Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification.

Abstract:

:This study aimed to ascertain pathologic findings of surgical follow-up excision (FUE) on patients who had radiologic finding of calcifications and lobular neoplasia (LN) on core biopsy. Breast core biopsy specimens from 2006-2011 with a diagnosis of pure classic-type LN (lobular carcinoma in situ [LCIS] and atypical lobular hyperplasia [ALH]) with no history of invasive carcinoma (IC) or ductal carcinoma in situ (DCIS) were studied. Two hundred thirty-seven patients with the diagnosis of calcium on radiologic studies had FUE and were included in the study. Cases were divided into group 1 (pure ALH, n = 163) and group 2 (pure LCIS, n = 74). The interval between the core biopsy and FUE ranged from 0.2 to 7 months (mean, 1.5 ± 1.1 months). The risk of upstaging on FUE (DCIS or IC) is as follows: LCIS, 8.1% (6/74) and ALH, 3.1% (5/163). The data indicate that there is a low risk of upstaging to DCIS/IC from a core biopsy diagnosis of lobular neoplasia.

journal_name

Am J Clin Pathol

authors

Zhao C,Desouki MM,Florea A,Mohammed K,Li X,Dabbs D

doi

10.1309/AJCPYG48TUTFIBMR

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

72-8

issue

1

eissn

0002-9173

issn

1943-7722

pii

138/1/72

journal_volume

138

pub_type

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