Prednisolone clearance in renal transplantation.

Abstract:

:Although prednisolone is the most common immunosuppressive agent used in renal transplantation, an accurate formulation of the optimal dose regimen remains to be established. A sensitive and precise radioimmunoassay was developed for this purpose. Fifty microliters of 1:20 dilutions of serum or 1:200 dilutions of urine were incubated at room temperature for two hours with 130 pg of 3H-prednisolone (150muCi/microgram) and a rabbit antiserum against prednisolone (1:1,600 dilution). Serial prednisolone clearances (Cp) for ten renal transplant patients representing variable allograft functions were compared with their corresponding creatine clearances (Cer). The data show that renal metabolism of prednisolone is well correlated with Ccr. Increasing (decreasing) Ccr is accompanied by increasing (decreasing) Cp. The availability of an assay for serum prednisolone, together with a knowledge of the ratio between these two clearances, may prove useful for regulating therapy in renal transplant patients.

journal_name

Am J Clin Pathol

authors

Woo J,Floyd M,Master G,Cannon DC

doi

10.1093/ajcp/73.6.804

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

804-8

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

73

pub_type

杂志文章
  • Effects of cigarette smoking on intramyocardial arteries and arterioles in man.

    abstract::Proliferative lesions, which include collagen, elastic fibers and abnormally oriented muscle fibers, were found to develop in intramyocardial arteries more rapidly with age in cigarette smokers than in nonsmokers. The study attempted to determine whether these lesions reduce perfusion pressures in the subendocardial z...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.4.493

    authors: Naeye RL,Truong LD

    更新日期:1977-10-01 00:00:00

  • Epithelial cell atypia in bronchoalveolar lavage specimens from lung transplant recipients.

    abstract::In lung transplant recipients, bronchoalveolar lavage (BAL) is mainly performed to detect infectious agents. However, in addition to microorganisms, epithelial cell atypia may be identified, and determination of its significance is necessary. Specimens obtained at BAL in lung and heart-lung transplant recipients (LTRs...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/112.2.204

    authors: Ohori NP

    更新日期:1999-08-01 00:00:00

  • Spectrophotometric detection of RT-PCR-amplified BCR/ABL fusion transcripts. A survey performed on archival hematologic slides.

    abstract::We describe a method of spectrophotometric detection of BCR/ABL chimeric sequences amplified by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), enabling the use of archival hematologic slides as RNA sources. Multiplex PCR amplified b3a2, b2a2, and e1a2 break points of the BCR/ABL translocation and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.4.383

    authors: Attadia V,Alosi M,Improta S,Zagonel V,Martinazzo G,Carbone A,Pinto A

    更新日期:1997-10-01 00:00:00

  • The neuroendocrine system and its tumors: an overview.

    abstract::Neuroendocrine tumors comprise a family of neoplasms with a wide range of morphologic, functional, and behavioral characteristics. Their diagnosis depends on the recognition of characteristic morphologic features and on the presence of markers indicative of neuroendocrine differentiation. Neuroendocrine tumors can be ...

    journal_title:American journal of clinical pathology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1309/7GR5-L7YW-3G78-LDJ6

    authors: DeLellis RA

    更新日期:2001-06-01 00:00:00

  • Mucosal invasion in campylobacter enteritis.

    abstract::Campylobacter fetus subspecies jejuni has recently been recognized as a significant cause of enteritis in humans. The organism has been previously postulated to cause illness by direct invasion of the mucosa of the gastrointestinal tract, but this has not been documented. Reported is a case of Campylobacter enteritis ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.5.706

    authors: Duffy MC,Benson JB,Rubin SJ

    更新日期:1980-05-01 00:00:00

  • Fetal-maternal hemorrhage detection in Ontario.

    abstract::The results from fetal-maternal hemorrhage (FMH) detection and quantitation external quality assessment surveys conducted in Ontario indicate that the rosette test had a sensitivity and specificity for an FMH of more than 10 mL of 1.0 and 0.75, respectively, compared with 0.96 and 0.92, respectively, for acid elution....

