Hepatic oncocytes. Incidence, staining characteristics, and ultrastructural features.

Abstract:

:Hepatocytes with orcein-positive ground-glass cytoplasm have been shown to contain abundant hepatitis B surface antigen in the cisternae of excess smooth endoplasmic reticulum. Hepatocytes with similar cytoplasmic changes that did not react with orcein were observed in 26.5% of 49 cases of cirrhosis. These cells exhibited granular, deeply eosinophilic cytoplasm that stained with phosphotungstic acid-hematoxylin and contained numerous densely packed mitochondria as demonstrated by electron microscopy. Therefore, these cells were designated hepatic oncocytes. They were detected predominantly in cases of established cirrhosis, unrelated to etiology. Hepatic oncocytes may form nodular aggregates, but they did not show evidence of regeneration. The nature and pathogenesis of these cells remain unclear. Because of similar appearance, histochemical stains may be necessary to distinguish ground-glass hepatocytes from hepatic oncocytes.

journal_name

Am J Clin Pathol

authors

Gerber MA,Thung SN

doi

10.1093/ajcp/75.4.498

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

498-503

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

75

pub_type

杂志文章
  • Histopathologic and molecular profile of human cytomegalovirus infections in patients with heart transplants.

    abstract::From November 1985 to December 1990, 2,552 endomyocardial biopsy specimens from 209 heart transplant patients were studied. Forty-four (21%) patients developed 45 episodes of major human cytomegalovirus infection (HCMV). Human cytomegalovirus infection was primary in 13 of 44 patients. Thirty-one patients developed ep...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Arbustini E,Grasso M,Diegoli M,Percivalle E,Grossi P,Bramerio M,Campana C,Goggi C,Gavazzi A,Vigano M

    更新日期:1992-08-01 00:00:00

  • A Venn diagram model that allows triple-label immunophenotypic analysis of cells based upon double-label measurements.

    abstract::Using Venn diagrams derived from set theory, a mathematic model is presented that allows triple-label immunophenotypic analysis of cells based upon double-label measurements. Practical applications of this method are illustrated and discussed. Using this model, triple-label data concerning Leu-8 and Leu-9 (CD7) antige...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.1.73

    authors: Wood GS

    更新日期:1989-07-01 00:00:00

  • Cold agglutinin disease after chicken pox. An uncommon complication of a common disease.

    abstract::Chicken pox, although common, is rarely associated with autoimmune hemolytic anemia. Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox. The cold agglutinin appeared to be a polyclonal immunoglobulin M antibody wit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.1.92

    authors: Friedman HD,Dracker RA

    更新日期:1992-01-01 00:00:00

  • Lipocortin-1 immunoreactivity in the normal human central nervous system and lesions with astrocytosis.

    abstract::The authors have examined the cellular distribution of lipocortin-1 (L-1) in the normal and diseased central nervous system (CNS) using the peroxidase-antiperoxidase (PAP) technique with a polyclonal antibody specific for L-1. L-1 immunoreactivity was evaluated in the frontal cortex, parahippocampal gyrus/lateral vent...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.4.424

    authors: Johnson MD,Kamso-Pratt JM,Whetsell WO Jr,Pepinsky RB

    更新日期:1989-10-01 00:00:00

  • Multifocal Extraprostatic Extension of Prostate Cancer.

    abstract:OBJECTIVES:To investigate the prognostic utility of multifocal extraprostatic extension (EPE) on biochemical recurrence after radical prostatectomy. METHODS:We conducted retrospective analysis of biochemical recurrence and prognostic pathologic variables in 673 men with stage pT3a/pT3b prostate cancer from 2000 to 201...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz193

    authors: Farchoukh L,Laframboise WA,Nelson JB,Bastacky S,Parwani AV,Dhir R

    更新日期:2020-03-09 00:00:00

  • Squamous metaplasia of the prostate. An immunohistochemical study.

    abstract::Immunoperoxidase strains for prostate-specific antigen (PSA), prostatic acid phosphatase (PAcP), epithelial membrane antigen (EMA), and cytokeratins (MAK 6 and CK-KES) were performed on 1 case of squamous cell carcinoma of the prostate and on 13 cases of squamous metaplasia of prostatic epithelium in an effort to demo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.5.597

    authors: Lager DJ,Goeken JA,Kemp JD,Robinson RA

    更新日期:1988-11-01 00:00:00

  • Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54.

