Fine-needle aspiration biopsy of the mediastinum. A multi-institutional analysis.

Abstract:

:The combined experience of four university medical centers with fine-needle aspiration biopsy (FNAB) of the mediastinum is reviewed. This series includes 189 cases, with 100 males and 89 females, 6 months to 86 years of age. The majority (71%) of diagnoses were neoplastic with the remainder equally distributed between nondiagnostic/unsatisfactory and nonneoplastic lesions. Malignant lymphoma and thymoma were the most frequent primary malignancies. Metastatic tumors represented the majority (60%) of neoplasms identified by FNAB. In 16% of these cases, the primary tumor was not identified. The majority (67%) of metastases were from the lung and were predominantly small cell type (52%). Sixty-six ancillary tests were performed on 51 cases (27%). Histologic correlation was available in 78 of 189 (41%) cases, with a diagnostic sensitivity and specificity of 87% to 88% for the detection of neoplasm and 82% to 83% for distinguishing benign from malignant disease. The positive predictive value for the presence of neoplasm was 97% with three cytologic false positives identified. This series is the largest to date on the utility of FNAB for lesions of the mediastinum.

journal_name

Am J Clin Pathol

authors

Powers CN,Silverman JF,Geisinger KR,Frable WJ

doi

10.1093/ajcp/105.2.168

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

168-73

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

105

pub_type

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