Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study.

Abstract:

:To investigate the effect of matrix-degrading enzymes on the malignant potential of oral squamous cell carcinoma, the expression of matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for oral cancer was studied immunohistochemically. In 20 of 26 patients (76.9%) with lymph node metastases, proMMP-2 was strongly expressed, whereas the production of proMMP-2 in tissue was detected only in 5 of 20 patients (25%) who had no lymph node metastases. In tissue specimens, proMMP-2 was expressed in a diffuse invasive mode and in the advancing front of cancer. Because MMP-2 can degrade type IV collagen composed of basement membrane, these results suggest that the in vivo production of the enzyme by cancer is an indicator of the degree of malignancy, and that the analysis of proMMP-2 expression is useful to evaluate the malignant potential in individual oral squamous cell carcinoma.

journal_name

Am J Clin Pathol

authors

Kusukawa J,Sasaguri Y,Shima I,Kameyama T,Morimatsu M

doi

10.1093/ajcp/99.1.18

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

18-23

issue

1

eissn

0002-9173

issn

1943-7722

journal_volume

99

pub_type

杂志文章
  • Reporting of Benign Endometrial Cells in Papanicolaou Tests.

    abstract:OBJECTIVES:The 2014 Bethesda System (TBS 2014) guidelines for reporting cervical cytology revised the age for reporting benign endometrial cells (BECs) from 40 years or older to age 45 years or older. We evaluated this change and further investigated if extending the reporting age to 50 years or older may be acceptable...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa041

    authors: Hernandez A,Schatz-Siemers N,Zhou F,Brandler TC,Negron R,Modi L,Elgert PA,Simsir A

    更新日期:2020-08-05 00:00:00

  • Endocrinology in cancer of the breast. Status and prospects.

    abstract::Breast cancer is the result of a multistage carcinogenic process. Initiation, promotion, dependency and autonomy make up a sequence of experimentally distinguishable phases of this process. Progression--the transition from dependency on hormonal support to autonomy--is demonstrable clinically. High-affinity saturatabl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/64.6.797

    authors: Brennan MJ

    更新日期:1975-12-01 00:00:00

  • Influence of blood collection systems on the prothrombin time and international sensitivity index determined with human and rabbit thromboplastin reagents.

    abstract::Three brands of blood collection tubes were studied for their influence on the prothrombin time (PT) and international sensitivity index (ISI) for 5 commercial thromboplastin reagents. With all reagents, PTs were shorter in Vacutainer (Becton Dickinson Vacutainer Systems, Plymouth, England) samples than in S-Monovette...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/NW194EAMD4WMEHJD

    authors: van den Besselaar AM,Hoekstra MM,Witteveen E,Didden JH,van der Meer FJ

    更新日期:2007-05-01 00:00:00

  • Prevalence of non-A,non-B hepatitis/hepatitis C virus antibody in human immunoglobulins.

    abstract::Human intravenous immunoglobulins prepared by the cold ethanol fractionation technique of Cohn are considered safe with respect to infectivity. However, there have been several instances of transmission of both hepatitis B and non-A,non-B hepatitis viruses after administration of intravenous immunoglobulins. To determ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.1.108

    authors: Dodd LG,McBride JH,Gitnick GL,Howanitz PJ,Rodgerson DO

    更新日期:1992-01-01 00:00:00

  • A simple light-scattering method for detecting soluble immune complexes in human serum.

    abstract::A simple assay based on molecular light scattering was developed to detect soluble immune complexes. In this assay the percentage of relative light scattering (%RLS) caused by complexes in buffer containing polyethylene glycol 6000 (PEG) was measured with a laser nephelometer. In low concentrations of PEG (3%-5%), IgG...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.6.804

    authors: Koethe SM,Melton HE,Jendrzejczak Z

    更新日期:1980-12-01 00:00:00

  • Incidental coenurosis: larval cestode presenting as an axillary mass.

    abstract::This article describes the occurrence of a coenurus, the encysted larval stage of a cestode of the genus Multiceps, within the axilla of a 40-year-old Nigerian woman. The patient had a history of intraductal carcinoma of the breast two years prior to the finding of an ipsilateral axillary mass. Pathologic evaluation o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.5.735

    authors: Kurtycz DF,Alt B,Mack E

    更新日期:1983-11-01 00:00:00

  • Analysis of cerebrospinal fluid cells from an american child with Burkitt's Lymphoma.

