Clinical and pathologic findings of the liver in the acquired immune deficiency syndrome (AIDS).

Abstract:

:Clinical data and histologic sections of the liver, including immunohistochemical studies for hepatitis B surface and core antigens, were reviewed in 42 autopsy cases of the acquired immune deficiency syndrome (AIDS). Hepatomegaly, elevation of serum transaminases, and mild elevation of alkaline phosphatase were commonly observed clinical and biochemical abnormalities. Mildly elevated alkaline phosphatase and normal bilirubin levels were present in patients with Mycobacterium avium-intracellulare (MAI) infection, cytomegalovirus (CMV) infection, and Kaposi's sarcoma (KS). Histologic sections demonstrated liver involvement by MAI in eight cases; KS in six cases; cryptococcus in three cases; and CMV in two cases. One case of MAI infection was associated with marked central vein sclerosis, a finding previously unreported. Thirty-two (76%) of 42 cases had serologic or pathologic evidence of hepatitis exposure. Two patients had histologic evidence of chronic active hepatitis. The pathologic processes involving the liver appeared to be secondary to the infections and neoplasms for which this population is susceptible and did not significantly contribute to morbidity or mortality. No findings specific or pathognomic for AIDS were identified in the liver.

journal_name

Am J Clin Pathol

authors

Glasgow BJ,Anders K,Layfield LJ,Steinsapir KD,Gitnick GL,Lewin KJ

doi

10.1093/ajcp/83.5.582

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

582-8

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

83

pub_type

杂志文章
  • Apocrine mammary carcinoma. A clinicopathologic study of 72 cases.

    abstract::Apocrine carcinoma (AC) is an uncommon, poorly characterized type of breast tumor. In this review, 55 patients with intraductal (ID) AC and 17 patients with infiltrating (IF) AC were analyzed retrospectively to define the histologic features and clinical course of this neoplasm. Recurrences in the breast occurred in 3...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.4.371

    authors: Abati AD,Kimmel M,Rosen PP

    更新日期:1990-10-01 00:00:00

  • Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54.

    abstract::Two hundred forty-three patients who had pathologically verified primary osteosarcomas of bone, treated at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute over a 24-year period, form the basis of this study. These cases provide a basis for comparison of those patients currentl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.5.427

    authors: Uribe-Botero G,Russell WO,Sutow WW,Martin RG

    更新日期:1977-05-01 00:00:00

  • The current state of resident training in genomic pathology: a comprehensive analysis using the resident in-service examination.

    abstract:OBJECTIVES:To determine the current state of pathology resident training in genomic and molecular pathology. METHODS:The Training Residents in Genomics (TRIG) Working Group developed survey and knowledge questions for the 2013 pathology Resident In-Service Examination (RISE). Sixteen demographic questions related to a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPH2A4XTXJUKDZ

    authors: Haspel RL,Rinder HM,Frank KM,Wagner J,Ali AM,Fisher PB,Parks ER,Training Residents in Genomics (TRIG) Working Group.

    更新日期:2014-10-01 00:00:00

  • Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis.

    abstract::Acute toxic hepatic necrosis is common and may be fatal. Predicting clinical outcome may be aided by following serum markers that could indicate recovery or may signify massive (substantial) destruction of functional liver mass. Previously, in a published case of chloroform poisoning, we serially assayed serum biomark...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/112.3.351

    authors: Horn KD,Wax P,Schneider SM,Martin TG,Nine JS,Moraca MA,Virji MA,Aronica PA,Rao KN

    更新日期:1999-09-01 00:00:00

  • Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H.

    abstract::The role of viruses in several renal diseases is not documented clearly. The authors attempted to localize envelope glycoproteins of Hantaan virus in biopsy specimens from patients with Korean hemorrhagic fever (KHF) as evidence of direct viral invasion of renal tissues. The authors studied sequential sections of kidn...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.398

    authors: Kim S,Kang ET,Kim YG,Han JS,Lee JS,Kim YI,Hall WC,Dalrymple JM,Peters CJ

