Genotypic and immunophenotypic characterization of two human light chain-only B-cell non-Hodgkin's lymphomas.

Abstract:

:Two atypical human non-Hodgkin's lymphomas (NHLs) that exhibited unusual genotypic and in situ immunophenotypic abnormalities are described. Immunophenotypically, both NHLs lacked surface Ig heavy chains. With the exception of the MB2 B-cell-associated antigen, no B- and T-cell differentiation antigen was detected in case 1. NHL 2 failed to show evidence of clonality by immunohistochemical analysis but revealed the presence of many B-lymphocytes with an abnormal phenotypic profile: CD19+, CD20+, CD22+, kappa-, lambda-, CD9-, CD10-, CD21-, and CD24-. Genotypic analysis indicated that both lymphomas derived from anomalously matured pre-B-cells that had rearranged the lambda or kappa light chain genes but not the Ig heavy chain gene. The neoplastic cells of the two NHLs resemble the light chain-only B-cells recently discovered, following Epstein-Barr virus immortalization, in the human bone marrow. The authors' data confirm, therefore, the existence of the light chain-only B-cells in the human hematopoietic compartment. Moreover, their results emphasize the conclusive role of the immunogenotypic analysis in defining clonality, lineage, and maturation abnormalities of such atypical NHLs.

journal_name

Am J Clin Pathol

authors

De Re V,Carbone A,Dolcetti R,Tirelli U,Folegotto C,Boiocchi M

doi

10.1093/ajcp/94.4.390

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

390-6

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

94

pub_type

杂志文章
  • Coexpression of cytokeratins typical for columnar and squamous differentiation in sinonasal inverted papillomas.

    abstract::Cytokeratin (CK) expression was studied in 22 sinonasal inverted papillomas. Columnar (respiratory) epithelium in inverted papillomas abundantly expressed CK7, CK8, CK18, and CK19. Immunoreactivity for CK5/14 and CK17 was found in basal and parabasal/suprabasal cells. Transitional (cuboidal) and squamous epithelium in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/TH5J-T1Q6-9QJR-8CDK

    authors: Schwerer MJ,Kraft K,Baczako K,Maier H

    更新日期:2001-05-01 00:00:00

  • Hemolytic disease of the newborn due to anti-C and anti-G masquerading as anti-D.

    abstract::After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurren...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.6.769

    authors: Yesus YW,Akhter JE

    更新日期:1985-12-01 00:00:00

  • Comparison of anti-estrogen receptor antibodies SP1, 6F11, and 1D5 in breast cancer: lower 1D5 sensitivity but questionable clinical implications.

    abstract::We compared the anti-estrogen receptors (ER) SP1, 6F11, and 1D5 antibodies in breast carcinoma cases with different ranges of positive cells to evaluate whether this could generate different therapies for patients. We selected 66 cases of breast cancer, each of which was immunostained with the 3 antibodies. 1D5 was le...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPLX0QJROV2IJG

    authors: Bogina G,Zamboni G,Sapino A,Bortesi L,Marconi M,Lunardi G,Coati F,Massocco A,Molinaro L,Pegoraro C,Venturini M

    更新日期:2012-11-01 00:00:00

  • Rapid detection of Klebsiella pneumoniae carbapenemase genes in enterobacteriaceae directly from blood culture bottles by real-time PCR.

    abstract::Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae are endemic in New York City hospitals and have been associated with serious infections globally. A real-time polymerase chain reaction (RT-PCR) assay was developed to detect carbapenem resistance attributable to KPC from blood culture bottles posi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP9SNHJG2QGLWU

    authors: Francis RO,Wu F,Della-Latta P,Shi J,Whittier S

    更新日期:2012-04-01 00:00:00

  • pH, PCO2 and PO2 in "high-volume" platelet concentrates prepared by discontinuous-flow centrifugation and stored in polyvinylchloride and plyethylene containers.

    abstract::High-volume (200 ml) platelet concentrates prepared by discontinuous-flow centrifugation, with counts as high as ca. 2.0 x 10(12)/l, were stored in either 600 ml-capacity polyvinylchloride bags or 800-ml capacity polyethylene bags. Both polyvinylchloride and polyethylene bags appeared adequate for 24-hour storage of p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.397

    authors: Rosenstein R,Lawe JE,North JG

    更新日期:1980-03-01 00:00:00

  • Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay.

