Distribution of Lipiodol and evidence for tumor necrosis in hepatocellular carcinoma.

Abstract:

:To study the distribution and thromboembolic effect of Ultrafluid Lipiodol, 15 surgically removed hepatocellular carcinomas with selective intraarterial Lipiodol injection 7 to 10 days before surgery and 15 noninjected controls were studied radiologically and histologically. Tissue blocks were processed with an en bloc silver impregnation technique for Lipiodol localization in histologic sections. Lipiodol was distributed evenly in tumors measuring less than 5 cm in diameter and peripherally in tumors measuring 10 cm or more. Lipiodol droplets were mainly extracellular. There was no difference in tumor architecture or in hemorrhage and necrosis scores between Lipiodol-injected cases and negative controls (1.18 versus 0.92). Similarly, in injected cases, no differences were observed between Lipiodol-positive and Lipiodol-negative areas (scores of x-ray Lipiodol-positive versus Lipiodol-negative areas: 1.17 versus 1.36; scores of microscopic Lipiodol-positive versus Lipiodol-negative areas: 1.18 versus 1.14). Lipiodol-negative but hypodense areas examined by x-ray proved to be necrosis or fibrosis with or without viable tumor islands. Lipiodol has no thromboembolic effects. The uneven Lipiodol distribution may account for its failure as a carrier for chemotherapeutic agents in large tumors.

journal_name

Am J Clin Pathol

authors

Arnold MM,Kreel L,Wallace AC,Li AK

doi

10.1093/ajcp/97.3.405

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

405-10

issue

3

eissn

0002-9173

issn

1943-7722

journal_volume

97

pub_type

杂志文章
  • Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease.

    abstract::Under carefully controlled conditions in a clinical research ward, conjugated primary bile-acid concentrations were measured by a 125I-radioimmunoassay every eight hours for four days in seven healthy control subjects and ten patients with hepatic disease (five with cirrhosis, three with primary biliary cirrhosis and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.2.196

    authors: Engelking LR,Dasher CA,Hirschowitz BI

    更新日期:1980-02-01 00:00:00

  • Intrauterine infarction of a pulmonary segment in a full-term newborn. A case report.

    abstract::Intrauterine pulmonary infarction is extremely rare. In a series of 775 stillborn and newborn infants, only a few cases of acute pulmonary infarction were reported. The authors present the findings from a full-term infant who died at 9 hours of age of a chronic pulmonary infarction. Several pathogenic mechanisms, incl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.6.701

    authors: Mirkin LD,Wong RC

    更新日期:1993-12-01 00:00:00

  • Comparison of complement fixation and fluorescent immunoassay (FIAX) for measuring antibodies to cytomegalovirus and herpes simplex virus.

    abstract::An automated fluorescent immunoassay system (FIAX) was compared with complement fixation (CF) for measuring antibodies to cytomegalovirus (CMV) and herpes simplex virus (HSV) in clinical specimens. Compared with CF the specificity of FIAX (ability to detect a negative titer) was 95% for CMV and 92% for HSV. The sensit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.3.305

    authors: Friedman HM,Tustin NB,Hitchings MM,Plotkin SA

    更新日期:1981-09-01 00:00:00

  • The new reticulocyte parameter (RET-Y) of the Sysmex XE 2100: its use in the diagnosis and monitoring of posttreatment sideropenic anemia.

    abstract::To verify their clinical usefulness in diagnosis and early response to therapy of sideropenic anemia, we compared the behavior of the reticulocyte parameter (RET-Y), a raw measure dependent on size and content of the cell, generated by the Sysmex XE 2100, with the mean reticulocyte volume (MCVr) and mean reticulocyte ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/W652-95DT-UWK7-U1HH

    authors: Buttarello M,Temporin V,Ceravolo R,Farina G,Bulian P

    更新日期:2004-04-01 00:00:00

  • Susceptibility testing with anaerobic blood culture isolates. Comparison of a rapid, direct methods with standardized method.

    abstract::The results of a direct anaerobic susceptibility testing method were compared with those of a standardized method. Seventy-three blood culture isolates and eight antimicrobial agents were used. The results of the direct and standardized testing methods were within one two-fold dilution for 95.2% of the 584 anaerobe-an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.4.558

    authors: Murray PR,Christman JL

    更新日期:1980-04-01 00:00:00

  • Mucosa-associated lymphoid tissue of the thymus hyperplasia vs lymphoma.

