当前位置： SCI文献检索 > AMERICAN JOURNAL OF CLINICAL PATHOLOGY期刊下所有文献 > Detection of immunophenotypic abnormalities in paraffin-embedded B-lineage non-Hodgkin's lymphomas.

Detection of immunophenotypic abnormalities in paraffin-embedded B-lineage non-Hodgkin's lymphomas.

Abstract：

:The authors analyzed the frequency of immunophenotypic abnormalities in 1,474 cases of routinely fixed, paraffin-embedded B-lineage non-Hodgkin's lymphomas. B-lineage was determined by immunoreactivity for CD20 (L26, 92%); CD45RA (4KB5, an additional 3%) or immunoglobulin (Ig) light chain restriction (remaining 5%). CD45RA was found to be especially helpful on Bouin's-fixed or decalcified tissue and Ig staining was most helpful in plasmacytoid lesions. Coexpression of the T-cell marker CD43 (Leu-22) was the most common immunophenotypic abnormality, seen in 60% of mantle cell lymphomas (MCL), 39% of CLL/small lymphocytic lymphomas, 16% of diffuse large cell lymphomas (DLCL), but only 5% of follicular lymphomas (FL). Antibodies to CD45RO (A6 and UCHL1) and CD3 (polyclonal) were useful in distinguishing infiltrating T cells from B cells coexpressing CD43. Ig light chain restriction was the next commonest immunophenotypic abnormality, which was identified in 67% of plasmacytoid diffuse small cell lymphomas, 43% of MCLs, 35% of monocytoid B-cell lymphomas and 28% of FLs. Overexpression of bcl-2 oncogenic protein was observed in 71% of FLs (n = 96), but not in a control group of reactive follicular hyperplasias (n = 34). Combining two criteria increased the sensitivity of immunodiagnosis in certain circumstances.

journal_name

Am J Clin Pathol

journal_title

American journal of clinical pathology

authors

Gelb AB,Rouse RV,Dorfman RF,Warnke RA

doi

10.1093/ajcp/102.6.825

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

825-34

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

102

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF CLINICAL PATHOLOGY文献大全
  • Single-dose tetracycline labeling for bone histomorphometry.

    abstract：:A single oral dose of tetracycline deposits in bone and is readily identified with fluorescence microscopy. Two such time-spaced labels can be used to determine bone dynamic features. This is as accurate as conventional three-day labeling periods. The simplicity, improved compliance, and substantial reduction in time ...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/91.6.682

    authors： Sherrard DJ,Maloney NA

    更新日期：1989-06-01 00:00:00

  • Restrictive Transfusion Strategy and Clinical Decision Support Practices for Reducing RBC Transfusion Overuse.

    abstract：OBJECTIVES:Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients. METHODS:Following the Centers for Disease Control and...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/aqz070

    authors： Derzon JH,Clarke N,Alford A,Gross I,Shander A,Thurer R

    更新日期：2019-10-07 00:00:00

  • The effects of heparin on lipoproteins in high-resolution electrophoresis of serum.

    abstract：:Sera from heparinized patients commonly display anodal slurring of both the alpha and beta lipoproteins when they are examined by high-resolution electrophoresis (HRE). In this study, the authors examined the effect of heparin and lipoprotein lipase on the electrophoretic migration of alpha and beta lipoproteins in se...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/104.4.468

    authors： Pearson JP,Keren DF

    更新日期：1995-10-01 00:00:00

  • Double immunostaining of lymph node sections by monoclonal antibodies using phycoerythrin labeling and haptenated reagents.

    abstract：:Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/82.1.44

    authors： Pizzolo G,Chilosi M

    更新日期：1984-07-01 00:00:00

  • Clinical and pathologic findings of the liver in the acquired immune deficiency syndrome (AIDS).

    abstract：:Clinical data and histologic sections of the liver, including immunohistochemical studies for hepatitis B surface and core antigens, were reviewed in 42 autopsy cases of the acquired immune deficiency syndrome (AIDS). Hepatomegaly, elevation of serum transaminases, and mild elevation of alkaline phosphatase were commo...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/83.5.582

    authors： Glasgow BJ,Anders K,Layfield LJ,Steinsapir KD,Gitnick GL,Lewin KJ

    更新日期：1985-05-01 00:00:00

  • Computerized interactive morphometry and the diagnosis of lymphoid-rich effusions.