    abstract:OBJECTIVES:Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. METHODS:We investigated the effects of edoxaban on prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin gene...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQ2NJD3PXFTUG

    authors: Morishima Y,Kamisato C

    更新日期:2015-02-01 00:00:00

  • Protein C assay performance: an analysis of North American specialized coagulation laboratory association proficiency testing results.

    abstract::To determine the performance and frequency of protein C reagents currently used by clinical laboratories, we analyzed North American Specialized Coagulation Laboratory Association (NASCOLA) protein C proficiency testing data from 6 surveys conducted in 2009 and 2010 (2009-1 to 2009-3 and 2010-1 to 2010-3). Interlabora...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP8MWU4QSTCLPU

    authors: Baron JM,Johnson SM,Ledford-Kraemer MR,Hayward CP,Meijer P,Van Cott EM

    更新日期:2012-06-01 00:00:00

  • erbB-2 oncoprotein expression in breast carcinoma. Poor prognosis associated with high degree of cytoplasmic positivity using CB-11 antibody.

    abstract::The relationship between immunohistochemically measured membranous expression of erbB-2 oncoprotein and prognosis in breast cancer is controversial, and the relationship between cytoplasmic positivity and prognosis has been minimally investigated. The clinical course of 300 women with infiltrating breast carcinoma, wh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.4.456

    authors: Keshgegian AA,Cnaan A

    更新日期:1997-10-01 00:00:00

  • Infusible platelet membranes retain partial functionality of the platelet GPIb/IX/V receptor complex.

    abstract::Infusible platelet membranes (IPMs) prepared from fresh or outdated human platelets have been shown to correct prolonged bleeding times in thrombocytopenic rabbits. In previous trials, IPMs did not seem to be immunogenic and lacked dose-limiting toxicity. The present study was undertaken to explore whether the platele...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/CCDV-3BEP-XXKP-BKDM

    authors: Graham SS,Gonchoroff NJ,Miller JL

    更新日期:2001-01-01 00:00:00

  • A comparative marker study of large cell lymphoma, Hodgkin's disease, and true histiocytic lymphoma in paraffin-embedded tissue.

    abstract::A comparative study of large cell lymphoma (LCL) (ten B and ten T), Hodgkin's disease (15 cases), and true histiocytic lymphoma (two cases) was undertaken, using formalin-fixed paraffin-embedded tissue sections, a panel of eight antibodies, and one lectin to determine if any particular antibody or immunologic profile ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.5.591

    authors: Meis JM,Osborne BM,Butler JJ

    更新日期:1986-11-01 00:00:00

  • The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas.

    abstract::Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPF4O0ADKFMGRJ

    authors: Ross DS,Liu YF,Pipa J,Shin SJ

    更新日期:2013-01-01 00:00:00

  • Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.

    abstract:Objectives:Early and accurate diagnosis remains crucial in the therapeutic management of invasive central nervous system fungal infections. Different molds have intrinsic resistance to antifungal agents; thus, morphologic differentiation is helpful to clinicians. Methods:Using three examples, we present a guide on how...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/aqx144

    authors: Chavez JA,Brat DJ,Hunter SB,Velazquez Vega J,Guarner J

    更新日期:2018-01-29 00:00:00

  • A clinician's workstation for improving laboratory use. Integrated display of laboratory results.

    abstract::Physicians are often forced to make decisions about the use of laboratory resources without adequate access to earlier results and related supporting information. Less than optimal use of the laboratory may result. The authors developed and deployed a clinical workstation meant to provide ready access to laboratory in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.3.243

    authors: Connelly DP,Sielaff BH,Willard KE

    更新日期:1995-09-01 00:00:00

  • Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis.

    abstract::Acute toxic hepatic necrosis is common and may be fatal. Predicting clinical outcome may be aided by following serum markers that could indicate recovery or may signify massive (substantial) destruction of functional liver mass. Previously, in a published case of chloroform poisoning, we serially assayed serum biomark...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/112.3.351

    authors: Horn KD,Wax P,Schneider SM,Martin TG,Nine JS,Moraca MA,Virji MA,Aronica PA,Rao KN

    更新日期:1999-09-01 00:00:00

  • Phenotype of the hairy cells of leukemic reticuloendotheliosis defined by monoclonal antibodies.

