Abstract：
:Breast cancer is the result of a multistage carcinogenic process. Initiation, promotion, dependency and autonomy make up a sequence of experimentally distinguishable phases of this process. Progression--the transition from dependency on hormonal support to autonomy--is demonstrable clinically. High-affinity saturatable estrogen binding by breast cancer cytosols distinguishes endocrine-responsive mammary neoplasms from autonomous breast cancers. Approximately 70% of neoplasms containing estrogen-recepor protein at a level of 2.5 femtomoles per mg. protein or higher regress after endocrine ablation (ovariectomy in premenopausal women; adrenalectomy or hypophysectomy in postmenopausal women). Only about 5% of neoplasms lacking the receptor will respond to these maneuvers. Estrogen-receptor content also predicts clinically for estrogen and androgen responsiveness, and experimentally for prolactin dependency. Fifty per cent of primary breast cancers in women are receptor-positive. Normal breast tissue and benign breast lesions characteristically lack receptor protein. The receptor proteins appear to be induced in neoplastic cells during mammary carcinogenesis in endocrinologic settings where non-cancerous breast cells do not contain free receptor in large amounts and fail to manifest endocrinologic growth stimulation. Implications of these findings for endocrinologic management of disseminated mammary cancer, adjuvant therapy, and breast cancer prevention are discussed.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Brennan MJdoi
10.1093/ajcp/64.6.797subject
Has Abstractpub_date
1975-12-01 00:00:00pages
797-809issue
6eissn
0002-9173issn
1943-7722journal_volume
64pub_type
杂志文章,评审abstract：Objective:T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods:We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 t...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1093/ajcp/aqx146
更新日期：2018-01-29 00:00:00
abstract：:Subsequent to recent disclosures that low serum vitamin B12 results can appear normal using many of the current radioassay methods because of the presence of cobalamin (vitamin B12) analogues in human serum, a number of radioassay kits have become available with modified intrinsic factor preparations and claims of mea...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/74.2.209
更新日期：1980-08-01 00:00:00
abstract：:DRC (dendritic reticulum cell) antigen expression was studied in 38 cases of B-cell lymphomas including follicular lymphoma. The results of this study showed DRC-1 to be expressed in 1/3 of small lymphocytic; 3/3 of mantle zone lymphoma (MZL); 10/10 of follicular, small cleaved; 6/7 of follicular, mixed; 1/2 of follic...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/89.4.488
更新日期：1988-04-01 00:00:00
abstract：:A man was hospitalized with bacteremic Achromobacter xylosoxidans type IIIa pneumonia. The authors are aware of no previously reported similar infections caused by this bacterium. A clinical cure was achieved with a combination of carbenicillin and kanamycin therapy. Microtiter susceptibility testing revealed that car...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/70.4.712
更新日期：1978-10-01 00:00:00
abstract：:Colorectal cancer with microsatellite instability (MSI) may occur sporadically or be inherited in cases of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. However, there is no consensus as to which patients must be tested and how to test MSI. In this study, MSI was tested by immunohistochemical analysis an...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/B0AF-DT52-ETMK-EJBE
更新日期：2006-06-01 00:00:00
abstract：:The relationship between immunohistochemically measured membranous expression of erbB-2 oncoprotein and prognosis in breast cancer is controversial, and the relationship between cytoplasmic positivity and prognosis has been minimally investigated. The clinical course of 300 women with infiltrating breast carcinoma, wh...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/108.4.456
更新日期：1997-10-01 00:00:00
abstract：:The development and general concepts of the Système International d'Unités (SI units) are discussed. The basic and derived quantities and units of the SI used for clinical laboratory data are reviewed. Ranges of normal values for a number of body fluid constituents are given in the units in current general use and in ...
journal_title：American journal of clinical pathology
pub_type： 历史文章,杂志文章
doi：10.1093/ajcp/65.1.2
更新日期：1976-01-01 00:00:00
abstract：:Two cases of giant-cell arteritis of uterus were found incidentally in association with uterine prolapse. One similar case has been reported in the literature. Microscopic examination disclosed fragmentation of the elastic laminae of the myometrial arteries with a giant-cell and mononuclear infiltrate. The relationshi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/65.3.308
更新日期：1976-03-01 00:00:00
abstract：:To increase transplantation access, particularly in living-donor renal transplantation, efforts have been made to overcome the barrier of ABO incompatibility. In adults, the most successful cases have involved renal transplantation. Although the overall goal of reducing antibodies against donor ABO before and after tr...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1309/8W4X9H6F8FTLCGYX
更新日期：2006-06-01 00:00:00
abstract：:High-volume (200 ml) platelet concentrates prepared by discontinuous-flow centrifugation, with counts as high as ca. 2.0 x 10(12)/l, were stored in either 600 ml-capacity polyvinylchloride bags or 800-ml capacity polyethylene bags. Both polyvinylchloride and polyethylene bags appeared adequate for 24-hour storage of p...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/73.3.397
更新日期：1980-03-01 00:00:00
abstract：:To verify their clinical usefulness in diagnosis and early response to therapy of sideropenic anemia, we compared the behavior of the reticulocyte parameter (RET-Y), a raw measure dependent on size and content of the cell, generated by the Sysmex XE 2100, with the mean reticulocyte volume (MCVr) and mean reticulocyte ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/W652-95DT-UWK7-U1HH
更新日期：2004-04-01 00:00:00
abstract：:In situ hybridization with specific RNA radiolabeled probes was used to analyze the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by 21 low-grade follicular lymphomas (FLs). All of the 21 FLs tested contained lymphokine-synthesizing cells in the interfollicular and follicular areas. Enumeration o...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/95.1.55