    abstract::Tumor cells in the cerebrospinal fluid of an American child with Burkitt's lymphoma are described. The morphology of the cells was demonstrated better by use of the "millipore" technic and hematoxylin and eosin staining than by the Wright-stained smear. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.2.238

    authors: Fuchs HB,Rosan RC

    更新日期:1975-08-01 00:00:00

  • A comparison of immunohistochemical stain quality in conventional and rapid microwave processed tissues.

    abstract::Same-day turnaround of pathology specimens is desirable in this era of managed care, and rapid microwave tissue processing produces histologic features of a quality equivalent to overnight processing. We studied whether microwave-assisted rapid tissue processing adversely affects the quality of immunohistochemical sta...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/GN6Q-CBML-LEAT-LK2M

    authors: Emerson LL,Tripp SR,Baird BC,Layfield LJ,Rohr LR

    更新日期:2006-02-01 00:00:00

  • Radioimmunoassays for protein C and factor X. Plasma antigen levels in abnormal hemostatic states.

    abstract::Specific radioimmunoassays, sensitive to plasma levels of less than 1% of normal, were developed for protein C and Factor X. In 31 normal subjects, mean plasma antigen levels were as follows: protein C, 3.23 +/- 0.79 microgram/mL (2 SD); Factor X, 7.74 +/- 1.81 microgram/mL. In patient son chronic warfarin therapy, pr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.5.573

    authors: Epstein DJ,Bergum PW,Bajaj SP,Rapaport SI

    更新日期:1984-11-01 00:00:00

  • Postpartum hemophilia.

    abstract::An acquired circulating inhibitor to Factor VIII:C was found in a 27-year-old postpartum woman who presented with ecchymoses and hematomas. Postpartum Factor VIII:C inhibitors can clinically manifest with signs and symptoms not unlike those in a classic hemophiliac. The natural history of this inhibitor is typically o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.5.789

    authors: Shitamoto BS,Leslie KO,Galloway WB

    更新日期:1982-11-01 00:00:00

  • Evaluation of a semiautomated micro-broth dilution system for determing minimum inhibitory concentrations of antimicrobics.

    abstract::This study investigates the dispensing and inoculating characteristics of the MIC-2000 micro-broth dilution system and compares its ability to determine minimum inhibitory concentrations with that of the reference macro-broth dilution method. Micro-well filling showed a coefficient of variation of 6.8%, and micro-well...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.374

    authors: Woolfrey BF,Ramadei WA,Quall CO

    更新日期:1980-03-01 00:00:00

  • Ultrastructural examination of urinary sediment. Value in renal amyloidosis.

    abstract::Examination of urinary sediment has been recommended as a useful diagnostic aid for renal amyloidosis. This procedure was evaluated in the cases of 57 patients, including 11 with proven renal amyloidosis and 13 considered very likely to have the disease. At least three types of urinary fibrillar material were observed...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.1.36

    authors: Winer RL,Wuerker RB,Erickson JO,Cooper WL

    更新日期:1979-01-01 00:00:00

  • The expression of HLA class I antigens in germ cell testicular cancer.

    abstract::The expression of HLA class I antigens in testicular germ cell tumors (TGCTs) was studied by the immunoperoxidase technique. In the normal testicle, the interstitial cells of Leydig as well as most of the germ cells were significantly stained. In typical seminoma, 75% of the tumor cells in stage I and 30% in stage II ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.2.202

    authors: Klein B,Klein T,Konichezky M,Nyska A,Livini E,Levine I,Zamir R,Kooperman O,Lurie H

    更新日期:1990-02-01 00:00:00

  • A hemolytic plate method for alternative-pathway complement activity assay.

    abstract::A new hemolytic plate method for the functional assessment of alternative-pathway complement activity is described. The plates are easy to prepare and the method simple to perform. Analysis of 23 normal serum samples showed a mean lysis diameter of 4.1 +/- 0.2 mm (1 standard deviation). ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.2.156

    authors: Fong JS,Renaud L

    更新日期:1978-02-01 00:00:00

  • Reproducibility of mean values of duplicate specimens in the Basic Ligand Assay Survey.