    更新日期:1993-10-01 00:00:00

  • HER2 protein expression and gene amplification in androgen-independent prostate cancer.

    abstract::The role of the HER2 receptor remains uncertain in the pathogenesis and progression of human prostate cancer. Previous studies have reported widely divergent rates for HER2 expression in primary prostate tumors, probably owing to significant methodologic differences in the studies. Few data exist about the frequency o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/VXKK-YVRH-9B11-YDPT

    authors: Reese DM,Small EJ,Magrane G,Waldman FM,Chew K,Sudilovsky D

    更新日期:2001-08-01 00:00:00

  • SATB2 in Neoplasms of Lung, Pancreatobiliary, and Gastrointestinal Origins.

    abstract:OBJECTIVES:Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, and pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa118

    authors: De Michele S,Remotti HE,Del Portillo A,Lagana SM,Szabolcs M,Saqi A

    更新日期:2021-01-04 00:00:00

  • A useful antibody panel for differential diagnosis between peritoneal mesothelioma and ovarian serous carcinoma in Japanese cases.

    abstract::Malignant mesothelioma is increasing in incidence worldwide, including in Japan. However, the accurate pathologic diagnosis of pleural or peritoneal mesothelioma (PM) is sometimes difficult if adequate histologic and immunohistochemical analyses are not undertaken. The aim of this study was to identify a useful antibo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPHSUJ15NEYMIP

    authors: Takeshima Y,Amatya VJ,Kushitani K,Inai K

    更新日期:2008-11-01 00:00:00

  • Workload recording by microcomputer.

    abstract::Workload recording as designed by the College of American Pathologists has proven to be an invaluable aid in the assessment of overall laboratory operation. The administrative information derived from the compilation of these workload statistics is utilized to provide effective and these workload statistics is utilize...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.4.469

    authors: Norbut AM,Foulis PR,Mendelow H

    更新日期:1980-10-01 00:00:00

  • Genotypic and immunophenotypic characterization of two human light chain-only B-cell non-Hodgkin's lymphomas.

    abstract::Two atypical human non-Hodgkin's lymphomas (NHLs) that exhibited unusual genotypic and in situ immunophenotypic abnormalities are described. Immunophenotypically, both NHLs lacked surface Ig heavy chains. With the exception of the MB2 B-cell-associated antigen, no B- and T-cell differentiation antigen was detected in ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.4.390

    authors: De Re V,Carbone A,Dolcetti R,Tirelli U,Folegotto C,Boiocchi M

    更新日期:1990-10-01 00:00:00

  • Evaluation of the DCL Syphilis-G enzyme immunoassay test kit for the serologic diagnosis of syphilis.

    abstract::Sera have been submitted to the authors' laboratory for syphilis testing at a dramatically increased rate since the start of the human immunodeficiency virus type 1 epidemic. Thus they were interested in evaluating a new enzyme immunoassay, the DCL Syphilis-G test kit (DCL-G, Diagnostic Chemicals Ltd., Oxford, CT) for...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.3.282

    authors: Nayar R,Campos JM

    更新日期:1993-03-01 00:00:00

  • Immunohistochemical characterization of renal amyloidosis.

    abstract::Forty-five renal biopsies with amyloidosis were studied by light microscopy with Congo red staining and action of potassium permanganate and by immunofluorescence with antihuman tissue A component antiserum antilight and heavy chains of immunoglobulins antisera. The patients were classified on the basis of concordance...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.6.756

    authors: Noel LH,Droz D,Ganeval D

    更新日期:1987-06-01 00:00:00

  • Uterine tumors resembling ovarian sex-cord tumors. A clinicopathologic analysis of fourteen cases.

    abstract::Uterine tumors with histologic resemblances to ovarian sex-cord tumors were encountered in 14 women in the fourth to sixth decades of life, most of whom had abnormal vaginal bleeding and enlarged uteri suggesting leiomyomas. The tumors in six cases (Group I) were identical to one or another form of well-recognized end...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.3.512

    authors: Clement PB,Scully RE

    更新日期:1976-09-01 00:00:00

  • The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors.