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3U97-V732-7JBD-PAYN

    authors: Lafferty JD,Raby A,Crawford L,Linkins LA,Richardson H,Crowther M

    更新日期:2003-01-01 00:00:00

  • Establishing Evidence-Based Statistical Quality Control Practices.

    abstract:OBJECTIVES:To establish an objective, scientific, evidence-based process for planning statistical quality control (SQC) procedures based on quality required for a test, precision and bias observed for a measurement procedure, probabilities of error detection and false rejection for different control rules and numbers o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy158

    authors: Westgard JO,Westgard SA

    更新日期:2019-03-01 00:00:00

  • Atypical glandular cells of undetermined significance. Diagnostic accuracy and interobserver variability using select cytologic criteria.

    abstract::Histologic follow-up of patients with the Bethesda system cervical-vaginal diagnosis of atypical glandular cells of undetermined significance (AGUS), "favor endocervical origin", or "not otherwise specified" (NOS) shows a high percentage of clinically significant (neoplastic or preneoplastic) lesions. Using the criter...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.3.299

    authors: Raab SS,Snider TE,Potts SA,McDaniel HL,Robinson RA,Nelson DL,Sigman JD,Thomas PA

    更新日期:1997-03-01 00:00:00

  • Spindle and histiocytoid (epithelioid) hemangioendothelioma. Primary in lymph node.

    abstract::A 52-year-old woman presented with a solid spindle cell primary tumor of the lymph node. On light microscopic examination, mitoses and cellular atypia were absent. Electron-microscopic studies showed endothelial cell differentiation. Intracytoplasmic localization of Factor VIII-related antigen was demonstrated by the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/85.6.731

    authors: Silva EG,Phillips MJ,Langer B,Ordonez NG

    更新日期:1986-06-01 00:00:00

  • Hodgkin's disease of the esophagus.

    abstract::A 61-year-old man with acquired immunodeficiency syndrome (AIDS) sought care because of the onset of progressive dysphagia. He was found to have a perforated, fungating esophageal mass. The combined histologic and immunologic findings were diagnostic of Hodgkin's disease, nodular sclerosis type, lymphocyte-depleted va...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.5.593

    authors: Gelb AB,Medeiros LJ,Chen YY,Weiss LM,Weidner N

    更新日期:1997-11-01 00:00:00

  • Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results.

    abstract::The ATHENA (Addressing THE Need for Advanced HPV Diagnostics) HPV study evaluated the clinical usefulness of the cobas HPV Test (Roche Molecular Systems, Pleasanton, CA) for high-risk human papillomavirus (HR-HPV) testing (14 HR types) and individual HPV-16/HPV-18 genotyping in women undergoing routine cervical cytolo...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1309/AJCPTUS5EXAS6DKZ

    authors: Wright TC Jr,Stoler MH,Sharma A,Zhang G,Behrens C,Wright TL,ATHENA (Addressing THE Need for Advanced HPV Diagnostics) Study Group.

    更新日期:2011-10-01 00:00:00

  • Phagocytic myeloma cells.

    abstract::A case of a patient with otherwise typical multiple myeloma whose myeloma cells were phagocytic is described. Phagocytosis of erythrocytes, erythrocytic precursors, lymphocytes, and platelets was found. Ingestion of latex particles by myeloma cells was demonstrated in vitro. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.6.722

    authors: Fitchen JH,Lee S

    更新日期:1979-06-01 00:00:00

  • Visual memory effects on intraoperator study design: determining a minimum time gap between case reviews to reduce recall bias.

    abstract:OBJECTIVES:The objective of this research was to determine test intervals between intraoperator case reviews to minimize the impact of recall. METHODS:Three pathologists were presented with a group of 120 slides and subsequently challenged with a study set of 120 slides after 2-week and 4-week intervals. The challenge...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPUC3TYMS3QOBM

    authors: Campbell WS,Talmon GA,Foster KW,Baker JJ,Smith LM,Hinrichs SH

    更新日期:2015-03-01 00:00:00

  • The use of fine needle aspiration cytology for the distinction of pancreatic mucinous neoplasia.

