Detection of allergic disease in adenoid tissue.

Abstract:

:Allergic adenoiditis is defined as the presence of numerous brightly fluorescent IgE mast cells (FIEMC) demonstrated in formalin-fixed adenoid tissue by the trypsin-immunofluorescent method. A prospective study of 606 routinely accessioned cases seen during a 39-month period revealed 98 positive cases. Correlation with clinical and other allergic diagnostic testing revealed a sensitivity of 58% and a specificity of 89%. The pathogenetic role of allergy in chronic otitis media with effusion appears to be related to an exaggerated immediate hypersensitivity response to an allergen and/or infectious agent leading to dysfunction of the eustachian tube. The proximity and shared mucosa of adenoid tissue and eustachian tube allow the recognition of this inflammatory event.

journal_name

Am J Clin Pathol

authors

Loesel LS

doi

10.1093/ajcp/81.2.170

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

170-5

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

81

pub_type

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