Abstract:
:Two atypical human non-Hodgkin's lymphomas (NHLs) that exhibited unusual genotypic and in situ immunophenotypic abnormalities are described. Immunophenotypically, both NHLs lacked surface Ig heavy chains. With the exception of the MB2 B-cell-associated antigen, no B- and T-cell differentiation antigen was detected in case 1. NHL 2 failed to show evidence of clonality by immunohistochemical analysis but revealed the presence of many B-lymphocytes with an abnormal phenotypic profile: CD19+, CD20+, CD22+, kappa-, lambda-, CD9-, CD10-, CD21-, and CD24-. Genotypic analysis indicated that both lymphomas derived from anomalously matured pre-B-cells that had rearranged the lambda or kappa light chain genes but not the Ig heavy chain gene. The neoplastic cells of the two NHLs resemble the light chain-only B-cells recently discovered, following Epstein-Barr virus immortalization, in the human bone marrow. The authors' data confirm, therefore, the existence of the light chain-only B-cells in the human hematopoietic compartment. Moreover, their results emphasize the conclusive role of the immunogenotypic analysis in defining clonality, lineage, and maturation abnormalities of such atypical NHLs.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
De Re V,Carbone A,Dolcetti R,Tirelli U,Folegotto C,Boiocchi Mdoi
10.1093/ajcp/94.4.390subject
Has Abstractpub_date
1990-10-01 00:00:00pages
390-6issue
4eissn
0002-9173issn
1943-7722journal_volume
94pub_type
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:2013-01-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:American journal of clinical pathology
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