Mesothelin expression in pancreatic mucinous cysts.

Abstract:

OBJECTIVES:Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. METHODS:From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was performed on representative sections. RESULTS:MSLN was seen more frequently in neoplastic epithelial cells from IPMN (39/52; P < .0005) and MCN (9/14; P < .0001) compared with unremarkable adjacent pancreatic and bile ducts (0/57) and benign foveolar and duodenal epithelium (0/21). When present, MSLN was diffusely expressed in neoplastic epithelium and only focally expressed in adjacent ducts (8/57). No significant difference was seen (P = .26) in MLSN expression between IPMN (79%) and MCN (83%) when only presence or absence was considered. CONCLUSION:Our findings suggest that MLSN can be used as a marker of neoplastic transformation of epithelial cells in pancreatic mucinous cysts. The findings can help identify neoplastic mucinous epithelium.

journal_name

Am J Clin Pathol

authors

Frank R,Li S,Ahmad NA,Sepulveda AR,Jhala NC

doi

10.1309/AJCPDTTL2I5ECMFG

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

313-9

issue

3

eissn

0002-9173

issn

1943-7722

pii

142/3/313

journal_volume

142

pub_type

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