Pathology consultation on the laboratory evaluation of thrombophilia: when, how, and why.

Abstract:

:Venous thromboembolism (VTE) results from the interaction of the Virchow triad (venous stasis, endothelial injury, and hypercoagulability). Risk factors for increased hypercoagulability, or thrombophilia, include activated protein C resistance/factor V Leiden, the prothrombin G20210A mutation, deficiencies of the natural anticoagulants (antithrombin, proteins C and S), antiphospholipid antibodies, hyperhomocysteinemia, and increased factor VIII activity. Not all patients with VTE need to be tested for such risk factors, but patients with thrombophilia should be evaluated for all possibilities to better estimate risk. At the same time, testing should be patient-specific because assay results are affected by preanalytic variables, including thrombosis and anticoagulant therapy.

journal_name

Am J Clin Pathol

authors

Ballard RB,Marques MB,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.

doi

10.1309/AJCP5SQT3ZKYQFBM

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

553-60

issue

4

eissn

0002-9173

issn

1943-7722

pii

137/4/553

journal_volume

137

pub_type

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