    abstract::In the thymus, the relationship between lymphofollicular hyperplasia and mucosa-associated lymphoid tissue (MALT)-type lymphoma is uncertain. We analyzed 14 cases with a diagnosis of thymic follicular hyperplasia in patients with connective tissue disease (n = 2), myasthenia gravis (n = 11), or both (n = 1). In 11 cas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/G3AC-P7K8-2JNK-8C3U

    authors: Parrens M,Dubus P,Danjoux M,Jougon J,Brousset P,Velly JF,de Mascarel A,Merlio JP

    更新日期:2002-01-01 00:00:00

  • Carbonic anhydrase IX (CAIX) does not differentiate between benign and malignant mesothelium.

    abstract:OBJECTIVES:To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions. METHODS:Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n = 17), and "suspicious for mesothelioma" (n = 4)-were immunostained for CAIX, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP8BJ8CJXUEHZD

    authors: Ananthanarayanan V,Tretiakova M,Husain AN,Krausz T,Antic T

    更新日期:2014-07-01 00:00:00

  • Immunohistochemical detection of XIAP in mesothelium and mesothelial lesions.

    abstract::We examined benign and malignant mesothelial tissue samples for the presence of X-linked inhibitor of apoptosis protein (XIAP), a potent constituent of the inhibitor of apoptosis family of caspase inhibitors. We subjected 55 sections (31 malignant mesotheliomas, 2 well-differentiated peritoneal mesotheliomas, 13 pleur...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/LX7NFRDXY1JQF9R1

    authors: Wu M,Sun Y,Li G,Desman G,Wang B,Gil J,Burstein DE

    更新日期:2007-11-01 00:00:00

  • Platelet size in health and hematologic disease.

    abstract::In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart dise...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.2.150

    authors: Bessman JD,Williams LJ,Gilmer PR Jr

    更新日期:1982-08-01 00:00:00

  • Chronic myelogenous leukemia, BCR-ABL1+.

    abstract::Session 1 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology focused on chronic myelogenous leukemia, BCR-ABL1+ (CML). CML is a myeloproliferative neoplasm arising at the level of a pluripotent stem cell and consistently associated with the BCR-ABL1 fusion gene. CML most ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPUN89CXERVOVH

    authors: Vardiman JW

    更新日期:2009-08-01 00:00:00

  • Automated analysis of multidimensional flow cytometry data improves diagnostic accuracy between mantle cell lymphoma and small lymphocytic lymphoma.

    abstract::Mantle cell lymphoma (MCL) and small lymphocytic lymphoma (SLL) exhibit similar but distinct immunophenotypic profiles. Many cases can be diagnosed readily by flow cytometry (FCM) alone; however, ambiguous cases are frequently encountered and necessitate additional studies, including immunohistochemical staining for c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPMMLQ67YOMGEW

    authors: Zare H,Bashashati A,Kridel R,Aghaeepour N,Haffari G,Connors JM,Gascoyne RD,Gupta A,Brinkman RR,Weng AP

    更新日期:2012-01-01 00:00:00

  • A unique bone-like variant of alkaline phosphatase.

    abstract::The authors describe an unusual variant of alkaline phosphatase (ALP) discovered in a patient with a 90-fold increase in serum ALP. The variant ALP was indistinguishable from the bone isoenzyme when subjected to chemical inhibition, heat inactivation, lectin precipitation, and routine electrophoresis. However, treatme...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.5.749

    authors: Schreiber WE,Gorecki T,Bernstein V

    更新日期:1991-05-01 00:00:00

  • Comparison of three methods for measuring factor VIII levels in plasma.

    abstract::We compared 1-stage clot-based, chromogenic, and immunoassay methods for measuring factor VIII in plasma with a focus on the measurement of elevated levels of factor VIII. The chromogenic assay showed the best interassay imprecision for factor VIII levels near 150 IU/dL. The best correlation was between the 1-stage cl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/C8T8-YNB4-G3W4-5PRF

    authors: Chandler WL,Ferrell C,Lee J,Tun T,Kha H

    更新日期:2003-07-01 00:00:00

  • Current concepts on Riedel thyroiditis.

