TCL1 expression and Epstein-Barr virus status in pediatric Burkitt lymphoma.

Abstract:

:Elevated T-cell leukemia-1 (TCL1) oncoprotein expression might promote human Burkitt lymphoma (BL) because increased TCL1 causes Burkitt-like lymphomas in TCL1 transgenic mice. Epstein-Barr virus (EBV) infection has been implicated as a cause of increased TCL1 expression in multiple BL cell lines, suggesting a critical connection between EBV and TCL1-induced BL. The TCL1 expression and EBV status of 14 sporadic pediatric BL cases was determined by immunohistochemical staining for TCL1 and in situ hybridization for EBV-encoded RNA (EBER). Our results showed TCL1 protein in 11 cases, predominantly in the nucleus with strong-intensity staining. EBER was positive in 4 cases, with 3 of these cases also TCL1+. In the 10 cases that were EBER-, TCL1 was strongly positive in 8. These data indicate that the TCL1 oncoprotein is expressed strongly in most pediatric BL cases. However, persistent EBV is not essential for increased TCL1 expression, although elevated TCL1 and c-MYC coexpression might cooperate in the development of most pediatric and adult BL cases.

journal_name

Am J Clin Pathol

authors

Teitell MA,Lones MA,Perkins SL,Sanger WG,Cairo MS,Said JW

doi

10.1309/77V7U4E03V69QHRR

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

569-75

issue

4

eissn

0002-9173

issn

1943-7722

pii

77V7U4E03V69QHRR

journal_volume

124

pub_type

杂志文章
  • Clinical trial of a new disposable bleeding-time device.

    abstract::A new disposable bleeding time device (Hemalet) was tested in 20 normal individuals and 11 patients with various bleeding disorders. The results were compared with those of Simplate II. The mean bleeding time for normal individuals was 5.4 +/- 1.5 (mean +/- 1 SD) minutes by Hemalet and 5.8 +/- 1.4 (mean +/- 1 SD) minu...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1093/ajcp/85.5.610

    authors: Toomey KC,Kim HC,Kosmin M,Saidi P

    更新日期:1986-05-01 00:00:00

  • Evaluation of initial and deeper sections of esophageal biopsy specimens for detection of intestinal metaplasia.

    abstract::There are wide variations in the preparation of histologic sections from endoscopic esophageal biopsy specimens. We evaluated serial step sections from 261 esophageal or gastroesophageal junction biopsies at 4 levels to determine the first level at which goblet cell metaplasia (GCM) was detected. Deeper step sections ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/MGRX-LQG9-QVRV-VMCG

    authors: Chitkara YK,Eyre CL

    更新日期:2005-06-01 00:00:00

  • Restricted kappa/lambda light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditis.

    abstract::To determine the diagnostic significance of the kappa/lambda ratio in germinal center (GC) B cells in Hashimoto thyroiditis (HT), we used 4-color flow cytometry to immunophenotype 27 samples (21 patients) of well-characterized HT B-cell clonality was analyzed further by polymerase chain reaction (PCR) of the immunoglo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Chen HI,Akpolat I,Mody DR,Lopez-Terrada D,De Leon AP,Luo Y,Jorgensen J,Schwartz MR,Chang CC

    更新日期:2006-01-01 00:00:00

  • A side-by-side evaluation of four platelet-counting instruments.

    abstract::The performances of four instruments for counting platelets were evaluated in a side-by-side study: the Haema-Count MK-4/HC, an electronic impedance instrument that counts platelets in platelet-rich plasma; the Ultra-Flo 100, and the Coulter Counter Model S-Plus, electronic impedance instruments that count platelets i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.2.119

    authors: Dalton WT Jr,Bollinger P,Drewinko B

    更新日期:1980-08-01 00:00:00

  • Pathologic findings from the national surgical adjuvant breast project (protocol no. 4). II. The significance of regional node histology other than sinus histiocytosis in invasive mammary cancer.

    abstract::The morphologic appearances of regional lymph nodes in radical mastectomy specimens obtained from 303 women entered into a prospective study of invasive breast cancer were categorized into patterns that have been considered to reflect immunologic function. An attempt was made to correlate these with 31 other histologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.1.21

    authors: Fisher ER,Gregorio R,Redmond C,Dekker A,Fisher B

    更新日期:1976-01-01 00:00:00

  • Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences:  A Model for Pathology Services in Sub-Saharan Africa.

