Abstract:
OBJECTIVES:To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays. METHODS:A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X-related chromogenic assays. RESULTS:The number of anticoagulants available to clinicians has increased greatly in the past decade. Whether and how these anticoagulants should be monitored are areas of uncertainty for clinicians, which can lead to misuse of laboratory assays and suboptimal patient management. Factor X-related assays are of particular concern because of the similar and often confusing test names. Based on a common clinical case scenario and literature review regarding anticoagulant monitoring, an up-to-date discussion and review of the various factor X-related assays are provided, focusing on the differences in test designs and clinical utilities between the chromogenic anti-Xa and chromogenic factor X activity assays. CONCLUSIONS:Anticoagulation therapy and related laboratory monitoring are rapidly evolving areas of clinical practices. A good knowledge of relevant laboratory assays and their clinical applications is necessary to help optimize patient care.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Wool GD,Lu CM,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.doi
10.1309/AJCPR3JTOK7NKDBJsubject
Has Abstractpub_date
2013-11-01 00:00:00pages
623-34issue
5eissn
0002-9173issn
1943-7722pii
140/5/623journal_volume
140pub_type
杂志文章,评审abstract::Although prednisolone is the most common immunosuppressive agent used in renal transplantation, an accurate formulation of the optimal dose regimen remains to be established. A sensitive and precise radioimmunoassay was developed for this purpose. Fifty microliters of 1:20 dilutions of serum or 1:200 dilutions of urin...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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abstract::A primary hepatic tumor with histologic features suggestive of carcinoid tumor is reported, and six previously reported cases reviewed. Tumor cells contained electron dense secretory granules with an average diameter 150-200 nm which demonstrated positive argyrophilic reactions. On immunohistochemistry, chromogranin A...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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pub_type: 杂志文章,评审
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更新日期:1976-06-01 00:00:00
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更新日期:1998-03-01 00:00:00
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更新日期:1995-03-01 00:00:00
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更新日期:1992-03-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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