Comparison of the sensitivity of commercial APTT reagents in the detection of mild coagulopathies.

Abstract:

:This study was undertaken to evaluate the precision and sensitivity of three different commercial APTT reagents containing the activators kaolin, micronized silica, or ellagic acid. These reagents varied greatly in their ability to detect mild coagulopathies. The ellagic acid reagent was able to detect the mildest deficiencies for the most common coagulopathies. This reagent was sensitive to 50% levels of Factor VIIIC, whereas the APTT with the kaolin reagent was not prolonged until levels of 35% or less were attained. The micronized silica reagent was the least sensitive to Factor IX deficiency, detecting levels of 12% or less. Precision was similar for all reagents when tested with normal and slightly abnormal plasmas. Since methods and instrumentation vary, each laboratory should evaluate their APTT reagent to determine its precision and sensitivity.

journal_name

Am J Clin Pathol

authors

Marlar RA,Bauer PJ,Endres-Brooks JL,Montgomery RR,Miller CM,Schanen MM

doi

10.1093/ajcp/82.4.436

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

436-9

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

82

pub_type

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