    abstract::Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.4.431

    authors: Janckila AJ,Stelzer GT,Wallace JH,Yam LT

    更新日期:1983-04-01 00:00:00

  • Cytologic/histologic correlation for quality control in cervicovaginal cytology. Experience with 1,582 paired cases.

    abstract::For quality-control purposes, federal regulations require cytology laboratories to compare Papanicolaou smear and cervical biopsy reports, if available, and determine the cause of any discrepancies. The authors reviewed 56,497 cervicovaginal smears, of which 1,582 (2.8%) had a subsequent cervical biopsy or endocervica...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.1.32

    authors: Joste NE,Crum CP,Cibas ES

    更新日期:1995-01-01 00:00:00

  • Thyroid Frozen Sections in Patients With Preoperative FNAs:  Review of Surgeons' Preoperative Rationale, Intraoperative Decisions, and Final Outcome.

    abstract:OBJECTIVES:We wished to discover (1) in what circumstances surgeons wished to request frozen sections (FSs) on thyroid nodules having a prior fine needle aspiration (FNA) and the preoperative plan in these cases; (2) what the surgeons did with the information provided by FS and (3) in what types of cases was value adde...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw042

    authors: Kennedy JM,Robinson RA

    更新日期:2016-05-01 00:00:00

  • Comparison of fluorescence and chromogenic in situ hybridization for detection of HER-2/neu oncogene in breast cancer.

    abstract::Determination of HER-2/neu oncogene amplification has become clinically important in the present management of breast cancer and may have important applications in other areas of clinical oncology and scientific research. In situ hybridization is an extremely accurate and sensitive technique for assessing amplificatio...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/p40p2ead42pukdmg

    authors: Gupta D,Middleton LP,Whitaker MJ,Abrams J

    更新日期:2003-03-01 00:00:00

  • Inherited giant platelet disorders. Classification and literature review.

    abstract::Inherited giant platelet disorders are extremely rare. The aim of this article is to review the clinical and laboratory features of this heterogeneous group and to arrive at a working classification. We conducted our literature search using the National Library of Medicine database. A total of 12 clinical entities wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/FC4H-LM5V-VCW8-DNJU

    authors: Mhawech P,Saleem A

    更新日期:2000-02-01 00:00:00

  • A civilian case of fatal meningococcemia due to Neisseria meningitidis, group Y.

    abstract::The present report is that of a civilian episode of fatal, fulminant group Y meningococcemia in a previously healthy adolescent, who denied prior vaccination against group C meningococcus. The patient suffered abrupt onset of purpura, hypotension and cardiopulmonary arrest. A detailed clinical and pathologic report is...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.2.296

    authors: Bernad PG,Snyder DA,Levey M

    更新日期:1977-08-01 00:00:00

  • Neonatal Intensive Care Unit Quality Initiative:  Identifying Preanalytical Variables Contributing to Specimen Hemolysis and Measuring the Impact of Evidence-Based Practice Interventions.

    abstract:OBJECTIVES:Blood specimen hemolysis is a major cause of sample recollection in the neonatal intensive care unit. We aimed to reduce the hemolysis rate from 6.3% at baseline to less than 4% within the 9 months' duration of the study. METHODS:Intravenous infusion of lipid emulsion during sample collection, sample collec...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw086

    authors: Tolan NV,Kaleta EJ,Fang JL,Colby CE,Carey WA,Karon BS,Baumann NA

    更新日期:2016-07-01 00:00:00

  • Accurate Real-Time Diagnosis of Lymphoproliferative Disorders in Malawi Through Clinicopathologic Teleconferences:  A Model for Pathology Services in Sub-Saharan Africa.

    abstract:OBJECTIVES:The incidence of lymphoproliferative disorders (LPDs) is increasing in sub-Saharan Africa (SSA) due to population growth, aging, and human immunodeficiency virus (HIV). Despite significant burden, resources for diagnosis and treatment of LPDs are limited, with little infrastructure to deliver modern patholog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw118

    authors: Montgomery ND,Liomba NG,Kampani C,Krysiak R,Stanley CC,Tomoka T,Kamiza S,Dhungel BM,Gopal S,Fedoriw Y

    更新日期:2016-10-01 00:00:00

  • Acetaminophen overdose with fetal demise.

