Pathology consultation on anticoagulation monitoring: factor X-related assays.

Abstract:

OBJECTIVES:To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays. METHODS:A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X-related chromogenic assays. RESULTS:The number of anticoagulants available to clinicians has increased greatly in the past decade. Whether and how these anticoagulants should be monitored are areas of uncertainty for clinicians, which can lead to misuse of laboratory assays and suboptimal patient management. Factor X-related assays are of particular concern because of the similar and often confusing test names. Based on a common clinical case scenario and literature review regarding anticoagulant monitoring, an up-to-date discussion and review of the various factor X-related assays are provided, focusing on the differences in test designs and clinical utilities between the chromogenic anti-Xa and chromogenic factor X activity assays. CONCLUSIONS:Anticoagulation therapy and related laboratory monitoring are rapidly evolving areas of clinical practices. A good knowledge of relevant laboratory assays and their clinical applications is necessary to help optimize patient care.

journal_name

Am J Clin Pathol

authors

Wool GD,Lu CM,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.

doi

10.1309/AJCPR3JTOK7NKDBJ

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

623-34

issue

5

eissn

0002-9173

issn

1943-7722

pii

140/5/623

journal_volume

140

pub_type

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