An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease.

Abstract:

:In view of their reported reciprocal effects on apoptosis, the expression of p53 and bcl-2 proteins was studied in 46 cases of Hodgkin's disease by immunocytochemical labeling. We found p53 protein in Reed-Sternberg cells and their mononuclear variants in 16 of the 46 cases (34.7%) of Hodgkin's disease, mainly in a nuclear pattern. This restricted expression on Reed-Sternberg cells and variants supports their neoplastic nature. This overexpression of p53 protein in one third of Hodgkin's disease cases is similar to that seen in many other human malignancies. bcl-2 protein was present in mantle zone B cells and scattered T cells in all cases, and in 17 cases (37.7%) of Hodgkin's disease in Reed-Sternberg cells and their mononuclear variants. Six cases coexpressed both proteins, whereas in 18 cases neither was identified. There is no apparent relationship between p53 and bcl-2 protein expression, and on the basis of the present results there is no reason to suppose that they have any particular complementary effects on the neoplastic transformation in Hodgkin's disease.

journal_name

Am J Clin Pathol

authors

Doussis IA,Pezzella F,Lane DP,Gatter KC,Mason DY

doi

10.1093/ajcp/99.6.663

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

663-7

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

99

pub_type

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