    abstract::A case of fetal demise and maternal recovery after acetaminophen overdose is presented, to our knowledge the first reported. Fetal liver and maternal serum concentrations indicate overdose to be the cause of fetal death. Maternal disseminated intravascular coagulation (DIC) may have been related to maternal acetaminop...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.2.240

    authors: Haibach H,Akhter JE,Muscato MS,Cary PL,Hoffmann MF

    更新日期:1984-08-01 00:00:00

  • Membranous glomerulonephritis associated with the Guillain-Barré syndrome.

    abstract::A 63-year-old white man had simultaneous onset of the Guillain-Barré syndrome and the nephrotic syndrome, three weeks after having an upper respiratory tract infection. Many granular casts were noticed in the urine sediment. Renal biopsy specimens showed early membranous glomerulonephritis and acute interstitial nephr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.4.563

    authors: Talamo TS,Borochovitz D

    更新日期:1982-10-01 00:00:00

  • Serum enzyme alterations in polymyositis. Possible pitfalls in diagnosis.

    abstract::We report serum enzyme patterns in three patients with polymyositis or dermatomyositis whose cases posed potential problems in distinguishing malignancy, hepatocellular damage, and myocardial infarction from myositis. The alanine aminotransferase showed five- to 16-fold elevations. The creatine kinase MB isoenzyme and...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.4.556

    authors: Morton BD 3rd,Statland BE

    更新日期:1980-04-01 00:00:00

  • Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. A morphometric, immunohistochemical, and ultrastructural study.

    abstract::A morphometric and immunohistochemical study was performed to assess the spleen's alterations in patients with autoimmune thrombocytopenia and in drug abusers with thrombocytopenia (DAT) related to human immunodeficiency virus (HIV) infection. A total of 34 patients were included in the study: 20 DAT patients and 14 w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.6.633

    authors: Marti M,Feliu E,Campo E,Palacin A,Berga L,Casals FJ,Urbano Ispizua A,Cardesa A,Rozman C

    更新日期:1993-12-01 00:00:00

  • Expression of messenger RNA of the cardiac isoforms of troponin T and I in myopathic skeletal muscle.

    abstract::In the absence of clinical signs, elevated values of the cardiac isoforms of troponin T (cTnT) and I (cTnI) can be found in the serum samples of some patients with skeletal muscle myopathies; the cause is unclear. We studied the messenger RNA (mRNA) expression of cTnT and cTnI in the skeletal muscles of 24 patients wi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Messner B,Baum H,Fischer P,Quasthoff S,Neumeier D

    更新日期:2000-10-01 00:00:00

  • Vernix caseosa peritonitis. An infrequent complication of cesarean section with distinctive histopathologic features.

    abstract::The authors report two cases of vernix caseosa peritonitis, an infrequent complication of cesarean section with distinctive histopathologic findings. Both patients underwent exploratory laparotomy for unexplained abdominal pain after cesarean section. Histopathologic evaluation of surgically removed tissue revealed an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.6.681

    authors: George E,Leyser S,Zimmer HL,Simonowitz DA,Agress RL,Nordin DD

    更新日期:1995-06-01 00:00:00

  • Posttransplantation lymphoproliferative disorders in bone marrow transplant recipients are aggressive diseases with a high incidence of adverse histologic and immunobiologic features.

    abstract::Posttransplantation lymphoproliferative disorders (PT-LPDs) occurring in T-cell depleted (TCD) allogeneic bone marrow transplant recipients seem to be different from those that arise in solid organ recipients in their early development, the high incidence of extensive dissemination at presentation, and their aggressiv...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.4.419

    authors: Orazi A,Hromas RA,Neiman RS,Greiner TC,Lee CH,Rubin L,Haskins S,Heerema NA,Gharpure V,Abonour R,Srour EF,Cornetta K

    更新日期:1997-04-01 00:00:00

  • Apolipoprotein A-I-derived amyloid in atherosclerosis. Its association with plasma levels of apolipoprotein A-I and cholesterol.

    abstract::Wild-type apolipoprotein A-I (apo A-I)-derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reco...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/PJE6-X9E5-LX6K-NELY

    authors: Mucchiano GI,Jonasson L,Häggqvist B,Einarsson E,Westermark P

    更新日期:2001-02-01 00:00:00