    abstract：:An experimental computerized interactive morphometry system for the classification of lymphoid-rich effusions is presented. The relatively inexpensive microcomputer-based system was assembled in our laboratory with commercially available hardware and software. One hundred twenty-two effusions (86 benign lymphocytoses,...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/99.5.570

    authors： Walts AE,Morimoto R,Marchevsky AM

    更新日期：1993-05-01 00:00:00

  • Solar elastosis in cutaneous melanoma.

    abstract：:By studying more than 1,200 patients with cutaneous melanoma and long-term follow-up, I examined the relationship between solar elastosis and age at diagnosis of melanoma, key features of melanoma, and the outcome of overall survival in melanoma. I found that melanomas with elastosis were diagnosed significantly later...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/7MHX96XH3DTY32TQ

    authors： Vollmer RT

    更新日期：2007-08-01 00:00:00

  • Establishing Evidence-Based Statistical Quality Control Practices.

    abstract：OBJECTIVES:To establish an objective, scientific, evidence-based process for planning statistical quality control (SQC) procedures based on quality required for a test, precision and bias observed for a measurement procedure, probabilities of error detection and false rejection for different control rules and numbers o...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/aqy158

    authors： Westgard JO,Westgard SA

    更新日期：2019-03-01 00:00:00

  • Improving quality of patient care in an emergency department: a laboratory perspective.

    abstract：:The purpose of our study was to improve the quality of care in an emergency department (ED) as measured by length of stay (LOS), total turnaround time (TAT) for laboratory result reporting, and the blood culture contamination rate. Data were included for patients who had at least 1 of 5 laboratory tests performed as p...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/DGXYTH0VNTTQRQHD

    authors： Sheppard C,Franks N,Nolte F,Fantz C

    更新日期：2008-10-01 00:00:00

  • Giant lymph node hyperplasia of the hyaline vascular type with plasmacytoid T-cells and presentation in infancy.

    abstract：:Giant lymph node hyperplasia is uncommon in children and is exceptionally rare in infancy. The authors report a case of giant lymph node hyperplasia that presented as a right supraclavicular mass in an asymptomatic two-month-old female infant. Clinically, the mass was thought to be either a lipoma or a cystic hygroma,...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/91.3.344

    authors： Hunt SJ,Anderson WD

    更新日期：1989-03-01 00:00:00

  • Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature.

    abstract：:Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章,评审

    doi：10.1093/ajcp/93.6.795

    authors： Ballance WA,Ro JY,el-Naggar AK,Grignon DJ,Ayala AG,Romsdahl MG

    更新日期：1990-06-01 00:00:00

  • Determination of terminal deoxynucleotidyl transferase on bone marrow smears by immunoperoxidase.

    abstract：:Terminal deoxynucleotidyl transferase (TdT) is a marker of lymphoblastic disorders. Previously, the technique for determining TdT on smears was by indirect immunofluorescence. An immunoperoxidase procedure for detecting TdT on smears is reported. Results are in a comparable range with the indirect immunofluorescent te...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/77.2.174

    authors： Stass SA,Dean L,Peiper SC,Bollum FJ

    更新日期：1982-02-01 00:00:00

  • Fine-Needle Aspiration Features of BCOR-CCNB3 Sarcoma.

    abstract：OBJECTIVES:BCOR-CCNB3 sarcoma (BCS) is an undifferentiated tumor that has some clinical and morphologic similarity to classic Ewing sarcoma, but it is characterized by a distinct BCOR-CCNB3 gene fusion. There are no reports describing its cytomorphologic findings. METHODS:We describe cytologic findings of five molecul...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/aqz159

    authors： Gajdzis P,Laé M,Pierron G,Brisse HJ,Orbach D,Fréneaux P,Laurence V,Klijanienko J

    更新日期：2020-02-08 00:00:00

  • Prognostic features in patients with stage T1 breast carcinoma and a 0.5-cm or less lymph node metastasis. Significance of lymph node hilar tissue invasion.

