Abstract:
:Five hundred eighty-seven daily urine specimens were examined from 179 consecutive renal allograft recipients with the use of quantitative cytodiagnostic urinalysis. Specimens were divided between those patients receiving cyclosporine (CyA) and steroid immunotherapy (73 patients) and those receiving standard azathioprine (Aza) and steroid immunotherapy (106 patients). When patients with urinary tract infections were excluded, an increase in leukocyturia was observed in the CyA-treated patients. Ninety-three percent of the CyA-treated patients had at least one specimen with more than 1,000 neutrophils/10 high-power fields (HPFs) versus 62% of the 106 Aza-treated patients. Sixty-four percent of the specimens examined from the CyA-treated group had more than 1,000 neutrophils/10 HPFs compared with only 18% of specimens from Aza-treated patients. It appears that CyA is a cause of sterile leukocyturia in renal allograft recipients. The significance of leukocyturia in CyA nephrotoxicity needs further definition.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Ashton A,Alexander DP,DeBellis C,Schumann GBdoi
10.1093/ajcp/89.1.113subject
Has Abstractpub_date
1988-01-01 00:00:00pages
113-7issue
1eissn
0002-9173issn
1943-7722journal_volume
89pub_type
杂志文章abstract::Dialogue regarding the autopsy has been sustained largely by medical students and professionals, and by families of deceased patients. Exclusion of the general public may represent a significant reason for the inexorable decline of autopsy rates and politicoeconomic support. Sensitivity to public concerns regarding th...
journal_title:American journal of clinical pathology
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