    abstract::Riedel thyroiditis (RT) is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. The etiologic mechanisms underlying RT are unclear: the prevailing view is that it is part of a generalized fibroinflammatory process also involving other organs. The clinical manifestations of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/NUU88VAFR9YEHKNA

    authors: Papi G,LiVolsi VA

    更新日期:2004-06-01 00:00:00

  • Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of thymic epithelial neoplasms.

    abstract::Primary thymic epithelial neoplasms have been the subject of much controversy in recent years owing to the difficulties posed by these tumors for precise histopathologic typing and prognostication. A number of classification schemes using different terminology have been proposed, none of which has satisfactorily manag...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/111.6.826

    authors: Suster S,Moran CA

    更新日期:1999-06-01 00:00:00

  • Morphologically occult systemic mastocytosis in bone marrow: clinicopathologic features and an algorithmic approach to diagnosis.

    abstract:OBJECTIVES:Bone marrow (BM) biopsy specimens involved by systemic mastocytosis (SM) typically show multifocal, compact, dense aggregates of spindled mast cells (MCs). However, some cases lack aggregate formation and fulfill the World Health Organization 2008 criteria for SM, based on minor criteria. METHODS:We identif...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPSGQ71GJQQACL

    authors: Reichard KK,Chen D,Pardanani A,McClure RF,Howard MT,Kurtin PJ,Wood AJ,Ketterling RP,King RL,He R,Morice WG,Hanson CA

    更新日期:2015-09-01 00:00:00

  • A primer on the cost of quality for improvement of laboratory and pathology specimen processes.

    abstract::In today's environment, many laboratories and pathology practices are challenged to maintain or increase their quality while simultaneously lowering their overall costs. The cost of improving specimen processes is related to quality, and we demonstrate that actual costs can be reduced by designing "quality at the sour...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPSMQYAF6X1HUT

    authors: Carlson RO,Amirahmadi F,Hernandez JS

    更新日期:2012-09-01 00:00:00

  • Management training for pathology residents. I. Results of a national survey.

    abstract::The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8%...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.5.559

    authors: Brugnara C,Fenton T,Winkelman JW

    更新日期:1994-05-01 00:00:00

  • Current issues in breast cytopathology.

    abstract::This article explores 3 aspects of breast diagnosis that are currently under investigation and about which our thinking has recently undergone considerable reshaping. The trend toward more frequent evaluation of clinically subtle lesions has suggested that it might be necessary to understand thefine-needle aspiration ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/29FP-0QAU-CMJY-BK3U

    authors: Stanley MW,Sidawy MK,Sanchez MA,Stahl RE,Goldfischer M

    更新日期:2000-05-01 00:00:00

  • Evaluation of real-time clinical decision support systems for platelet and cryoprecipitate orders.

    abstract:OBJECTIVES:To evaluate cryoprecipitate and platelet ordering practices after the implementation of real-time clinical decision support systems (CDSSs) in a computerized physician order entry (CPOE) system. METHODS:Uniform platelet and cryoprecipitate transfusion thresholds were implemented at 11 hospitals in a regiona...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1309/AJCP1OSRTPUJE9XS

    authors: Collins RA,Triulzi DJ,Waters JH,Reddy V,Yazer MH

    更新日期:2014-01-01 00:00:00

  • Differences in Performance Characteristics Among Four High-Throughput Assays for the Detection of Antibodies Against SARS-CoV-2 Using a Common Set of Patient Samples.

    abstract:OBJECTIVES:Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has experienced a changing landscape of available assays coupled with uncertainty surrounding performance characteristics. Studies are needed to directly compare multiple commercially available assays. METHODS:Residual serum ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa200

    authors: Manthei DM,Whalen JF,Schroeder LF,Sinay AM,Li SH,Valdez R,Giacherio DA,Gherasim C

    更新日期:2020-10-09 00:00:00

  • Intrinsic factor, free of R proteins, can be prepared from mouse stomach and used in a ligand assay specific for "true" cobalamin.

    abstract::A ligand assay specific for cobalamin that uses mouse stomach as the source of intrinsic factor has been developed. When mouse stomach extract incubated with radiocobalamin is fractionated by gel chromatography, the radioactive complex elutes as a single peak with apparent molecular weight of 54,900. Formation of the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.6.786

    authors: Reynoso G,Tuggey R,Hansen H,Fontelo PA,Konopka S,Miller JT

    更新日期:1981-06-01 00:00:00

  • Application of adrenocorticotropin assays in a routine clinical laboratory.