    abstract::Two hundred forty-three patients who had pathologically verified primary osteosarcomas of bone, treated at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute over a 24-year period, form the basis of this study. These cases provide a basis for comparison of those patients currentl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.5.427

    authors: Uribe-Botero G,Russell WO,Sutow WW,Martin RG

    更新日期:1977-05-01 00:00:00

  • Measuring errors in surgical pathology in real-life practice: defining what does and does not matter.

    abstract::This review summarizes our experience using blinded review as a method to measure quality in surgical pathology. It details the specifics about how the review is performed, the weaknesses in the method, and then summarizes our results so far. These results suggest that error rates correlate with the individual patholo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/5KF89P63F4F6EUHB

    authors: Renshaw AA,Gould EW

    更新日期:2007-01-01 00:00:00

  • Cellular dyscohesion in fine-needle aspiration of breast carcinoma. Prognostic indicator for axillary lymph node metastases?

    abstract::The role of fine-needle aspiration (FNA) in the diagnosis of breast carcinoma is established. We evaluated whether the degree of cellular dyscohesion and the nuclear grade in FNA material of breast carcinomas are reliable prognostic predictors for ipsilateral axillary lymph node metastasis. FNA specimens from 98 women...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/PR6K-7RXQ-NJUD-443Q

    authors: Schiller AB,Tadros TS,Birdsong GG,Grossl NA

    更新日期:2001-02-01 00:00:00

  • Recombinant protein to analyze autoantibodies to proteinase 3 in systemic vasculitis.

    abstract::The presence of antineutrophil cytoplasmic autoantibodies with specificity for proteinase 3 (PR3-ANCA) usually is detected by enzyme-linked immunosorbent assay (ELISA) with purified PR3 as a substrate. We studied the technical performance of direct and capture ELISA using a recombinant proteolytically inactive form of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/YTU2-FUHB-EXJL-WMLD

    authors: Rarok AA,Huitema MG,van der Leij MJ,van der Geld YM,Berthold H,Schmitt J,Stegeman CA,Limburg PC,Kallenberg CG

    更新日期:2003-10-01 00:00:00

  • Peliosis of the spleen.

    abstract::Peliosis of the spleen was found in 10 out of 1,200 cases autopsied from 1977 through 1980 in our laboratory. Eight such cases had no peliosis of the liver. Histologically, it was noticed that the parafollicular areas were the most common sites of the lesions, and this feature seemed to be important for the histologic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.6.708

    authors: Tada T,Wakabayashi T,Kishimoto H

    更新日期:1983-06-01 00:00:00

  • Kallikrein inhibition and C1-esterase inhibitor levels in patients with the lupus inhibitor.

    abstract::It has been suggested that kallikrein inhibition may predispose patients with the lupus inhibitor to thrombosis by interfering with the Factor XII-mediated activation of plasminogen. To further investigate this suggestion, the authors measured kallikrein inhibition in 19 patients with the lupus inhibitor. They found t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.2.223

    authors: Killeen AA,Meyer KC,Vogt JM,Edson JR

    更新日期:1987-08-01 00:00:00

  • Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers.

    abstract::An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.1.1

    authors: Bergh J,Esscher T,Steinholtz L,Nilsson K,Påhlman S

    更新日期:1985-07-01 00:00:00

  • Detection of cytomegalovirus antibodies in serum using the TranSTAT-CMV and CMV Scan assays.

    abstract::Two hundred serum samples were tested with two assays for rapid detection of cytomegalovirus (CMV) antibodies. The assays were CMV Scan, a two-step latex particle agglutination assay for CMV IgG and IgM antibodies, and TranSTAT-CMV, a newly available six-step solid-phase enzyme immunoassay for CMV IgG antibodies. Comp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.5.539

    authors: Roseff SD,Campos JM

    更新日期:1993-05-01 00:00:00

  • An immunohistologic study of the feto-acinar pancreatic protein (FAP) in the normal pancreas, chronic pancreatitis, pancreatic adenocarcinoma, and intraabdominal metastases of adenocarcinomas.