    abstract::The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.3.286

    authors: Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

    更新日期:1998-03-01 00:00:00

  • Cancer tracking: Clinician compliance and program outcome.

    abstract:OBJECTIVES:Certain laboratory tests are critical for patient care and must be communicated rapidly. Professional societies have developed guidelines for reporting of "critical values" and significant or unexpected surgical pathology findings. Urgent diagnoses requiring rapid reporting include new or unexpected diagnose...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPJHFVORM48IZL

    authors: Layfield LJ,Schnabel JL

    更新日期:2014-12-01 00:00:00

  • Heterogenous expression of endothelial cell markers in infantile hemangioendothelioma. Immunohistochemical study of two solitary cases and one multiple one.

    abstract::Three cases of infantile hemangioendothelioma were immunohistochemically studied with the use of antibodies against von Willebrand factor (vWF), Ulex europaeus I lectin (UEA I), vimentin, thrombomodulin (TM), and actin, as endothelial cell (EC) markers. Because of a broad variety of histologic features, the growth pat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.6.673

    authors: Yasunaga C,Sueishi K,Ohgami H,Suita S,Kawanami T

    更新日期:1989-06-01 00:00:00

  • Heparin cofactor II assay. Elimination of heparin and antithrombin-III effects.

    abstract::Functional assays for heparin cofactor II (HC-II) are based on the inactivation of thrombin by HC-II in the presence of dermatan sulfate (DS). Residual thrombin is measured in a chromogenic assay. Interference by the antithrombin-III (AT-III)/heparin complex, which also rapidly inactivates thrombin, must be eliminated...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.3.353

    authors: Nakhleh R,Vogt JM,Edson JR

    更新日期:1988-03-01 00:00:00

  • The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening.

    abstract::Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement of RBC subpopulations is now available on the Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe the new formulas: % microcytic - % hypochromic; and % microcytic - % hypochromic - red cell distributio...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPJRH1I0XTNFGA

    authors: Urrechaga E,Borque L,Escanero JF

    更新日期:2011-03-01 00:00:00

  • Morphonuclear relationship between prostatic intraepithelial neoplasia and cancers as assessed by digital cell image analysis.

    abstract::Using digital cell image analysis performed on Feulgen-stained nuclei, the nuclear characteristics of prostatic neoplasia, ranging from benign (benign prostatic hyperplasia [BPH]), through dysplastic (prostatic intraepithelial neoplasia [PIN] 1-3), to carcinoma were studied. Four histopathologic groups were studied: g...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.5.628

    authors: Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

    更新日期:1991-11-01 00:00:00

  • Can mucinous lesions of the breast be reliably diagnosed by core needle biopsy?

    abstract::Lesions of the breast containing extravasated mucin span a continuum from benign mucoceles to invasive mucinous (colloid) carcinoma. It is well known that distinguishing benign from malignant mucinous lesions is difficult infine-needle aspiration material. Whether these lesions also are difficult to distinguish in cor...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/TP6Y-Q0QR-XXVQ-9MJ5

    authors: Renshaw AA

    更新日期:2002-07-01 00:00:00

  • Screening test for complement activation by counterimmunoelectrophoresis.

    abstract::This report describes the use of counterimmunoelectrophoresis (CIE) as a method of detecting activation of the complement system. With this technic small amounts of C3 split products (C3c/d) can be detected in plasma samples by specific precipitation with antiserum in less than two hours. The CIE technic is a highly s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.4.440

    authors: Arroyave CM,Taylor DG,Gallup P,Nakamura RM

    更新日期:1978-04-01 00:00:00

  • Myelodysplasia in the acquired immune deficiency syndrome.

    abstract::Certain new hematologic findings in eight homosexual or bisexual patients with the acquired immune deficiency syndrome (AIDS) are presented. All eight patients manifested a normochromic, normocytic anemia, and six of eight had granulocytopenia during their hospitalization. The other two had low-normal granulocyte coun...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.2.144

    authors: Schneider DR,Picker LJ

    更新日期:1985-08-01 00:00:00

  • Assessment of interlaboratory variation in the immunohistochemical determination of estrogen receptor status using a breast cancer tissue microarray.

