Radioimmunoassays for protein C and factor X. Plasma antigen levels in abnormal hemostatic states.

Abstract:

:Specific radioimmunoassays, sensitive to plasma levels of less than 1% of normal, were developed for protein C and Factor X. In 31 normal subjects, mean plasma antigen levels were as follows: protein C, 3.23 +/- 0.79 microgram/mL (2 SD); Factor X, 7.74 +/- 1.81 microgram/mL. In patient son chronic warfarin therapy, protein C and factor X were depressed equivalently: protein C, 42% +/- 20% (of a pooled plasma reference); Factor X, 44% +/- 24%. Protein C antigen fell much more rapidly than Factor X antigen when warfarin therapy was begun, creating an initial period of potential hypercoagulability. In patients with severe liver disease, mean protein C antigen (25% +/- 17%) was lower than Factor X antigen (51% +/- 29%). Protein C antigen levels did not appear to be a sensitive indicator of compensated intravascular coagulation or systemic fibrinolysis induced by infusion of streptokinase. Clinical implications of these findings are discussed.

journal_name

Am J Clin Pathol

authors

Epstein DJ,Bergum PW,Bajaj SP,Rapaport SI

doi

10.1093/ajcp/82.5.573

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

573-81

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

82

pub_type

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