Abstract:
:Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with isolated trisomy 4. There were 9 men and 4 women with a median age of 54 years. Median blast count was 84% (range, 24%-93%). Morphologic features varied across five 2008 World Health Organization categories. FLT3 (5/10) and NPM1 (4/10) mutations were observed at a frequency similar to normal-karyotype AML cases. KIT D816V (1/10), RAS (1/11; NRAS), and CEBPA (0/9) mutations were rare or absent. In 11 of 13 cases, complete remission was achieved. In 8 cases, relapse occurred, with median relapse-free survival of 11 months. Median overall survival was 28 months. AML with isolated trisomy 4 is rare and associated with high bone marrow blast counts and an intermediate to poor prognosis. KIT mutations are uncommon.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Bains A,Lu G,Yao H,Luthra R,Medeiros LJ,Sargent RLdoi
10.1309/AJCP7ZC9YQERSKGXsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
387-94issue
3eissn
0002-9173issn
1943-7722pii
137/3/387journal_volume
137pub_type
杂志文章abstract::A very simple method of computer-assisted reporting of surgical pathology (including gross description, microscopic description, and diagnosis) has been developed. This method is based on a modification of the existing microbiology program and files in the comprehensive MedLab Company Pathlab computer system, with the...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/78.3.337
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVES:To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions. METHODS:Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n = 17), and "suspicious for mesothelioma" (n = 4)-were immunostained for CAIX, ...
journal_title:American journal of clinical pathology
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abstract:OBJECTIVES:To characterize error rates for genetic test orders between medical specialties and in different settings by examining detailed order information. METHODS:We performed a retrospective analysis of a detailed utilization management case database, comprising 2.5 years of data and almost 1,400 genetic test orde...
journal_title:American journal of clinical pathology
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abstract:OBJECTIVES:Pure erythroid leukemia (PEL) is exceptionally rare in the pediatric setting. Four pediatric PEL cases with t(1;16)(p31;q24) NFIA-CBFA2T3 were reported previously. We present a case of an infant with PEL presenting with erythroblastic sarcoma and harboring a novel t(1;8)(p31.3;q21.3) NFIA-RUNX1T1 fusion dete...
journal_title:American journal of clinical pathology
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更新日期:2020-12-14 00:00:00
abstract::Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the pa...
journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/84.3.391
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVES:To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays. METHODS:A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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abstract::Cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. Although antibody to HBsAg is found in virtually all following recovery from hepatitis B, a cell-mediated response to HBsAg can...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1976-05-01 00:00:00
abstract::Medicare policies have gradually restricted the scope of pathologist services payable under the rules applicable to physician services. Recent changes applying relative value scales has provided an opportunity for national standardization of pathology codes, and has permitted the introduction of clinical pathology int...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Five patterns of bone marrow infiltration by non-Hodgkin lymphoma or Hodgkin lymphoma are currently recognized, but a true follicular pattern of bone marrow involvement by follicular lymphoma has not been described. In 260 bone marrow trephine biopsy specimens involved by follicular lymphoma, we identified 12 cases wi...
journal_title:American journal of clinical pathology
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更新日期:2002-11-01 00:00:00
abstract::Several laboratory methods are currently available for the detection of barbiturates, but few are suitable for emergency use, The authors evaluated use of an ultraviolet spectrophotometric method as a screening procedure and compared the results with results obtained by other barbiturate methods (colorimetric, gas-li...
journal_title:American journal of clinical pathology
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更新日期:1976-11-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/94.4.390
更新日期:1990-10-01 00:00:00
abstract::Worldwide, infection with hepatitis viruses remains a major clinical and public heath concern. The laboratory is an integral part of the diagnosis of these infections since many of the manifestations are nonspecific, and the various hepatitis viruses show overlapping symptomatology. In this article, we discuss the lab...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/MAUW-9059-DQA6-RMRJ
更新日期:2002-12-01 00:00:00
abstract::The use of rapid, simple tests to detect antibodies to human immunodeficiency virus (HIV) in urine could be valuable for several testing situations, such as in private offices, for epidemiologic surveys, and in developing countries. The authors evaluated the performance of the SUDS HIV type 1 test to detect antibody t...
