Phenotype of the hairy cells of leukemic reticuloendotheliosis defined by monoclonal antibodies.

Abstract:

:Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg and antigens reactive with OKIa-1 and OKM-1 antibodies; these markers often were expressed simultaneously. T-cell-specific antigens were not displayed on the surface of hairy cells. The simultaneous expression of SIg and OKM-1 which ordinarily are unique for B cells or myeloid cells, respectively, suggests that hairy cells may represent an aberrant form of either cell type with defective regulation of antigen expression. It alternatively suggests the possibility that B cells and myeloid elements develop along a common pathway and that the hairy cell is a component of such a pathway.

journal_name

Am J Clin Pathol

authors

Janckila AJ,Stelzer GT,Wallace JH,Yam LT

doi

10.1093/ajcp/79.4.431

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

431-7

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

79

pub_type

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