2/HGAL, constitutes a molecular signature associated with a good prognosis in di...

journal_title：American journal of clinical pathology

authors： Paterson MA,Hosking PS,Coughlin PB

更新日期：2008-07-01 00:00:00

abstract：:A simple assay based on molecular light scattering was developed to detect soluble immune complexes. In this assay the percentage of relative light scattering (%RLS) caused by complexes in buffer containing polyethylene glycol 6000 (PEG) was measured with a laser nephelometer. In low concentrations of PEG (3%-5%), IgG...

journal_title：American journal of clinical pathology

authors： Koethe SM,Melton HE,Jendrzejczak Z

更新日期：1980-12-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT...

journal_title：American journal of clinical pathology

authors： Rausei-Mills V,Chang KL,Gaal KK,Weiss LM,Huang Q

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:Cytogenetics defines disease entities and predicts prognosis in acute myeloid leukemia (AML). Conventional karyotyping provides a comprehensive view of the genome, while fluorescence in situ hybridization (FISH) detects targeted abnormalities. The aim of this study was to compare the utility of karyotyping a...

journal_title：American journal of clinical pathology

authors： He R,Wiktor AE,Hanson CA,Ketterling RP,Kurtin PJ,Van Dyke DL,Litzow MR,Howard MT,Reichard KK

更新日期：2015-06-01 00:00:00

abstract：:The diagnostic expert system for colonic lesions (DESCL) was designed to discriminate colonic adenoma and adenocarcinoma from normal colonic tissue. Although it was originally developed for use in conjunction with a machine vision analytic system, the DESCL has evolved into a teaching tool and a model for conceptual m...

journal_title：American journal of clinical pathology

authors： Graham AR,Paplanus SH,Bartels PH

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

journal_title：American journal of clinical pathology

authors： Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:Universal screening of upper tract urothelial carcinoma (UTUC) for Lynch syndrome by mismatch repair (MMR) protein immunohistochemistry (IHC) has been recommended by some investigators. Herein, we assess this recommendation retrospectively by simulating its performance on a retrospective, unselected cohort o...

journal_title：American journal of clinical pathology

authors： Gayhart MG,Johnson N,Paul A,Quillin JM,Hampton LJ,Idowu MO,Smith SC

更新日期：2020-11-04 00:00:00

abstract：:We investigated the pathologic significance of ductular reactions in chronic liver diseases with respect to cellular senescence. The expression of senescence-associated markers (p16(INK4a) and p21(WAF1/Cip1)), cell proliferation, cell cycle markers (cyclin D and cyclin A), and neural cell adhesion molecule (NCAM) was ...

journal_title：American journal of clinical pathology

authors： Sasaki M,Ikeda H,Yamaguchi J,Miyakoshi M,Sato Y,Nakanuma Y

更新日期：2010-02-01 00:00:00

abstract：:A very simple method of computer-assisted reporting of surgical pathology (including gross description, microscopic description, and diagnosis) has been developed. This method is based on a modification of the existing microbiology program and files in the comprehensive MedLab Company Pathlab computer system, with the...

journal_title：American journal of clinical pathology

authors： Davey PW,Vaughan KD

更新日期：1982-09-01 00:00:00

abstract：:HMB45 is a melanoma-specific monoclonal antibody that has found widespread use in diagnostic pathology. Recent reports, however, have suggested that this antibody may cross-react with a small number of carcinomas and other epithelial cells. The authors tested the hypothesis that these latter reports represent examples...

journal_title：American journal of clinical pathology

authors： Bonetti F,Pea M,Martignoni G,Mombello A,Colombari R,Zamboni G,Scarpa A,Piubello Q,Bacchi CE,Gown AM

更新日期：1991-04-01 00:00:00

abstract：:Urine myoglobin concentrations are measured clinically to assess rhabdomyolysis and the related risk of renal damage. We studied urine myoglobin concentrations in vitro to explore the factors affecting stability. Myoglobin was very unstable in urine specimens, especially below pH 6.5, and its immunoreactivity deterior...

journal_title：American journal of clinical pathology

authors： Chen-Levy Z,Wener MH,Toivola B,Daum P,Reyes M,Fine JS

更新日期：2005-03-01 00:00:00

abstract：:The development of chemoresistance in a variety of cancers seems related to overexpression of the P-glycoprotein (P-gp) drug pump. Nephroblastoma, the most common malignant renal tumor of childhood, usually is responsive to treatment, and prognosis is favorable in most cases. However, the disease in a subset of patien...

journal_title：American journal of clinical pathology

authors： Camassei FD,Arancia G,Cianfriglia M,Bosman C,Francalanci P,Ravà L,Jenkner A,Donfrancesco A,Boldrini R

