T-cell malignancy following B-cell lymphoma in remission.

abstract：:New federal regulations require review of all available negative gynecologic smears within the previous 5 years for each patient with a current high grade squamous intraepithelial lesion (HGSIL) or above. Two university hospitals retrospectively reviewed all patients who had HGSIL or above and who had prior negative s...

journal_title：American journal of clinical pathology

authors： Allen KA,Zaleski S,Cohen MB

更新日期：1994-01-01 00:00:00

abstract：:A 67-year-old man presented with a malignant tumor involving abdominal lymph nodes, spleen, liver, and lungs, with associated protracted fever and night sweats. The tumor consisted of large pleomorphic cells, often surrounding microabscesses. Intracytoplasmic S100 protein, surface T6, Leu-3a (T4), and HLA-DR antigens ...

journal_title：American journal of clinical pathology

authors： Chan WC,Zaatari G

更新日期：1986-06-01 00:00:00

abstract：:In 1985 Harvard Medical School initiated an experimental curriculum that incorporated many of the recommendations of the report on the General Professional Education of the Physician (GPEP). Key features are problem-based small group tutorials that emphasize active learning, with increased independent study time and a...

journal_title：American journal of clinical pathology

authors： Colvin RB,Wetzel MS

更新日期：1989-10-01 00:00:00

abstract：OBJECTIVES:To investigate the prognostic utility of multifocal extraprostatic extension (EPE) on biochemical recurrence after radical prostatectomy. METHODS:We conducted retrospective analysis of biochemical recurrence and prognostic pathologic variables in 673 men with stage pT3a/pT3b prostate cancer from 2000 to 201...

journal_title：American journal of clinical pathology

authors： Farchoukh L,Laframboise WA,Nelson JB,Bastacky S,Parwani AV,Dhir R

更新日期：2020-03-09 00:00:00

abstract：:Bull's algorithm has been evaluated by computer simulation studies. Varying amounts of systematic analytic error were simulated in either hemoglobin (Hgb), red blood cell count (RBC), or mean corpuscular volume (MCV) with the resulting red blood cell indices averaged in batches of 20 using Bull's algorithm. The number...

journal_title：American journal of clinical pathology

authors： Cembrowski GS,Westgard JO

更新日期：1985-03-01 00:00:00

abstract：:A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...

journal_title：American journal of clinical pathology

authors： Rosenfeld CS,Nichols G,Bodensteiner DC

更新日期：1987-04-01 00:00:00

abstract：:We used a panel of paraffin antibodies to determine whether neoplastic and nonneoplastic lymphoid aggregates in the bone marrow can be distinguished reliably. Formalin-fixed, paraffin-embedded bone marrow core biopsy specimens with lymphoid aggregates were stained using primary antibodies directed against bcl-2, bcl-6...

journal_title：American journal of clinical pathology

authors： West RB,Warnke RA,Natkunam Y

更新日期：2002-04-01 00:00:00

abstract：:The authors investigated assays for free protein S (ProS) antigen, total ProS antigen, and ProS crossed immunoelectrophoresis (CIEP) in the diagnosis of type 1 inherited ProS deficiency. Accurate measurement of the hemostatically important free ProS required showing that, on each specimen, precipitation of the C4b-bin...

journal_title：American journal of clinical pathology

authors： Edson JR,Vogt JM,Huesman DA

更新日期：1990-08-01 00:00:00

abstract：Objectives:The plasma-thrombin method is commonly used to make cell blocks from fine-needle aspiration (FNA) samples but requires centrifugation. We describe a modification to this method that does not require centrifugation for use in resource-limited settings. Methods:Pooled fresh plasma is aliquoted into 2-mL Eppen...

journal_title：American journal of clinical pathology

authors： Aisagbonhi O,Birungi A,Atwine R,Behayo P,Ayebaziwe B,Roberts D,Tambouret R

更新日期：2018-07-03 00:00:00

abstract：:Abbreviated pretransfusion testing, although permitted by American Association of Blood Banks Standards for unimmunized patients, is not widely practiced. Concerns remain about optimal antibody screening methods, antibodies missed by deleting the antiglobulin crossmatch, and cost-effectiveness. The authors prospective...

journal_title：American journal of clinical pathology

authors： Cordle DG,Strauss RG,Snyder EL,Floss AM

更新日期：1990-10-01 00:00:00

abstract：:Using digital cell image analysis performed on Feulgen-stained nuclei, the nuclear characteristics of prostatic neoplasia, ranging from benign (benign prostatic hyperplasia [BPH]), through dysplastic (prostatic intraepithelial neoplasia [PIN] 1-3), to carcinoma were studied. Four histopathologic groups were studied: g...

