Application of adrenocorticotropin assays in a routine clinical laboratory.

Abstract:

:The radioimmunoassay of ACTH was used in a routine laboratory to localize the site of the lesion in 20 patients with Cushing's syndrome. Eight of the patients had no detectable circulating ACTH and had adrenal tumors removed, 12 had high levels and were diagnosed as having pituitary Cushing's syndrome. Very high levels of plasma ACTH were found in eight patients who had primary adrenal insufficiency, while ACTH was undetectable in ten patients with secondary hypoadrenalism. The routine use of this assay in endocrinology should reduce the hospitalization of patients under investigation for disorders of the pituitary--adrenal axis. Eight patients who had the ectopic ACTH syndrome and carcinoma of the lung were found to have very high levels of ACTH with no diurnal variation. Forty-seven patients with oat-cell carcinoma but without evidence of the ectopic ACTH syndrome had normal ACTH levels. A possible role of ACTH and other peptide hormones as tumor markers is mentioned.

journal_name

Am J Clin Pathol

authors

Broughton A

doi

10.1093/ajcp/64.5.618

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

618-24

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

64

pub_type

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