    abstract::The determination of tumor cell estrogen receptor (ER) expression status by immunohistochemical analysis has become standard practice, yet assay reproducibility has not been assessed adequately. By using a breast cancer tissue microarray, we examined interlaboratory variability in ER reporting. A 2-fold redundant tiss...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/PEF8-GL6F-YWMC-AG56

    authors: Parker RL,Huntsman DG,Lesack DW,Cupples JB,Grant DR,Akbari M,Gilks CB

    更新日期:2002-05-01 00:00:00

  • A quantitative histologic comparison of the thymus in 100 healthy and diseased adults.

    abstract::The characteristics of the normal adult thymus in both sexes were determined in 50 cases of accidental death by a simplified quantitative histologic technic. A table of normal values derived from these findings was used for making comparisons with thymus from autopsies of 50 additional patients suffering terminal illn...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.5.657

    authors: Smith SM,Ossa-Gomez LJ

    更新日期:1981-11-01 00:00:00

  • False positive indirect fluorescent antibody (IFA) tests for antibody to herpes simplex virus 1. Comparison of four commercially available methods.

    abstract::Four commercially available herpes simplex virus 1 (HSV-1) indirect fluorescent antibody (IFA) kits were compared with the use of sera selected because they were negative for HSV antibody by complement fixation (CF less than 1:8) and by ELISA (less than 1:100). However, 14 of 24 (58.3%) of these HSV-1 antibody-negativ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.6.765

    authors: Rand KH,Houck HJ,Dickinson M

    更新日期:1986-12-01 00:00:00

  • Determination of urinary homovanillic acid using the nitrosonaphthol reaction.

    abstract::Determination of urinary homovanillic acid (HVA) is an important analysis to establish the diagnosis and prognosis of neuroblastoma. A method is presented for the determination of this metabolite of dopamine using its reaction with 1-nitroso-2-naphthol and nitrous acid. The method has shown a sensitivity, specificity,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.5.644

    authors: Rothstein A

    更新日期:1987-05-01 00:00:00

  • Challenging identification of a novel PiISF and the rare PiMmaltonZ α1-antitrypsin deficiency variants in two patients.

    abstract:OBJECTIVES:α1-Antitrypsin (AAT) deficiency is associated with an increased risk for lung and liver disease. Identification of AAT deficiency as the underlying cause of these diseases is important in correct patient management. METHODS:AAT deficiency is commonly diagnosed by demonstrating low concentrations of AAT foll...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPR7EIQS8PIMLV

    authors: Suh-Lailam BB,Procter M,Krautscheid P,Haas J,Kumar S,Mao R,Grenache DG

    更新日期:2014-05-01 00:00:00

  • Review of negative Papanicolaou tests. Is the retrospective 5-year review necessary?

    abstract::New federal regulations require review of all available negative gynecologic smears within the previous 5 years for each patient with a current high grade squamous intraepithelial lesion (HGSIL) or above. Two university hospitals retrospectively reviewed all patients who had HGSIL or above and who had prior negative s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.1.19

    authors: Allen KA,Zaleski S,Cohen MB

    更新日期:1994-01-01 00:00:00

  • T-cell malignancy following B-cell lymphoma in remission.

    abstract::A T-cell malignancy developed in a 64-year-old man with recurrent B-cell lymphoma after one and a half years of remission. Immunophenotypic and DNA analyses confirmed clonality and cell lineage of both lymphoid malignancies. Sequential development of B- and T-cell malignancies in this patient may be an example of bicl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.3.362

    authors: Shimizu K,Hirano M,Maruyama F,Itoh M,Hara K,Ino T,Ezaki K,Kunii A

    更新日期:1989-09-01 00:00:00

  • HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer.

    abstract:Objectives:Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw211

    authors: Hou Y,Nitta H,Li Z

    更新日期:2017-01-01 00:00:00