    abstract::Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/Y16QCXE3YGMXX19Q

    authors: Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

    更新日期:2008-01-01 00:00:00

  • Extensively keratinized squamous intraepithelial lesions of the cervix are difficult to grade.

    abstract::We tested the hypothesis that extensively keratinized squamous intraepithelial lesions (SILs) are difficult to grade precisely by identifying 100 Papanicolaou smears with a keratinizing SIL that had been originally judged difficult to grade. Of these, 65 were confirmed as low-grade SIL (LSIL) or high-grade SIL (HSIL) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/RQBN-Y51J-CJTK-P9H5

    authors: Faquin WC,Brown FM,Krane JF,Renshaw AA,Cibas ES

    更新日期:2001-01-01 00:00:00

  • Current concepts on Riedel thyroiditis.

    abstract::Riedel thyroiditis (RT) is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. The etiologic mechanisms underlying RT are unclear: the prevailing view is that it is part of a generalized fibroinflammatory process also involving other organs. The clinical manifestations of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/NUU88VAFR9YEHKNA

    authors: Papi G,LiVolsi VA

    更新日期:2004-06-01 00:00:00

  • The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors.

    abstract::The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.3.286

    authors: Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

    更新日期:1998-03-01 00:00:00

  • Increased numbers of lymphocytes with single class surface immunoglobulins in Hodgkin's disease.

    abstract::Lymphocyte populations with abnormal kappa/lambda ratios have been described previously in B-cell non-Hodgkin's lymphomas and in lymphoid hyperplasia. The authors studied 12 patients in whom lymph nodes diagnostic of Hodgkin's disease contained evidence of monoclonal lymphocyte proliferation. One patient subsequently ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.6.674

    authors: Bain GO,Bain VG

    更新日期:1984-12-01 00:00:00

  • Monoclonal antibody, Mab 12C3, is a sensitive immunohistochemical marker of early malignant change in epithelial ovarian tumors.

    abstract::A murine monoclonal antibody (MAb 12C3) that is specific to human ovarian carcinomas was generated by immunizing mice with a human ovarian germinoma cell line (JOHYC-2). The antigen distribution that was defined by MAb 12C3 in normal and malignant human tissues was analyzed by immunohistochemistry on paraffin-embedded...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.3.288

    authors: Yamada K,Ohkawa K,Joh K

    更新日期:1995-03-01 00:00:00

  • Utility of acid-fast staining for detection of mycobacteria in cutaneous granulomatous tissue reactions.

    abstract:OBJECTIVES:Ancillary molecular testing on tissue is available for mycobacterial disease; however, judicious use of highly sensitive tests, such as polymerase chain reaction (PCR) and sequencing, should be guided by histologic parameters. We sought to investigate the utility of performing acid-fast stains (AFS) on skin ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPNM3J9TOIBRSK

    authors: Laga AC,Milner DA Jr,Granter SR

    更新日期:2014-04-01 00:00:00

  • Cross-reactivity with normal antigens in commercial anti-CEA sera, used for immunohistology. The need for tissue controls and absorptions.

    abstract::The demonstration of carcinoembryonic antigen (CEA) in serum and in tissue sections may be of value in diagnosis and follow-up of several malignant tumors. Anti-CEA sera, however, cross-react with normal antigens, also present in tumors. The staining patterns of three commercially produced anti-CEA sera were investiga...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.1.25

    authors: Nap M,ten Hoor KA,Fleuren GJ

    更新日期:1983-01-01 00:00:00

  • Determination of terminal deoxynucleotidyl transferase on bone marrow smears by immunoperoxidase.

    abstract::Terminal deoxynucleotidyl transferase (TdT) is a marker of lymphoblastic disorders. Previously, the technique for determining TdT on smears was by indirect immunofluorescence. An immunoperoxidase procedure for detecting TdT on smears is reported. Results are in a comparable range with the indirect immunofluorescent te...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.2.174

    authors: Stass SA,Dean L,Peiper SC,Bollum FJ

    更新日期:1982-02-01 00:00:00

  • The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas.