    abstract::The immunohistologic distribution of the feto-acinar pancreatic protein (FAP), detected by the monoclonal antibody (MoAb) J28 using an indirect immunoperoxidase technique, is described. Tests were carried out on normal adult pancreas (n = 10), chronic pancreatitis (n = 14), pancreatic adenocarcinoma (n = 17), intraabd...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.1.14

    authors: Albers GH,Escribano MJ,Daher N,Nap M

    更新日期:1990-01-01 00:00:00

  • Quantitative measurement of HbA1c by an immunoturbidimetric assay compared to a standard HPLC method.

    abstract::Determination of hemoglobin A1c (HbA1c) is one of the most important monitoring procedures for long-term control of diabetes mellitus. Several analytical methods have been developed for the measurement of glycohemoglobin (GHb). Those most frequently used are ion-exchange chromatography for HbA1c and affinity chromatog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.1.89

    authors: Hamwi A,Schweiger CR,Veitl M,Schmid R

    更新日期:1995-07-01 00:00:00

  • Speciation of the "viridans" streptococci.

    abstract::A simple scheme for the speciation of clinical isolates of "viridans" streptococci based on nine physiological characteristics is presented. Use of this scheme will enable successful speciation of most "viridans" strep isolates in any laboratory and allow for the accumulation of data necessary for the definition of cl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.1.78

    authors: Sands M,Sommers HM,Rubin MB

    更新日期:1982-07-01 00:00:00

  • Racial differences in vitamin B12 levels in the United States.

    abstract::Studies from Africa have demonstrated that black people have higher vitamin B12 (cobalamin) levels than do white people. The authors compared healthy white people, black people, and Latin-Americans in the United States. Their study is also the largest in which the effect of race and sex on the cobalamin levels has bee...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.95

    authors: Saxena S,Carmel R

    更新日期:1987-07-01 00:00:00

  • Promyelocytic blast crisis of chronic myelogenous leukemia. A rare subtype associated with disseminated intravascular coagulation.

    abstract::Two patients with chronic myelogenous leukemia (CML) developed blast crisis that morphologically appeared to be the microgranular variant of acute promyelocytic leukemia. This represented 8% of CML patients developing blast crisis from 1984 to 1993. Cytogenetic studies revealed translocation 15;17 in addition to trans...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.2.185

    authors: Rosenthal NS,Knapp D,Farhi DC

    更新日期:1995-02-01 00:00:00

  • Analysis of cerebrospinal fluid cells from an american child with Burkitt's Lymphoma.

    abstract::Tumor cells in the cerebrospinal fluid of an American child with Burkitt's lymphoma are described. The morphology of the cells was demonstrated better by use of the "millipore" technic and hematoxylin and eosin staining than by the Wright-stained smear. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.2.238

    authors: Fuchs HB,Rosan RC

    更新日期:1975-08-01 00:00:00

  • Spectrophotometric detection of RT-PCR-amplified BCR/ABL fusion transcripts. A survey performed on archival hematologic slides.

    abstract::We describe a method of spectrophotometric detection of BCR/ABL chimeric sequences amplified by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), enabling the use of archival hematologic slides as RNA sources. Multiplex PCR amplified b3a2, b2a2, and e1a2 break points of the BCR/ABL translocation and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.4.383

    authors: Attadia V,Alosi M,Improta S,Zagonel V,Martinazzo G,Carbone A,Pinto A

    更新日期:1997-10-01 00:00:00

  • Instability of immunophenotype in plasma cell myeloma.

    abstract::Little information has been reported describing antigen stability in plasma cell myeloma. In this study, the expression frequency and stability of 2 potential therapeutic targets, CD20 and CD52, along with the frequently aberrantly expressed CD56 antigen, were evaluated by flow cytometric analyses in 56 patients with ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/8UVF7YQ1D4D4ETQV

    authors: Cao W,Goolsby CL,Nelson BP,Singhal S,Mehta J,Peterson LC

    更新日期:2008-06-01 00:00:00

  • High-density lipoprotein cholesterol. Significant bias between methods.