    abstract:OBJECTIVES:The incidence of lymphoproliferative disorders (LPDs) is increasing in sub-Saharan Africa (SSA) due to population growth, aging, and human immunodeficiency virus (HIV). Despite significant burden, resources for diagnosis and treatment of LPDs are limited, with little infrastructure to deliver modern patholog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw118

    authors: Montgomery ND,Liomba NG,Kampani C,Krysiak R,Stanley CC,Tomoka T,Kamiza S,Dhungel BM,Gopal S,Fedoriw Y

    更新日期:2016-10-01 00:00:00

  • pH, PCO2 and PO2 in "high-volume" platelet concentrates prepared by discontinuous-flow centrifugation and stored in polyvinylchloride and plyethylene containers.

    abstract::High-volume (200 ml) platelet concentrates prepared by discontinuous-flow centrifugation, with counts as high as ca. 2.0 x 10(12)/l, were stored in either 600 ml-capacity polyvinylchloride bags or 800-ml capacity polyethylene bags. Both polyvinylchloride and polyethylene bags appeared adequate for 24-hour storage of p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.397

    authors: Rosenstein R,Lawe JE,North JG

    更新日期:1980-03-01 00:00:00

  • High-density lipoprotein cholesterol. Significant bias between methods.

    abstract::Cholesterol content of the high-density lipoproteins has become of interest in evaluating the risk of development of coronary heart disease. There is an inverse relationship between high-density lipoprotein cholesterol and risk. The authors found a significant bias (11.1 mg/dl; 0.289 mmol/l) in a comparison of a rapid...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.5.564

    authors: Gerson B,Dean L,Copeland BE

    更新日期:1979-05-01 00:00:00

  • Analytic inaccuracy resulting from hematology specimen characteristics. Three cases of clinically misleading artifacts affecting white blood cell and platelet counts.

    abstract::Sporadically, hematology analyzers generate grossly erroneous results for one or several parameters of the complete blood count (CBC) because of a characteristic or peculiarity of an individual patient specimen. This article presents three cases of relatively less well-known analytic errors of this sort, falsely eleva...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.3.295

    authors: Savage RA

    更新日期:1989-09-01 00:00:00

  • Comparison of the Diagnostic Value Between Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Histopathologic Examination in Sentinel Lymph Nodes for Patients With Gastric Carcinoma.

    abstract:OBJECTIVES:Sentinel lymph node (SLN)-based diagnosis in gastric cancers has shown varied sensitivities and false-negative rates in several studies. Application of the reverse transcription-polymerase chain reaction (RT-PCR) in SLN diagnosis has recently been proposed. METHODS:A total of 155 SLNs from 65 patients with ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw055

    authors: Kwak Y,Nam SK,Shin E,Ahn SH,Lee HE,Park do J,Kim WH,Kim HH,Lee HS

    更新日期:2016-05-01 00:00:00

  • A computer system for cytology in a private laboratory using a PDP 8/E minicomputer.

    abstract::A computer software package written in Dibol for a PDP 8/E computer is described that is designed for the needs of the cytology department of a moderate-sized private medical laboratory. Computerized accessioning of cases, report preparation and printing, historical filing, activity summary reports, and direct patient...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.4.421

    authors: Ashworth CT,McConnell TH,Ashworth RD,Nielsen CR,Sanford J

    更新日期:1979-04-01 00:00:00

  • The use of fine needle aspiration cytology for the distinction of pancreatic mucinous neoplasia.

    abstract::Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/Y16QCXE3YGMXX19Q

    authors: Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

    更新日期:2008-01-01 00:00:00

  • Audit of Use and Overuse of Serum Protein Immunofixation Electrophoresis and Serum Free Light Chain Assay in Tertiary Health Care: A Case for Algorithmic Testing to Optimize Laboratory Utilization.

    abstract:OBJECTIVES:Overuse of laboratory tests is a persistent issue. We examined the use and overuse of serum immunofixation electrophoresis and serum free light chain assays to develop an algorithm for optimizing utilization. METHODS:A retrospective review of all tests, for investigation of monoclonal gammopathies, for all ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw026

    authors: Heaton C,Vyas SG,Singh G

    更新日期:2016-04-01 00:00:00

  • Micromorphometric features of positive sentinel lymph nodes predict involvement of nonsentinel nodes in patients with melanoma.

