Abstract:
:An American black family in whom hemoglobin J Baltimore and beta (+)-thalassemia genes coexisted is described. The proposita is a 23-year-old woman with a hemoglobin (Hb) level of 11.5 g/dl, microcytic, hypochromic indices, increased values of Hbs A2 and F, and alpha/non-alpha synthetic ratio of 1.52. Hbs A and J Baltimore (beta 16 Gly---Asp) constituted 12% and 81.3%, respectively, of her total hemoglobin. Her sister had a very similar peripheral blood picture, but Hbs A and J Baltimore constituted 6.8% and 85.5%, respectively, of her total hemoglobin, and the alpha/non-alpha synthetic ratio was 1.39. The mother had beta(+)-thalassemia trait only, a moderate degree of anemia, and greater synthetic imbalance (alpha/non-alpha raio of 1.73). These findings suggest that the presence of the Hb J Baltimore gene ameliorates the effects of a coexistent beta-thalassemia gene.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Ballas SK,Atwater J,Theriault C,Kim HC,Propst Mdoi
10.1093/ajcp/75.6.843subject
Has Abstractpub_date
1981-06-01 00:00:00pages
843-6issue
6eissn
0002-9173issn
1943-7722journal_volume
75pub_type
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journal_title:American journal of clinical pathology
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