    abstract::Three paired samples were distributed at three--six-month intervals in the Basic Ligand Survey during 1976. The stabilities of mean values obtained by widely used commercial kit procedures and by all methods for eight analytes are reported. Significant improvements in accuracy and long-term precision were identified i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Haven GT,Hansell JR,Haven MC

    更新日期:1978-09-01 00:00:00

  • BRAF mutation status in gastrointestinal stromal tumors.

    abstract::Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors characterized by mutations of KIT or PDGFRA. The objectives of this study were to evaluate BRAF mutations in GISTs and then to correlate BRAF mutational status in the tumor with clinical parameters, with B-raf expression, and with activation of some cellul...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPPCKGA2QGBJ1R

    authors: Hostein I,Faur N,Primois C,Boury F,Denard J,Emile JF,Bringuier PP,Scoazec JY,Coindre JM

    更新日期:2010-01-01 00:00:00

  • Evaluation of the status of laboratory practices and the need for continuing education in medical mycology.

    abstract::A survey to determine the need for training in medical mycology was sent to 605 US laboratories. Training needs were determined by comparing actual laboratory mycology practices with recommended practices, documenting the extent of mycology training reported by employees, and asking respondents to specify the fungi th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/RR95-P7DN-41LW-1LGQ

    authors: Rosner ER,Reiss E,Warren NG,Shadomy HJ,Lipman HB

    更新日期:2002-08-01 00:00:00

  • Evaluation of methods of detecting terminal deoxynucleotidyl transferase in human hematologic malignancies. Comparison of immunofluorescence and enzymatic assays.

    abstract::Terminal transferase (TdT) activity and antigen have been measured in 267 specimens of human bone marrow and peripheral blood by using a biochemical assay for enzymatic activity and an immunofluorescence test for antigen. Oligo p(dA)50 and dGTP were used as reagents in the biochemical assay and either rabbit anti-calf...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.4.420

    authors: Cibull ML,Coleman MS,Nelson O,Hutton JJ,Gordon D,Bollum FJ

    更新日期:1982-04-01 00:00:00

  • The Importance of Genetics Experts in Optimizing Genetic Test Orders Through Prospective and Retrospective Reviews.

    abstract:OBJECTIVES:To demonstrate the impact of genetics specialists on identifying test order errors and improving reimbursement for genetic testing. METHODS:Forty-four cases in which whole exome sequencing (WES) was performed but not reimbursed were reviewed by a genetic counselor through simulated prospective and retrospec...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz188

    authors: Conway ME,Kalejta CD,Sternen DL,Singh IR

    更新日期:2020-03-09 00:00:00

  • SATB2 in Neoplasms of Lung, Pancreatobiliary, and Gastrointestinal Origins.

    abstract:OBJECTIVES:Special AT-rich binding protein 2 (SATB2) immunohistochemistry (IHC) has high sensitivity and specificity for colorectal adenocarcinoma (CRC), but data on its expression in specific subsets of pulmonary, gastric, small bowel, and pancreatobiliary adenocarcinomas (ADCAs) are relatively limited or discordant. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa118

    authors: De Michele S,Remotti HE,Del Portillo A,Lagana SM,Szabolcs M,Saqi A

    更新日期:2021-01-04 00:00:00

  • Hepatosplenic gamma/delta T-cell lymphoma in immunocompromised patients. Report of two cases and review of literature.

    abstract::We describe 2 male patients in whom hepatosplenic gamma/delta T-cell lymphoma (HSTL) developed 6 and 10 years after renal transplantation. The onset was abrupt with systemic symptoms, cytopenia, and hepatosplenomegaly. The histologic examination of the spleen (case 1), liver, and bone marrow revealed sinusoidal infilt...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/TC9U-FAV7-0QBW-6DFC

    authors: Khan WA,Yu L,Eisenbrey AB,Crisan D,al Saadi A,Davis BH,Hankin RC,Mattson JC

    更新日期:2001-07-01 00:00:00

  • Hormone receptor levels and aspiration cytology in cancer of the breast.