journal_title：American journal of clinical pathology

authors： Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

更新日期：1991-11-01 00:00:00

abstract：:Immunophenotypic analysis is useful in distinguishing reactive from neoplastic lymphoproliferations, particularly when tissue is limited or histologic findings are equivocal. Surface membrane immunoglobulin (SmIg) light chain restriction in B cells is especially helpful in documenting clonality, and the loss of SmIg b...

journal_title：American journal of clinical pathology

authors： Zhao XF,Cherian S,Sargent R,Seethala R,Bonner H,Greenberg B,Bagg A

更新日期：2005-07-01 00:00:00

abstract：:In 10 cases of Barrett adenocarcinoma, samples from 8 tumor areas (including superficial and deep from peripheral and central areas) and a regional lymph node metastasis were studied for amplification of c-myc, c-erbB-2, and EGFR. We analyzed loss of heterozygosity (LOH) at 3 loci (APC, MCC, and RB) and 2 anonymous mi...

journal_title：American journal of clinical pathology

authors： Owonikoko T,Rees M,Gabbert HE,Sarbia M

更新日期：2002-04-01 00:00:00

abstract：:To investigate the effect of matrix-degrading enzymes on the malignant potential of oral squamous cell carcinoma, the expression of matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for oral cancer was studied immunohistochemically. In 20 of 26 patients (76.9%)...

journal_title：American journal of clinical pathology

authors： Kusukawa J,Sasaguri Y,Shima I,Kameyama T,Morimatsu M

更新日期：1993-01-01 00:00:00

abstract：:Breast cancer is the result of a multistage carcinogenic process. Initiation, promotion, dependency and autonomy make up a sequence of experimentally distinguishable phases of this process. Progression--the transition from dependency on hormonal support to autonomy--is demonstrable clinically. High-affinity saturatabl...

journal_title：American journal of clinical pathology

authors： Brennan MJ

更新日期：1975-12-01 00:00:00

abstract：:Descriptive reports of liver histologic features in celiac disease (CD) are sparse, and the effect of a gluten-free diet (GFD) on the course of liver injury is poorly understood. We reviewed liver biopsy specimens in 30 patients with CD and performed immunostains for IgG, IgG4, IgM, and IgA. Subsequent liver biochemic...

journal_title：American journal of clinical pathology

authors： Mounajjed T,Oxentenko A,Shmidt E,Smyrk T

更新日期：2011-07-01 00:00:00

abstract：:The authors quantified creatine kinase MB (CK-MB) isoenzyme activity and mass in the serum of 81 uremic and 20 nonuremic (control) patients who had no clinical or electrocardiographic evidence of acute myocardial infarction. CK-MB was quantified by three methods: electrophoresis, the QuiCK-MB (International Immunoassa...

journal_title：American journal of clinical pathology

authors： Medeiros LJ,Schotte D,Gerson B

更新日期：1987-01-01 00:00:00

abstract：:Reported is a case of lymphoma which was preceded for nine years by an apparently reactive lymphadenopathy. Original slides of the multiple lymphoid tissue samples are reviewed, with emphasis on the gradually increasing numbers of mitoses, atypical histiocytes, and eosinophils, suggestive of malignant transformation. ...

journal_title：American journal of clinical pathology

authors： Hyland CH,Murad TM,Dismukes WE

更新日期：1977-11-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) is characterized by typical morphologic features and the CD5+, CD23-immunophenotype. However, some morphologically typical MCLs are CD23+. A t(11;14)(q13;q32) translocation is frequently found in MCL, leading to overexpression of cyclin D1. We studied the expression of cyclin D1 in 50 small ...

journal_title：American journal of clinical pathology

authors： Peghini PE,Fehr J

更新日期：2002-02-01 00:00:00

abstract：:By studying more than 1,200 patients with cutaneous melanoma and long-term follow-up, I examined the relationship between solar elastosis and age at diagnosis of melanoma, key features of melanoma, and the outcome of overall survival in melanoma. I found that melanomas with elastosis were diagnosed significantly later...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:B-lymphoblastic leukemia (B-LBL) arising in patients with chronic lymphocytic leukemia (CLL) is exceedingly rare and poorly characterized. METHODS:We describe four patients with CLL and concurrent or subsequent B-LBL diagnosed by morphologic, immunophenotypic, cytogenetic, and molecular analysis and reviewe...

