Abstract:
OBJECTIVES:The aim of this study is to determine if the diagnosis of nephrogenic adenoma (NA) can be made on cytologic criteria alone and if pair box gene transcription factor 8 (PAX8) is useful in the diagnosis of NA in daily cytology practice. METHODS:Cytologic features of NA previously described in a literature were used to identify NA cells in urinary specimens. Subsequently, all cytology and corresponding biopsy specimens were stained with the PAX8 immunohistochemistry stain. The stains were examined; the results were tabulated. RESULTS:A total of 44 specimens were reviewed (35 with corresponding biopsy specimens diagnosed as NA and nine negative for NA diagnosis on corresponding biopsy specimens). Of them, 14 demonstrated features previously described as NA. None of atypical cells that were morphologically suspicious for NA showed positive staining, whereas all of the corresponding biopsy sections demonstrated nuclear PAX8 positivity. Only rare lymphocytes present in cytology specimens showed nuclear staining with PAX8. CONCLUSIONS:Assuming that the results of the PAX8 stain performed are accurate at least in most cases, as suggested by the presence of internal positive controls, our study shows that the previously described cytologic features of NA cannot be used as diagnostic criteria, since they are not characteristic for this entity.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
McCroskey Z,Pambuccian SE,Wojcik EM,Barkan GAdoi
10.1093/ajcp/aqw006subject
Has Abstractpub_date
2016-03-01 00:00:00pages
373-8issue
3eissn
0002-9173issn
1943-7722pii
aqw006journal_volume
145pub_type
杂志文章abstract::Three stillborn fetuses are reported in which an abdominal wall defect was associated with defects in the urogenital and anal region. Autopsy of these fetuses provided clues indicative of how and where the embryonic development went wrong. The malformation involved a disturbance of the cell deposition process, occurri...
journal_title:American journal of clinical pathology
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更新日期:1991-11-01 00:00:00
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abstract::Borrelia burgdorferi is difficult to detect in routine biopsy material from patients with skin lesions of borreliosis. In this study, a new immunohistochemical method, focus floating microscopy (FFM), was developed to detect B burgdorferi in tissue sections and was compared with polymerase chain reaction (PCR). By usi...
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更新日期:1978-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1975-08-01 00:00:00
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更新日期:2000-07-01 00:00:00
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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更新日期:1986-10-01 00:00:00
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更新日期:1982-06-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:1982-07-01 00:00:00
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更新日期:1980-02-01 00:00:00
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更新日期:1988-04-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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更新日期:1982-03-01 00:00:00