    abstract::The aim of the present study was to determine whether micromorphometric features of positive sentinel lymph nodes (SLNs) from patients with melanoma are useful for predicting further nodal involvement in completion lymph node dissection (CLND) specimens. Of 986 patients with melanoma undergoing SLN biopsy between Marc...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/TDWJ-TR15-TDM1-TG7Q

    authors: Scolyer RA,Li LX,McCarthy SW,Shaw HM,Stretch JR,Sharma R,Thompson JF

    更新日期:2004-10-01 00:00:00

  • Transfusion-related acute lung injury: a case-control pilot study of risk factors.

    abstract::Transfusion-related acute lung injury (TRALI) is the leading cause of mortality from transfusion therapy. Recipient, donor, and blood product risk factors may have important roles in the occurrence of TRALI. A case-control pilot study of 6 TRALI cases in which HLA-antibody concordance was found and 20 control subjects...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HC4PVY24NJXMQ884

    authors: Sanchez R,Bacchetti P,Toy P

    更新日期:2007-07-01 00:00:00

  • Elevation of myeloperoxidase in conjunction with cardiac-specific markers after marathon running.

    abstract::Cardiac-related death has been reported following strenuous exercise, and biochemical markers predicting adverse outcomes would be useful. Despite the fact the myeloperoxidase (MPO) release may precede myocardial injury and identify at-risk patients earlier than traditional markers, information on the effects of marat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/1D62H6KRFTVQRJ0A

    authors: Melanson SE,Green SM,Wood MJ,Neilan TG,Lewandrowski EL

    更新日期:2006-12-01 00:00:00

  • Clinical Significance of Isolated Myeloperoxidase Expression in Pediatric B-Lymphoblastic Leukemia.

    abstract:Objectives:Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence of B-lineage and absence of specific myeloid or T-lineage markers. Rare cases of otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an absence of other myeloid markers, but the cli...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqx021

    authors: Oberley MJ,Li S,Orgel E,Phei Wee C,Hagiya A,O'Gorman MRG

    更新日期:2017-04-01 00:00:00

  • Essential thrombocythemia with acquired von Willebrand's disease.

    abstract::Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.102

    authors: Raman BK,Sawdyk M,Saeed SM

    更新日期:1987-07-01 00:00:00

  • Interleukin-2 and interferon-gamma production in follicular lymphomas.

    abstract::In situ hybridization with specific RNA radiolabeled probes was used to analyze the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by 21 low-grade follicular lymphomas (FLs). All of the 21 FLs tested contained lymphokine-synthesizing cells in the interfollicular and follicular areas. Enumeration o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.1.55

    authors: Peuchmaur M,Emilie D,Crevon MC,Brousse N,Gaulard P,D'Agay MF,Galanaud P,Solal-Celigny P

    更新日期:1991-01-01 00:00:00

  • Mean platelet volume during coagulase-negative staphylococcal sepsis in neonates.

    abstract::Coagulase-negative staphylococci are the most common cause of late-onset septicemia in neonates in intensive care nurseries. Clinical and laboratory diagnosis of infection with coagulase-negative staphylococci can be difficult. The authors reviewed serial mean platelet volumes of 18 infants in whom coagulase-negative ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.1.69

    authors: O'Connor TA,Ringer KM,Gaddis ML

    更新日期:1993-01-01 00:00:00

  • Sporadic Fundic Gland Polyps With Low-Grade Dysplasia: A Large Case Series Evaluating Pathologic and Immunohistochemical Findings and Clinical Behavior.

    abstract:OBJECTIVES:Fundic gland polyps (FGPs) occur in two clinical settings, sporadic and syndromic. Epithelial dysplasia is rare in sporadic FGPs, and progression data from large series are lacking. The aim of this study was to evaluate the clinical, morphologic, and immunohistochemical features in a large series of sporadic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPGK8QTYPUQJYL

    authors: Levy MD,Bhattacharya B

    更新日期:2015-10-01 00:00:00

  • The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening.

    abstract::Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement of RBC subpopulations is now available on the Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe the new formulas: % microcytic - % hypochromic; and % microcytic - % hypochromic - red cell distributio...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPJRH1I0XTNFGA

    authors: Urrechaga E,Borque L,Escanero JF

    更新日期:2011-03-01 00:00:00

  • Computer-assisted diagnostic surgical pathology reporting.