journal_title：American journal of clinical pathology

authors： Chakhachiro Z,Yin CC,Abruzzo LV,Aladily TN,Barron LL,Banks HE,Thomas DA,Keating M,Medeiros LJ,Huh YO

更新日期：2015-08-01 00:00:00

abstract：:We report serum enzyme patterns in three patients with polymyositis or dermatomyositis whose cases posed potential problems in distinguishing malignancy, hepatocellular damage, and myocardial infarction from myositis. The alanine aminotransferase showed five- to 16-fold elevations. The creatine kinase MB isoenzyme and...

journal_title：American journal of clinical pathology

authors： Morton BD 3rd,Statland BE

更新日期：1980-04-01 00:00:00

abstract：:Primary massive ovarian edema is uncommon, particularly when it involves both ovaries before puberty. Ovarian edema secondary to a preexisting ovarian lesion is one of the postulated mechanisms. A prepubertal girl presented with bilateral massive ovarian edema with stromal hyperthecosis, which may have predisposed bot...

journal_title：American journal of clinical pathology

authors： Lacson AG,Alrabeeah A,Gillis DA,Salisbury S,Grantmyre EB

更新日期：1989-05-01 00:00:00

abstract：:After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurren...

journal_title：American journal of clinical pathology

authors： Yesus YW,Akhter JE

更新日期：1985-12-01 00:00:00

abstract：:The diagnostic value of glypican 3 (GPC3) immunostaining on needle biopsy specimens has not been well assessed. In this study, 120 liver needle biopsy specimens, including 46 from cirrhotic livers and 74 hepatocellular carcinomas (HCCs), were immunohistochemically examined for expression of GPC3. The results showed st...

journal_title：American journal of clinical pathology

authors： Anatelli F,Chuang ST,Yang XJ,Wang HL

更新日期：2008-08-01 00:00:00

abstract：:The standard method for detecting antinuclear antibodies (ANAs) is by immunofluorescence assay (IFA), a method that is labor intensive and subjective. In an attempt to overcome these limitations, several commercial enzyme immunoassays (EIAs) have been developed. We report the results of our evaluation of the ANA Micro...

journal_title：American journal of clinical pathology

authors： Reisner BS,DiBlasi J,Goel N

更新日期：1999-04-01 00:00:00

abstract：:Endometrial vascular changes similar to atherosclerosis of toxemia of pregnancy were described and graded in 217 consecutive endometrial biopsies of known early intrauterine pregnancy. Severe vascular changes were found in 23.5% of cases. Control material consisting of endometrial biopsies of patients with known cases...

journal_title：American journal of clinical pathology

authors： Lichtig C,Korat A,Deutch M,Brandes JM

更新日期：1988-09-01 00:00:00

abstract：:Two cases of papillary cystic tumor (PCT) of the pancreas were investigated for the presence of estrogen receptors (ERs) and progesterone receptors (PgRs). Both PCT and normal pancreas are able to specifically bind 3H-estradiol. This binding almost exclusively results from the presence of high levels of type II ER, wh...

journal_title：American journal of clinical pathology

authors： Carbone A,Ranelletti FO,Rinelli A,Vecchio FM,Lauriola L,Piantelli M,Capelli A

更新日期：1989-11-01 00:00:00

abstract：:Two cases of Actinomyces viscosus infection of the lungs were seen in nonimmunosuppressed patients. One patient had a peripheral actinomycotic lung mass resembling a tumor. Both patients responded to a long course of penicillin therapy. Reports of A. viscosus infections are rare, although the organism colonizes the mo...

journal_title：American journal of clinical pathology

authors： Eng RH,Corrado ML,Cleri D,Cherubin C,Goldstein EJ

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVES:Bone marrow (BM) biopsy specimens involved by systemic mastocytosis (SM) typically show multifocal, compact, dense aggregates of spindled mast cells (MCs). However, some cases lack aggregate formation and fulfill the World Health Organization 2008 criteria for SM, based on minor criteria. METHODS:We identif...

journal_title：American journal of clinical pathology

authors： Reichard KK,Chen D,Pardanani A,McClure RF,Howard MT,Kurtin PJ,Wood AJ,Ketterling RP,King RL,He R,Morice WG,Hanson CA

更新日期：2015-09-01 00:00:00