American Burkitt's lymphoma-hand-mirror variant. A detailed investigation of cytologic, ultrastructural, and immunologic features.

Abstract:

:Previous studies of patients with lymphoid malignancies have suggested a relationship between survival and the presence of more than 40% hard-mirror cells in the bone marrow. This report represents the first detailed study of a patient with American Burkitt's lymphoma with numerous hand-mirror cells in the bone marrow during the course of the disease. The Burkitt cells were atypical because of their hand-mirror configuration in the bone marrow, the presence of cytoplasmic glycogen, the finding of an IgG surface marker, and a strongly positive acid phosphatase staining reaction. The presence of increased numbers of hand-mirror forms in the bone marrow during the course of the patient's illness may have clinical significance, because they were replaced by non-hand-mirror Burkitt cells in the terminal phase. More reports and investigations of patients with large numbers of hand-mirror forms in the bone marrow are needed to elucidate the full significance of this unusual cellular phenomenon.

journal_name

Am J Clin Pathol

authors

Schumacher HR,Rainey T,Davidson L,Simon D,Strong M,Creegan WJ,Holloway ML,Stass SA

doi

10.1093/ajcp/70.6.937

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

937-44

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

70

pub_type

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