Immunohistochemical identification of lysozyme in cutaneous lesions of alleged histiocytic nature.

Abstract:

:Histiocytosis X, multicentric reticulohistiocytosis, juvenile xanthogranuloma, the "fibrous" type of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma are all characterized by dermal and/or subcutaneous infiltrates composed at least partially of cells having morphologic features suggestive of histiocytes. Paraffin-embedded tissues representing these conditions were stained for lysozyme (muramidase) with a peroxidase-antiperoxidase technic. The cells of juvenile xanthogranuloma were rich in lysozyme. Some of the cells of histiocytosis X showed a positive pattern, and the cells of the other three conditions were essentially negative. This study confirmed the histiocytic nature of juvenile xanthogranuloma and multicentric reticulohistiocytosis, supported the interpretation that there is a histiocytic component in the lesions of histiocytosis X, and cast some doubt on the alleged histiocytic nature of "fibrous" dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma.

journal_name

Am J Clin Pathol

authors

Burgdorf WH,Duray P,Rosai J

doi

10.1093/ajcp/75.2.162

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

162-7

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

75

pub_type

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