    abstract::Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPF4O0ADKFMGRJ

    authors: Ross DS,Liu YF,Pipa J,Shin SJ

    更新日期:2013-01-01 00:00:00

  • Molecular and Immunohistochemical Analysis of Mucinous Cystic Neoplasm of the Liver.

    abstract:OBJECTIVES:Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa115

    authors: Van Treeck BJ,Lotfalla M,Czeczok TW,Mounajjed T,Moreira RK,Allende DS,Reid MD,Naini BV,Westerhoff M,Adsay NV,Kerr SE,Rizvi SH,Smoot RL,Liu Y,Davila J,Graham RP

    更新日期:2020-11-04 00:00:00

  • Daily Management System of the Henry Ford Production System: QTIPS to Focus Continuous Improvements at the Level of the Work.

    abstract:OBJECTIVES:To support our Lean culture of continuous improvement, we implemented a daily management system designed so critical metrics of operational success were the focus of local teams to drive improvements. METHODS:We innovated a standardized visual daily management board composed of metric categories of Quality,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPLQYMOFWU31CK

    authors: Zarbo RJ,Varney RC,Copeland JR,D'Angelo R,Sharma G

    更新日期:2015-07-01 00:00:00

  • Usefulness of Dual Immunohistochemistry Staining in Detection of Hairy Cell Leukemia in Bone Marrow.

    abstract:OBJECTIVES:We evaluated efficacy of two dual immunohistochemistry (IHC) staining assays in assessing hairy cell leukemia (HCL) involvement in core biopsies and compared the results with concurrently collected flow cytometric data. METHODS:Overall, 148 patients with HCL (123 male, 25 female; mean age: 59.8 years; range...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz171

    authors: Gupta GK,Sun X,Yuan CM,Stetler-Stevenson M,Kreitman RJ,Maric I

    更新日期:2020-02-08 00:00:00

  • The morphologic and immunophenotypic assessment of the lymphocytosis accompanying Bordetella pertussis infection.

    abstract::Bordetella pertussis (Bp) infection in infants and young children can be associated with a significant increase in small lymphocytes with convoluted and cleaved nuclei (SLCCN) in the peripheral blood (PB). Buffy coat smears were studied that were prepared from the PB of 11 children with documented Bp infection, whose ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.6.809

    authors: Kubic VL,Kubic PT,Brunning RD

    更新日期:1991-06-01 00:00:00

  • The expression of histocompatibility-related leukocyte antigens in the pathway to cervical carcinoma.

    abstract::The major histocompatibility complex probably plays a crucial role in the efficacy of the cellular immune response against virally infected cervical diseases. Therefore, the allele-specific histocompatibility-related leukocyte antigens (HLA) class I and II expression on normal (n = 10), premalignant (n = 25), and mali...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.1.5

    authors: Hilders CG,Houbiers JG,Krul EJ,Fleuren GJ

    更新日期:1994-01-01 00:00:00

  • Peliosis of the spleen.

    abstract::Peliosis of the spleen was found in 10 out of 1,200 cases autopsied from 1977 through 1980 in our laboratory. Eight such cases had no peliosis of the liver. Histologically, it was noticed that the parafollicular areas were the most common sites of the lesions, and this feature seemed to be important for the histologic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.6.708

    authors: Tada T,Wakabayashi T,Kishimoto H

    更新日期:1983-06-01 00:00:00

  • Expression of p63 in thymomas and normal thymus.

    abstract::The p63 gene, a member of the p53 family, is an epithelial marker expressed in embryonic ectoderm, breast myoepithelium, prostate, oral epithelium, epidermis, and urothelium. The DeltaN-p63 isoforms of p63, which are believed to behave as oncogenes, are expressed in squamous cell carcinoma, basal cell carcinoma, and t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/2GAYKPDDM85P2VEW

    authors: Dotto J,Pelosi G,Rosai J

    更新日期:2007-03-01 00:00:00