    abstract::The radioimmunoassay of ACTH was used in a routine laboratory to localize the site of the lesion in 20 patients with Cushing's syndrome. Eight of the patients had no detectable circulating ACTH and had adrenal tumors removed, 12 had high levels and were diagnosed as having pituitary Cushing's syndrome. Very high level...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.5.618

    authors: Broughton A

    更新日期:1975-11-01 00:00:00

  • Spindle and histiocytoid (epithelioid) hemangioendothelioma. Primary in lymph node.

    abstract::A 52-year-old woman presented with a solid spindle cell primary tumor of the lymph node. On light microscopic examination, mitoses and cellular atypia were absent. Electron-microscopic studies showed endothelial cell differentiation. Intracytoplasmic localization of Factor VIII-related antigen was demonstrated by the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/85.6.731

    authors: Silva EG,Phillips MJ,Langer B,Ordonez NG

    更新日期:1986-06-01 00:00:00

  • Clinical impact of point-of-care vs laboratory measurement of anticoagulation.

    abstract::Patients using anticoagulation point-of-care (POC) monitors are advised to periodically test these systems against laboratory methods to monitor performance. The international normalized ratio (INR), however, can vary between test systems owing to different instrument-reagent combinations. In a randomized study evalua...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Sunderji R,Gin K,Shalansky K,Carter C,Chambers K,Davies C,Schwartz L,Fung A

    更新日期:2005-02-01 00:00:00

  • Acquired von Willebrand disease due to inhibitor of human myeloma protein specific for von Willebrand factor.

    abstract::A patient with acquired von Willebrand disease associated with multiple myeloma (IgG-lambda) is described. Mixture of his plasma or IgG fraction with washed control platelets resulted in the inhibition of aggregation with ristocetin, but mixture of control plasma or IgG fraction with washed patient platelets showed no...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.5.663

    authors: Mohri H,Noguchi T,Kodama F,Itoh A,Ohkubo T

    更新日期:1987-05-01 00:00:00

  • A new solid phase passive hemagglutination test for IgM antibody to hepatitis B core antigen.

    abstract::There is a need for a simple, sensitive, specific, and inexpensive test for immunoglobulin M antibody to hepatitis B core antigen (anti-HBc IgM). A solid phase passive hemagglutination test (SP-PHA) was developed for this purpose and compared with the enzyme-linked immunosorbent assay (ELISA) test. Hepatitis B core an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.2.267

    authors: Petchclai B,Khupulsup K,Kurathong S

    更新日期:1987-02-01 00:00:00

  • Detection of chlamydial cervicitis by Papanicolaou stained smears and culture.

    abstract::The ability of the cervical Papanicolaou (Pap) smear to detect cervicitis associated with Chlamydia trachomatis was investigated. Cultures and cervical cytology samples were obtained from 487 women seen at the Mayo Clinic Department of Obstetrics and Gynecology and at the Sexually Transmitted Disease clinic of the Olm...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.4.421

    authors: Dorman SA,Danos LM,Wilson DJ,Noller KL,Malkasian GD,Goellner JR,Smith TF

    更新日期:1983-04-01 00:00:00

  • To what extent are free testosterone (FT) values reproducible between the two Washingtons, and can calculated FT be used in lieu of expensive direct measurements?

    abstract::Free testosterone (FT) measurement by equilibrium dialysis and liquid chromatography-tandem mass spectroscopy (LCMS/MS) is the "gold standard." We hypothesized that calculated FT values could substitute for measured values; compared FT results reported by Walter Reed Army Medical Center (WRAMC), Washington, DC, with r...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1309/6PYTC60ALVQQ59RQ

    authors: DeVan ML,Bankson DD,Abadie JM

    更新日期:2008-03-01 00:00:00

  • Issues in cerebrospinal fluid management. CSF Venereal Disease Research Laboratory testing.

    abstract::Three policies for decreasing unnecessary cerebrospinal fluid (CSF) management Venereal Disease Research Laboratory (VDRL) tests were compared. The first policy attempted to educate physicians about the use of serologic tests for diagnosing neurosyphilis but allowed the CSF VDRL to be performed either as a screening t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.3.397

    authors: Albright RE Jr,Christenson RH,Emlet JL,Graham CB 3rd,Estevez EG,Wilson ML,Reller LB,Schneider KA

    更新日期:1991-03-01 00:00:00