    abstract::A very simple method of computer-assisted reporting of surgical pathology (including gross description, microscopic description, and diagnosis) has been developed. This method is based on a modification of the existing microbiology program and files in the comprehensive MedLab Company Pathlab computer system, with the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.3.337

    authors: Davey PW,Vaughan KD

    更新日期:1982-09-01 00:00:00

  • Oxidized-LDL/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes.

    abstract::Oxidized low-density lipoprotein (oxLDL)/beta(2)-glycoprotein I (beta2GPI) complexes have been implicated in atherogenesis. oxLDL/beta2GPI complexes were measured in 339 patients with suspected acute coronary syndromes. Approximately 68% had angiographically documented coronary artery disease (CAD) and significantly h...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP88WVRDRDFBAS

    authors: Greco TP,Conti-Kelly AM,Anthony JR,Greco T Jr,Doyle R,Boisen M,Kojima K,Matsuura E,Lopez LR

    更新日期:2010-05-01 00:00:00

  • Sensitivity and specificity of antibodies on necrotic tumor tissue.

    abstract::Immunohistochemistry occasionally is used to determine the lineage of entirely necrotic tumors. However, the sensitivity and specificity of antibodies on necrotic tissue are unknown. To determine the usefulness of immunohistochemistry with necrotic lesions, a series of 24 known tumors consisting of 14 carcinomas, 2 ly...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.5.641

    authors: Judkins AR,Montone KT,LiVolsi VA,van de Rijn M

    更新日期:1998-11-01 00:00:00

  • Fibromatosis of the Breast: Diagnostic Accuracy of Core Needle Biopsy.

    abstract:Objectives:Fibromatosis of the breast is an uncommon neoplasm with potential for local recurrence. Treatment has traditionally been surgical excision with current trends toward conservative management. Given the option of observation after diagnosis by core needle biopsy (CNB), we sought to evaluate the accuracy of CNB...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqx065

    authors: Kuba MG,Lester SC,Giess CS,Bertagnolli MM,Wieczorek TJ,Brock JE

    更新日期:2017-09-01 00:00:00

  • Fine-needle aspiration biopsy of the mediastinum. A multi-institutional analysis.

    abstract::The combined experience of four university medical centers with fine-needle aspiration biopsy (FNAB) of the mediastinum is reviewed. This series includes 189 cases, with 100 males and 89 females, 6 months to 86 years of age. The majority (71%) of diagnoses were neoplastic with the remainder equally distributed between...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajcp/105.2.168

    authors: Powers CN,Silverman JF,Geisinger KR,Frable WJ

    更新日期:1996-02-01 00:00:00

  • Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations.

    abstract::Twenty cases of inflammatory myofibroblastic tumor (IMT) were studied; 19 involved the lung and 1 the esophagus only. The patients' ages ranged from 3 to 72 years. There were 9 males and 11 females. Involvement of a bronchus was seen in one case and of mediastinal structures in four. Chest pain and dyspnea were common...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.5.538

    authors: Pettinato G,Manivel JC,De Rosa N,Dehner LP

    更新日期:1990-11-01 00:00:00

  • Paravaginal wolffian duct (mesonephros) adenocarcinoma: a light and electron microscopic study.

    abstract::This is a report of an adenocarcinoma of mesonephric origin studied by light microscopy, electron microscopy, and immunocytochemistry. Unlike previous reports, our lesion was located paravaginally and not in the leaves of the broad ligament or in the cervix. The light microscopic features are similar to those of previ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.4.539

    authors: Hinchey WW,Silva EG,Guarda LA,Ordonez NG,Wharton JT

    更新日期:1983-10-01 00:00:00

  • Acute lymphoblastic leukemia-hand mirror variant. Analysis for endogenous retroviral antibodies in bone marrow plasma.

    abstract::Two unusual cases of acute lymphoblastic leukemia-hand mirror variant (ALL-HMV) are presented. One patient demonstrated a mixed immunophenotype with HLA-DR, My7, transferrin receptor surface markers, and terminal deoxynucleotidyl transferase positivity. To the authors' knowledge, this is the first ALL-HMV reported wit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.4.410

    authors: Schumacher HR,Desai SN,McClain KL,Domenico DR,Dizikes GJ,Bird ML

    更新日期:1989-04-01 00:00:00