    abstract::The cytopathologic findings of 196 cases of cancer of the breast were correlated with the hormonal receptor levels. The strict cytologic criteria that allow a positive diagnosis to be used as bases for definitive treatment include adequate cellularity, lack of cohesion, and nuclear abnormalities, including increased n...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.6.847

    authors: Kern WH

    更新日期:1982-12-01 00:00:00

  • Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. A morphometric, immunohistochemical, and ultrastructural study.

    abstract::A morphometric and immunohistochemical study was performed to assess the spleen's alterations in patients with autoimmune thrombocytopenia and in drug abusers with thrombocytopenia (DAT) related to human immunodeficiency virus (HIV) infection. A total of 34 patients were included in the study: 20 DAT patients and 14 w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.6.633

    authors: Marti M,Feliu E,Campo E,Palacin A,Berga L,Casals FJ,Urbano Ispizua A,Cardesa A,Rozman C

    更新日期:1993-12-01 00:00:00

  • Effects of storage time and exogenous protease inhibitors on plasma protein levels.

    abstract::Plasma biomarker analysis requires intact unbiased starting material. We analyzed the effects on plasma protein profiles of protease inhibitor cocktails and preprocessing storage. Plasma from 12 healthy subjects collected with and without protease inhibitors was prepared immediately and after 2 hours of room temperatu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3WM7-XJ7R-D8BC-LNKX

    authors: Ayache S,Panelli M,Marincola FM,Stroncek DF

    更新日期:2006-08-01 00:00:00

  • Extranodal lymphomas associated with hepatitis C virus infection.

    abstract::Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease (low-grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.5.600

    authors: Ascoli V,Lo Coco F,Artini M,Levrero M,Martelli M,Negro F

    更新日期:1998-05-01 00:00:00

  • The liver in celiac disease: clinical manifestations, histologic features, and response to gluten-free diet in 30 patients.

    abstract::Descriptive reports of liver histologic features in celiac disease (CD) are sparse, and the effect of a gluten-free diet (GFD) on the course of liver injury is poorly understood. We reviewed liver biopsy specimens in 30 patients with CD and performed immunostains for IgG, IgG4, IgM, and IgA. Subsequent liver biochemic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPDOMY5RI5TPMN

    authors: Mounajjed T,Oxentenko A,Shmidt E,Smyrk T

    更新日期:2011-07-01 00:00:00

  • Computer-assisted work station timing analysis of instrument labor efficiency.

    abstract::Labor use ratings assigned to instruments by the Workload Recording Method (WRM) do not change with batch size or walk-away time use. The authors evaluated the effect of both on the labor use of the analyzers Paramax B6100 (Baxter Paramax, Irvine, CA) and Ektachem 700 (Eastman Kodak, Rochester, NY) by timing all worke...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.5.743

    authors: McClellan GA,Nipper HC,Horn MJ,Burris WD,Hodges K,Monaco S,Cox RS Jr

    更新日期:1991-05-01 00:00:00

  • Immunoalkaline phosphatase cytochemistry. Technical considerations of endogenous phosphatase activity.

    abstract::The authors have developed an immunoalkaline phosphatase method and have applied it with success to the study of blood cells. They have now observed that macrophages in tissues and in serous effusions may be nonspecifically stained when immunoalkaline phosphatase methods are used. A systematic study of this endogenous...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.4.476

    authors: Janckila AJ,Yam LT,Li CY

    更新日期:1985-10-01 00:00:00

  • Pseudo-sulfur granules associated with intrauterine contraceptive devices.

    abstract::A structure resembling a sulfur granule found in histologic sections of endometrium from patients with intrauterine contraceptive devices is described. It is distinguished from a true sulfur granule on morphologic grounds and is further characterized as a foreign substance, most probably fragments of the synthetic con...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.6.822

    authors: O'Brien PK,Roth-Moyo LA,Davis BA

    更新日期:1981-06-01 00:00:00

  • Leukocyturia in cyclosporine-treated renal allograft recipients.

    abstract::Five hundred eighty-seven daily urine specimens were examined from 179 consecutive renal allograft recipients with the use of quantitative cytodiagnostic urinalysis. Specimens were divided between those patients receiving cyclosporine (CyA) and steroid immunotherapy (73 patients) and those receiving standard azathiopr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.1.113

    authors: Ashton A,Alexander DP,DeBellis C,Schumann GB

    更新日期:1988-01-01 00:00:00