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:Ancillary molecular testing on tissue is available for mycobacterial disease; however, judicious use of highly sensitive tests, such as polymerase chain reaction (PCR) and sequencing, should be guided by histologic parameters. We sought to investigate the utility of performing acid-fast stains (AFS) on skin ...

journal_title：American journal of clinical pathology

authors： Laga AC,Milner DA Jr,Granter SR

更新日期：2014-04-01 00:00:00

abstract：:Lesions of the breast containing extravasated mucin span a continuum from benign mucoceles to invasive mucinous (colloid) carcinoma. It is well known that distinguishing benign from malignant mucinous lesions is difficult infine-needle aspiration material. Whether these lesions also are difficult to distinguish in cor...

journal_title：American journal of clinical pathology

authors： Renshaw AA

更新日期：2002-07-01 00:00:00

abstract：:Carumonam, a new monobactam, was found to have an anti-microbial spectrum similar to aztreonam. Its spectrum includes Enterobacteriaceae, Haemophilus influenzae, pathogenic Neisseria species, Pseudomonas aeruginosa, and some streptococci. Staphylococcus species, enterococci, and many other nonenteric gram-negative bac...

journal_title：American journal of clinical pathology

authors： Jones RN,Barry AL,Thornsberry C,Fuchs PC,Packer RR

更新日期：1986-11-01 00:00:00

abstract：:The Sysmex R-3000 (TOA Medical Electronics, Kobe, Japan) evaluates maturation of reticulocytes by quantitating the fraction of reticulocytes within low-, middle-, and high-fluorescence intensity regions. We defined the immature reticulocyte fraction (IRF) as the sum of the fraction of high-fluorescence intensity regio...

journal_title：American journal of clinical pathology

authors： Chang CC,Kass L

更新日期：1997-07-01 00:00:00

abstract：:We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). Specimens were analyzed for claudin-1 and claudin-3 expression using immunohistochemical...

journal_title：American journal of clinical pathology

authors： Kleinberg L,Holth A,Fridman E,Schwartz I,Shih IeM,Davidson B

更新日期：2007-06-01 00:00:00

abstract：:This study aimed to ascertain pathologic findings of surgical follow-up excision (FUE) on patients who had radiologic finding of calcifications and lobular neoplasia (LN) on core biopsy. Breast core biopsy specimens from 2006-2011 with a diagnosis of pure classic-type LN (lobular carcinoma in situ [LCIS] and atypical ...

journal_title：American journal of clinical pathology

authors： Zhao C,Desouki MM,Florea A,Mohammed K,Li X,Dabbs D

更新日期：2012-07-01 00:00:00

abstract：Objectives:Free light chain (FLC) measurement gained a lot of interest for diagnostic workup of monoclonal gammopathy. Methods:We evaluated the performance of turbidimetric polyclonal Freelite (The Binding Site, Birmingham, UK) assays on Cobas 6000 (Roche Diagnostics, Rotkreuz, Switzerland) and nephelometric monoclona...

journal_title：American journal of clinical pathology

authors： Messiaen AS,De Sloovere MMW,Claus PE,Vercammen M,Van Hoovels L,Heylen O,Debrabandere J,Vanpoucke H,De Smet D

更新日期：2017-06-01 00:00:00

abstract：:Tissue repositories maintained by pathology departments represent an abundant resource of clinically annotated human specimens. The storage expenses associated with pathology archives are known to administrators of most pathology departments. However, such basic repository characteristics as the quality of stored mate...

journal_title：American journal of clinical pathology

authors： Smith MA,Barnes EL,Chiosea SI

更新日期：2011-05-01 00:00:00

abstract：:Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...

journal_title：American journal of clinical pathology

authors： Heinz T,Pezzlo M,Thrupp L

更新日期：1982-03-01 00:00:00

abstract：:The cases of 20 patients, each of whom has a positive lupus erythematosus cell preparation and a negative antinuclear factor test, are presented. The concept of a false-positive lupus erythematosus preparation is suggested. Five common mechanisms causing a false-negative antinuclear factor test are discussed and evalu...

journal_title：American journal of clinical pathology

authors： Koller SR,Johnston CL Jr,Moncure CW

更新日期：1976-09-01 00:00:00

abstract：OBJECTIVES:To compare next-generation sequencing (NGS) platforms with mutation-specific analysis platforms in a clinical setting, in terms of sensitivity, mutation specificity, costs, capacity, and ease of use. METHODS:We analyzed 25 formalin-fixed, paraffin-embedded lung cancer samples of different size and tumor per...

journal_title：American journal of clinical pathology

authors： Hinrichs JW,van Blokland WT,Moons MJ,Radersma RD,Radersma-van Loon JH,de Voijs CM,Rappel SB,Koudijs MJ,Besselink NJ,Willems SM,de Weger RA

更新日期：2015-04-01 00:00:00