journal_title:American journal of clinical pathology
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更新日期:1994-02-01 00:00:00
abstract:OBJECTIVES:The metaplastic intestinal epithelium in Barrett esophagus (BE) occasionally contains Paneth cells; however, little is known regarding the prevalence and significance of Paneth cell metaplasia (PCM) in BE. METHODS:We evaluated 757 esophageal biopsy specimens with intestinal metaplasia (IM) for PCM. Outcome ...
journal_title:American journal of clinical pathology
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doi:10.1309/AJCPVUJMCVBC9PKM
更新日期:2015-05-01 00:00:00
abstract::Under carefully controlled conditions in a clinical research ward, conjugated primary bile-acid concentrations were measured by a 125I-radioimmunoassay every eight hours for four days in seven healthy control subjects and ten patients with hepatic disease (five with cirrhosis, three with primary biliary cirrhosis and ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/73.2.196
更新日期:1980-02-01 00:00:00
abstract::Examination of urinary sediment has been recommended as a useful diagnostic aid for renal amyloidosis. This procedure was evaluated in the cases of 57 patients, including 11 with proven renal amyloidosis and 13 considered very likely to have the disease. At least three types of urinary fibrillar material were observed...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
abstract::Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/M6U4B8L6TNAK4G9L
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCP2QZRH4ZNPRDD
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To calculate the incidence of nondiagnostic (ND) colorectal (CR) polyp cases in which deeper tissue sectioning rendered new diagnostic information--particularly adenomas--in 2 laboratories staffed by the same pathologists. METHODS:After initial diagnosis, 100 ND CR polyps from each laboratory were reexamine...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPPXU66QZAZNYN
更新日期:2013-08-01 00:00:00
abstract::The incubation of stored blood in a mixture of inosine, pyruvate, glucose, and phosphate restores the O2 affinity of hemoglobin to physiologic levels, as measured by the configuration of the dissociation curve and the P50. This regeneration of normal hemoglobin function not only is consistent for samples anticoagulate...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/109.4.387
更新日期:1998-04-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2004-01-01 00:00:00
abstract::Antibody to hepatitis B core antigen (anti-HBc) has previously been recognized to be a sensitive marker of hepatitis B virus (HBV) infection. In addition, anti-HBc has recently been suggested to be a surrogate marker for non-A, non-B hepatitis agents in donated blood. The authors studied prospectively the HBV antigen ...
journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/93.1.79
更新日期:1990-01-01 00:00:00
abstract::To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve the HER2 status of tumors demonstrating equivocal amplification. The present study was based on 17 breast core biopsy specimens demonstrating invasive carcinoma with equivocal HER2 amplification, defined as an HER2/chromo...
journal_title:American journal of clinical pathology
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更新日期:2008-03-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/29FP-0QAU-CMJY-BK3U
更新日期:2000-05-01 00:00:00
abstract::Same-day turnaround of pathology specimens is desirable in this era of managed care, and rapid microwave tissue processing produces histologic features of a quality equivalent to overnight processing. We studied whether microwave-assisted rapid tissue processing adversely affects the quality of immunohistochemical sta...
journal_title:American journal of clinical pathology
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更新日期:2006-02-01 00:00:00
abstract::Non-Hodgkin lymphoma (NHL) is more likely to develop in patients with Hodgkin disease (HD) than in the general population. Although reports of synchronous or metachronous HD and NHL are not uncommon in the literature, the biologic relationship of these 2 malignant neoplasms often is unclear. A larger-than-expected fra...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/W1GW-43HT-793U-F86R
更新日期:2004-05-01 00:00:00
abstract::Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids. The enzyme expression is minimal in adult tissues and very high in many cancers. Ulcerative colitis is a chronic inflammatory bowel disease that, when long-standing, is associated with an increased risk of colon cancer. The aim of...
journal_title:American journal of clinical pathology
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更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, and pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqaa118
更新日期:2021-01-04 00:00:00
abstract::Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCP1D8YLCFFTLOW
更新日期:2012-12-01 00:00:00