更新日期：1991-01-01 00:00:00
abstract：:Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells. Our objective was to assess whether the pRb-mediated HPV-suppressive effect of PAI-2 in cancer cell lines has implications in the outcome of HPV infections. Cervical biop...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPQQ07WUTZUTES
更新日期：2009-12-01 00:00:00
abstract：:A case of a patient with otherwise typical multiple myeloma whose myeloma cells were phagocytic is described. Phagocytosis of erythrocytes, erythrocytic precursors, lymphocytes, and platelets was found. Ingestion of latex particles by myeloma cells was demonstrated in vitro. ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/71.6.722
更新日期：1979-06-01 00:00:00
abstract：:This is a report of the histochemical and ultrastructural analysis of nevus cell aggregates in the placenta from a neonate with a giant pigmented nevus. Although the distinction between aberrant migration of neural crest elements and blood-borne metastasis from the giant pigmented nevus is not readily resolved, the au...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1093/ajcp/89.3.395
更新日期：1988-03-01 00:00:00
abstract：:A patient with a polymicrobial bacteremia due to Nocardia asteroides and Escherichia coli is presented. Rapid overgrowth of all cultures with the E. coli necessitated the use of selective media containing antimicrobial agents to which the E. coli was sensitive. Only five previous cases of N. asteroides bacteremia have...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/64.4.537
更新日期：1975-10-01 00:00:00
abstract：:Myxomatous degeneration of the mitral valve is a disease of unknown etiology that is associated with many ominous complications. A case in which non-bacterial thrombotic endocarditis, superimposed on a myxomatous mitral valve, resulted in systemic embolization to the brain, heart, and kidney is presented. The purpose ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/72.3.489
更新日期：1979-09-01 00:00:00
abstract：:We report 2 cases of splenic postchemotherapy histiocyte-rich pseudotumor. Each patient had a history of diffuse large B-cell lymphoma, treated with multiagent chemotherapy. Computed tomography scans performed on both patients showed splenic masses. A positron emission tomography scan performed on 1 patient showed inc...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPC67QOGJXCEZB
更新日期：2009-09-01 00:00:00
abstract：:Immunocytochemical assays for progesterone receptor (PR) using monoclonal antirabbit PR antibodies (PR-ICA) and for estrogen receptor (ER) (ER-ICA) were compared with radioligand binding (dextran-coated charcoal [DCC]) methods for receptor determination in patients with breast cancer. Immunocytochemical staining for P...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Although red blood cell (RBC) antigen typing by agglutination is generally useful, several situations exist where this approach is difficult or impossible. For example, following a massive transfusion, a patient's residual RBCs are mixed with transfused normal donor RBCs. In this case, typing by hemagglutination prima...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.3.353
更新日期：1995-03-01 00:00:00
abstract：:Multicentric osteosarcoma (M-OGS) is characterized by multicentricity of osseous osteosarcomas, either synchronous or metachronous, without visceral involvement. The study's purpose was to clinicopathologically and radiographically analyze 56 cases of M-OGS (22 synchronous and 34 metachronous). The distal femur was th...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCP0V0OATKCNAZP
更新日期：2011-11-01 00:00:00
abstract：:The combined experience of four university medical centers with fine-needle aspiration biopsy (FNAB) of the mediastinum is reviewed. This series includes 189 cases, with 100 males and 89 females, 6 months to 86 years of age. The majority (71%) of diagnoses were neoplastic with the remainder equally distributed between...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1093/ajcp/105.2.168
更新日期：1996-02-01 00:00:00
abstract：OBJECTIVES:We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS:We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPS88CMJRXZBWA
更新日期：2014-06-01 00:00:00
abstract：:The 1973 Comprehensive Blood Bank Survey Program of the College of American Pathologists was administered to 2,200 laboratories and blood banks throughout the United States. The results showed a considerable increase in the accuracy of the testing and in the performance of reagents. Accuracy of ABO testing was 99.3%; ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:Anaerobiospirillum succiniciproducens is a little-known spiral bacterium. Presented here are two septicemia cases similar in that both occurred in rural northern Virginia, both patients presented with dental infection, and in both cases the organism was first suspected to be Campylobacter. The morphology, motility, bi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/85.1.73
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVES:CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. METHODS:Retrospective review of T-PLL cases with com...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqz060
更新日期：2019-09-09 00:00:00
abstract：:The immunochemical characterization of the light chains of the mesangial immunoglobulin A (IgA) deposits were studied in 45 patients with IgA nephropathy. Kappa and lambda light chains were detected with direct immunofluorescence (IF) method, using monospecific rabbit anti-human anti-kappa and anti-lambda anti-sera. T...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/85.5.548
更新日期：1986-05-01 00:00:00
abstract：:The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/80.5.700
更新日期：1983-11-01 00:00:00
abstract：:The finding of monoclonal B-cell lymphocytosis (MBL) raises questions on the nature of clonal cell expansion and its risk of progression. We identified and characterized 7 cases of clinically benign clonal B-cell lymphocytosis. The clonal lymphocytes were clearly of CD5- and non-chronic lymphocytic leukemia (CLL) phen...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/WB56ET6AGM44TM5T
更新日期：2007-08-01 00:00:00
abstract：:By application of combined structural and functional analyses, most lymphoid neoplasms may be categorized as of T- or B-cell origin. T lymphocyte neoplasms include types of acute and chronic lymphocytic leukemias, certain cutaneous and node-based lymphomas, and lymphomas of thymocytes (convoluted lymphocytic lymphomas...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