    abstract::Cholesterol content of the high-density lipoproteins has become of interest in evaluating the risk of development of coronary heart disease. There is an inverse relationship between high-density lipoprotein cholesterol and risk. The authors found a significant bias (11.1 mg/dl; 0.289 mmol/l) in a comparison of a rapid...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.5.564

    authors: Gerson B,Dean L,Copeland BE

    更新日期:1979-05-01 00:00:00

  • Trapped plasma in the microhematocrit.

    abstract::The amount of trapped plasma in the microhematocrit red blood cell column of samples from 25 normal individuals and 102 patients was investigated. The mean value for the normal individuals was 1.53%, and the mean values for the samples from the patient groups ranged from 1.41% to 1.82%. These groups included patients ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.5.770

    authors: Pearson TC,Guthrie DL

    更新日期:1982-11-01 00:00:00

  • Immunophenotypic profile of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.

    abstract::We retrospectively reviewed the immunophenotypic profile of 75 cases of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) analyzed by flow cytometry. All patients had monoclonal IgM (median, 2,100 mg/dL [21 g/L]) in serum and were considered clinically to have WM. The neoplastic cells, in all cases, ex...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3G1X-DX0D-VHBN-VKB4

    authors: Konoplev S,Medeiros LJ,Bueso-Ramos CE,Jorgensen JL,Lin P

    更新日期:2005-09-01 00:00:00

  • Paucicellular variant of anaplastic thyroid carcinoma. A mimic of Reidel's thyroiditis.

    abstract::Anaplastic thyroid carcinomas usually pose no problems in histologic diagnosis because of the obvious invasive growth, high cellularity, and frank anaplasia. Two cases of a variant of anaplastic thyroid carcinoma with peculiar gross and histologic features closely mimicking those of Riedel's thyroiditis are described ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.4.388

    authors: Wan SK,Chan JK,Tang SK

    更新日期:1996-04-01 00:00:00

  • Ultrastructure of the gastric mucosa harboring Campylobacter-like organisms.

    abstract::The association between Campylobacter-like organisms (CLOs) and lesions of the gastric mucosa was studied in 59 consecutive biopsies. Hematoxylin and eosin and Warthin-Starry silver stains, as well as high-resolution light microscopy (HRLM) and transmission electron microscopy (TEM), were used. The organisms were foun...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.5.575

    authors: Chen XG,Correa P,Offerhaus J,Rodriguez E,Janney F,Hoffmann E,Fox J,Hunter F,Diavolitsis S

    更新日期:1986-11-01 00:00:00

  • GATA3 expression in advanced breast cancer: prognostic value and organ-specific relapse.

    abstract:OBJECTIVES:GATA3 is a transcription factor regulating luminal cell differentiation in the mammary glands and has been implicated in the luminal types of breast carcinoma. The prognostic significance of GATA3 in breast cancer remains controversial. METHODS:In this study, we assessed the prognostic value of the molecule...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP5MMR1FJVVTPK

    authors: McCleskey BC,Penedo TL,Zhang K,Hameed O,Siegal GP,Wei S

    更新日期:2015-11-01 00:00:00

  • Can We Identify Nephrogenic Adenoma in Urine Cytology Specimens? A Study Evaluating Previously Described Cytomorphologic Features in Correlation With PAX8 Immunohistochemical Staining Results.

    abstract:OBJECTIVES:The aim of this study is to determine if the diagnosis of nephrogenic adenoma (NA) can be made on cytologic criteria alone and if pair box gene transcription factor 8 (PAX8) is useful in the diagnosis of NA in daily cytology practice. METHODS:Cytologic features of NA previously described in a literature wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw006

    authors: McCroskey Z,Pambuccian SE,Wojcik EM,Barkan GA

    更新日期:2016-03-01 00:00:00

  • Tumor-Infiltrating Lymphocytes in Breast Cancer: Evaluating Interobserver Variability, Heterogeneity, and Fidelity of Scoring Core Biopsies.

    abstract:Objectives:The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB). Methods:Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy069

    authors: Khoury T,Peng X,Yan L,Wang D,Nagrale V

    更新日期:2018-10-01 00:00:00