Abstract:
:Anti-glomerular basement membrane (anti-GBM) glomerulonephritis is a rare disease caused by IgG autoantibodies against the glomerular basement membrane. We describe clinical and pathologic findings in a series of renal biopsy specimens from 80 patients. The patients ranged in age from 16 to 87 years. The age distribution was bimodal, with one peak at a young age predominated by males and a second peak in the sixth to eighth decades with females predominating. Most patients (70 [88%]) had severe necrotizing glomerulonephritis with crescents in more that 50% of glomeruli. The fraction of crescentic glomeruli in biopsy specimens correlated well with serum creatinine levels but not with serologic titers for anti-GBM antibodies. Interstitial fibrosis was uncommon and, when present, minimal to mild. Linear IgG deposition defines this entity, but immunofluorescent costaining for other immunoglobulins and complement is found frequently. To our knowledge, this is the largest series of renal biopsy specimens with anti-GBM glomerulonephritis studied to date.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Fischer EG,Lager DJdoi
10.1309/nptp-4ukv-7ju3-elmqsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
445-50issue
3eissn
0002-9173issn
1943-7722journal_volume
125pub_type
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pub_type: 杂志文章
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更新日期:2020-10-13 00:00:00