    abstract：:Trends in surgical practice suggest that pathologists will encounter increased numbers of patients with small invasive ductal adenocarcinomas; small, if any, metastatic deposits in axillary lymph nodes (ALNs); and possibly fewer ALN specimens to examine. New prognostic histologic features may be needed in this environ...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/111.1.21

    authors： Goldstein NS,Mani A,Vicini F,Ingold J

    更新日期：1999-01-01 00:00:00

  • Pathology archive: evaluation of integrity, regulatory compliance, and construction of searchable database from print reports.

    abstract：:Tissue repositories maintained by pathology departments represent an abundant resource of clinically annotated human specimens. The storage expenses associated with pathology archives are known to administrators of most pathology departments. However, such basic repository characteristics as the quality of stored mate...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/AJCP3CVA2NAVUUVU

    authors： Smith MA,Barnes EL,Chiosea SI

    更新日期：2011-05-01 00:00:00

  • Expanded populations of surface membrane immunoglobulin light chain-negative B cells in lymph nodes are not always indicative of B-cell lymphoma.

    abstract：:Immunophenotypic analysis is useful in distinguishing reactive from neoplastic lymphoproliferations, particularly when tissue is limited or histologic findings are equivocal. Surface membrane immunoglobulin (SmIg) light chain restriction in B cells is especially helpful in documenting clonality, and the loss of SmIg b...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/5R76B01VCATQLBK6

    authors： Zhao XF,Cherian S,Sargent R,Seethala R,Bonner H,Greenberg B,Bagg A

    更新日期：2005-07-01 00:00:00

  • Pathology and medical malpractice. Academic and trainee empirical review of cases by State of Texas physicians.

    abstract：OBJECTIVES:This study examines whether the assumptions that pathologists understand the medical malpractice negligence rule and have a clear single standard of care are reasonable. METHODS:Two hundred eighty-one Texas academic pathologists and trainees were presented 10 actual pathology malpractice cases from publicly...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/AJCPQLK63BQFDODF

    authors： Allen TC,Stafford M,Liang BA

    更新日期：2014-04-01 00:00:00

  • Evaluation of the ASTRA o-cresolphthalein complexone calcium method.

    abstract：:An automated calcium method based on o-cresolphthalein complexone chemistry and designed to be used in conjunction with the Beckman ASTRA systems (Beckman Instruments, Inc., Brea, CA) was evaluated. Day-to-day reproducibility studies yielded coefficients of variation ranging from 1.2 to 3.1%. Linearity was 5.0-15.5 mg...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/82.2.182

    authors： Hartmann AE,Lewis LR

    更新日期：1984-08-01 00:00:00

  • The clinical significance of eosinophiluria.

    abstract：:Eosinophils are normally absent from the urine. Their presence has been associated with a variety of clinical conditions affecting the kidney or urinary tract. The authors examined the clinical significance and eosinophils, in particular, for acute interstitial nephritis. ...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/88.4.520

    authors： Corwin HL,Haber MH

    更新日期：1987-10-01 00:00:00

  • The LAST guidelines in clinical practice: implementing recommendations for p16 use.

    abstract：OBJECTIVES:To determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared p16 use and follow-up data before and after implementation of the guidelines. METHODS:We reviewed all cervical biopsy specimens diagnosed by two...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/AJCPUXLP7XD8OQYY

    authors： Clinton LK,Miyazaki K,Ayabe A,Davis J,Tauchi-Nishi P,Shimizu D

    更新日期：2015-12-01 00:00:00

  • A diagnostic expert system for colonic lesions.

    abstract：:The diagnostic expert system for colonic lesions (DESCL) was designed to discriminate colonic adenoma and adenocarcinoma from normal colonic tissue. Although it was originally developed for use in conjunction with a machine vision analytic system, the DESCL has evolved into a teaching tool and a model for conceptual m...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章,评审

    doi：

    authors： Graham AR,Paplanus SH,Bartels PH

    更新日期：1990-10-01 00:00:00

  • Presence of t(8;21)(q22;q22) in myeloperoxidase-positive, myeloid surface antigen-negative acute myeloid leukemia.

    abstract：:Although acute myeloid leukemias (AMLs) cytochemically negative for myeloperoxidase are now well recognized, myeloid surface antigen-negative AMLs are rare. The morphologic, cytochemical, immunologic, and cytogenetic or molecular features of such cases are described in four adults aged 19 to 60 years. All had AML with...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/107.1.68

    authors： Arber DA,Glackin C,Lowe G,Medeiros LJ,Slovak ML

    更新日期：1997-01-01 00:00:00

  • Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children.

