Touch Preps of Products of Conception for Rule-Out Ectopic Pregnancy:  A Viable Alternative to Frozen Section.

Abstract:

OBJECTIVES:Tissue confirmation of the intrauterine location of a pregnancy can be difficult grossly, necessitating a frozen section diagnosis. First-trimester tissue is often scant and can be exhausted by frozen section. We examined 39 endometrial curettings performed for rule-out ectopic pregnancy by touch prep to examine the utility of cytopathology in documenting trophoblast or chorionic villi (products of conception [POC]). METHODS:First-trimester curettage specimens sent to the Massachusetts General Hospital Pathology Departmentreceived a gross examination followed by a touch prep of the area most suspicious for villi. Touch preps were reviewed blinded to the final diagnosis and then compared. RESULTS:Thirty-three of the 39 touch preps and histology specimens were concordant, including all 11 negative histology specimens and 22 of the 28 positive histology specimens. CONCLUSIONS:POC can be diagnosed by touch prep and may offer confirmation of grossly identified villi. Positive predictive value is 100%. Negative touch preps should receive further evaluation.

journal_name

Am J Clin Pathol

authors

Chen AL,Tambouret RH,Roberts DJ

doi

10.1093/ajcp/aqw048

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

752-6

issue

6

eissn

0002-9173

issn

1943-7722

pii

aqw048

journal_volume

145

pub_type

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