    abstract：:The development of a precise, mathematical relationship between blood pressure and renal microvascular abnormalities would be highly desirable. Such a relationship would require that abnormalities be quantitative on a rational scale. The dominant abnormality in nephrosclerosis occurs in arcuate and cortical arteries o...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/85.3.312

    authors： Tracy RE,Mercante DE,Moncada A,Berenson G

    更新日期：1986-03-01 00:00:00

  • A hospital-wide outbreak of septicemia due to a few strains of Staphylococcus aureus.

    abstract：:During a 6-month period at Walter Reed Army Hospital the monthly attack rate of Staphylococcus aureus bacteremia increased to 3.8 +/- 0.5 (mean +/- SEM) from 2.5 +/- 0.2 cases per 1,000 dispositions for the previous 48 months (P less than 0.05). A predominant phage pattern, designated S, was found in 12 (39%) of 31 ba...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/79.5.598

    authors： Cross AS,Zierdt CH,Roup B,Almazan R,Swan JC

    更新日期：1983-05-01 00:00:00

  • In vitro detection of mild inhibitors to factor VIII in hemophilia.

    abstract：:Plasma samples from patients with severe classic hemophilia, suspected of having mild inhibitors not detected in the standard Bethesda inhibitor test, were examined in modified Bethesda tests and in a screening test based on the activated partial thromboplastin time (APTT). The APTT test was more sensitive to mild inh...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/77.6.749

    authors： Ewing NP,Kasper CK

    更新日期：1982-06-01 00:00:00

  • A new Mycobacterium species causing diffuse lepromatous leprosy.

    abstract：:Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purifie...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1309/AJCPP72FJZZRRVMM

    authors： Han XY,Seo YH,Sizer KC,Schoberle T,May GS,Spencer JS,Li W,Nair RG

    更新日期：2008-12-01 00:00:00

  • The evaluation of factor VIII binding activity of von Willebrand factor by means of an ELISA method: significance and practical implications.

    abstract：:One of the functions of von Willebrand factor (vWF) is to serve as a carrier of clotting factor VIII (FVIII). Deficiency of this function results in the von Willebrand disease (vWD) variant type 2N, which resembles hemophilia A. We describe a new sandwich enzyme-linked immunosorbent assay (ELISA) to study the ability ...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/109.3.347

    authors： Casonato A,Pontara E,Zerbinati P,Zucchetto A,Girolami A

    更新日期：1998-03-01 00:00:00

  • Chronic granulocytic leukemia without the Philadelphia chromosome.

    abstract：:Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted to the National Cancer Institute since 1961. Twenty patients lacked the Philadelphia (Ph1) chromosome. All were previously untreated. When compared with Ph1-positive patients, CGL pa...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/65.4.467

    authors： Canellos GP,Whang-Peng J,DeVita VT

    更新日期：1976-04-01 00:00:00

  • Identification of monoclonal immunoglobulins and quantitative immunoglobulin abnormalities in hairy cell leukemia and chronic lymphocytic leukemia.

    abstract：:Serum and urine samples from 161 cases of hairy cell leukemia (HCL) and 50 cases of chronic lymphocytic leukemia (CLL) were analyzed for monoclonal immunoglobulin (MIg) by using a combination of high-resolution protein electrophoresis, immunoelectrophoresis, and immunofixation. Quantitative immunoglobulin analysis als...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/102.5.580

    authors： Hansen DA,Robbins BA,Bylund DJ,Piro LD,Saven A,Ellison DJ

    更新日期：1994-11-01 00:00:00

  • Aberrations of chromosomes 9 and 17 in bilharzial bladder cancer as detected by fluorescence in situ hybridization.

    abstract：:Fluorescence in situ hybridization (FISH), using repetitive alpha satellite probes to chromosomes 9 and 17, was performed on 27 paraffinembedded bladder specimens from 18 Egyptian patients affected with bilharzial carcinoma. Fluorescence in situ hybridization results in the carcinomas and benign mucosa of patients wit...

    journal_title：American journal of clinical pathology

    pub_type： 杂志文章

    doi：10.1093/ajcp/106.2.234

    authors： Ghaleb AH,Pizzolo JG,Melamed MR

    更新日期：1996-08-01 00:00:00