Abstract:
:Histiocytosis-X cells were obtained at autopsy from the lungs and lymph nodes of a patient who died of the disseminated infantile form of this disease (Letterer-Siwe disease). The ability of these cells to synthesize and release prostaglandins was investigated in culture, by prelabeling the cell lipids with [14C] arachidonic acid and measuring the subsequent release of radioactive metabolites. The cells were seen to release primarily PGD2 and thromboxane. Correlative morphologic studies ensured the purity of the cell preparations, ruling out extraneous origin of the prostaglandins from sources other than the lesional histiocytes. Electron-microscopic study confirmed that the same cells that release prostaglandins and are capable of engulfing particles also bear the Langerhans' inclusions considered to be cell markers of histiocytosis-X. The prostaglandin production profile of alveolar macrophages from an infant who died as a result of congestive heart failure, but without histiocytosis, was studied for comparison. These cells produced PGE2 and thromboxane, but not PGD2. The theoretical implications of these findings are discussed.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Gonzalez-Crussi F,Hsueh W,Wiederhold MDdoi
10.1093/ajcp/75.2.243subject
Has Abstractpub_date
1981-02-01 00:00:00pages
243-53issue
2eissn
0002-9173issn
1943-7722journal_volume
75pub_type
杂志文章abstract::Although acute myeloid leukemias (AMLs) cytochemically negative for myeloperoxidase are now well recognized, myeloid surface antigen-negative AMLs are rare. The morphologic, cytochemical, immunologic, and cytogenetic or molecular features of such cases are described in four adults aged 19 to 60 years. All had AML with...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/107.1.68
更新日期:1997-01-01 00:00:00
abstract::Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/77.3.305
更新日期:1982-03-01 00:00:00
abstract::The authors analyzed the frequency of immunophenotypic abnormalities in 1,474 cases of routinely fixed, paraffin-embedded B-lineage non-Hodgkin's lymphomas. B-lineage was determined by immunoreactivity for CD20 (L26, 92%); CD45RA (4KB5, an additional 3%) or immunoglobulin (Ig) light chain restriction (remaining 5%). C...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/102.6.825
更新日期:1994-12-01 00:00:00
abstract::A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/87.4.518
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVES:B-lymphoblastic leukemia (B-LBL) arising in patients with chronic lymphocytic leukemia (CLL) is exceedingly rare and poorly characterized. METHODS:We describe four patients with CLL and concurrent or subsequent B-LBL diagnosed by morphologic, immunophenotypic, cytogenetic, and molecular analysis and reviewe...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPXE5VMONMVLZ0
更新日期:2015-08-01 00:00:00
abstract::Two radioimmunoassay procedures (RIA-1 and RIA-2) were evaluated for the quantitation of prostatic acid phosphatase in serum and compared with the enzymatic method and counter immunoelectrophoresis method for their specificity and sensitivity. Sera from 168 patients were analyzed and these included: normals, 27; untre...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/76.4.430
更新日期:1981-10-01 00:00:00
abstract::The greater precision in prothrombin time monitoring obtained using thromboplastins with low international sensitivity index (ISI) values are believed to result in improved patient care. The authors conducted a blinded prospective study of 84 random patients on low-intensity warfarin therapy who were monitored with ei...
journal_title:American journal of clinical pathology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajcp/102.1.134
更新日期:1994-07-01 00:00:00
abstract::A man was hospitalized with bacteremic Achromobacter xylosoxidans type IIIa pneumonia. The authors are aware of no previously reported similar infections caused by this bacterium. A clinical cure was achieved with a combination of carbenicillin and kanamycin therapy. Microtiter susceptibility testing revealed that car...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/70.4.712
更新日期:1978-10-01 00:00:00
abstract::Criteria for assessing adequacy of cervicovaginal smears according to the Bethesda System include cellular composition and quantity, specimen preservation, fixation, and absence of obscuring elements. The reproducibility of adequacy assessment using these parameters was the focus of this study. Specimens were chosen t...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/102.3.354
更新日期:1994-09-01 00:00:00
abstract::A case of metastatic squamous cell carcinoma to bone was studied using immunoperoxidase methods for Factor VIII-related antigen, producing positive staining in the tumor cells. Electron microscopy proved the squamous nature of the tumor, and, subsequently, a pulmonary primary tumor was found. Testing of additional tum...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.1.117
更新日期:1984-01-01 00:00:00
abstract::Although cytology laboratories are mandated to rescreen at least 10% of cervicovaginal smears, there is no uniform national rescreening practice. Follow-up data for 16,188 rescreened cervicovaginal smears were studied and decision analysis was performed to determine an optimal rescreening strategy. High-grade dysplasi...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/111.5.601
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:The metaplastic intestinal epithelium in Barrett esophagus (BE) occasionally contains Paneth cells; however, little is known regarding the prevalence and significance of Paneth cell metaplasia (PCM) in BE. METHODS:We evaluated 757 esophageal biopsy specimens with intestinal metaplasia (IM) for PCM. Outcome ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPVUJMCVBC9PKM
更新日期:2015-05-01 00:00:00
abstract::Although the hematopoietic origin of mast cells is very probable, the cell from which they originate is still a matter of speculation. The description of "transitional basophil/mast cells" in myeloproliferative disorders has suggested a common origin for basophils and mast cells. In a case of mast cell transformation ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/86.2.212
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVES:To investigate the clinicopathologic features of extranodal natural killer/T-cell lymphoma (ENKTL) not preceded by another Epstein-Barr virus (EBV)-related disorder in children and adolescents. METHODS:A series of 17 cases of ENKTL not preceded by another EBV-related disorder in children and adolescents in ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqv010
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous disorder defined by morphologic, genetic, or clinical features. Genetic abnormalities associated with AML-MRC are often associated with adverse prognostic features, and many cases are preceded by a myelodysplastic syndrom...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCP58RSMFRHLHHH
更新日期:2015-07-01 00:00:00
abstract::We conducted this study to ascertain the prevalence of erb-b2 gene amplification in breast cancer specimens read as 2+ in immunohistochemical analysis. Slides from patients with metastatic or recurrent breast cancer were eligible for fluorescent in situ hybridization (FISH) study if they were read as 2+ immunohistoche...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/R2X4KK22QCL7PLME
更新日期:2005-07-01 00:00:00
abstract::The availability of automated anti-Xa heparin assays provides the opportunity to manage patient unfractionated heparin levels directly, rather than by the activated partial thromboplastin time. Because critically ill patients can acquire an antithrombin deficiency, we compared the performance of 3 anti-Xa heparin assa...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/8E3U7RXEPXNP27R7
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To evaluate cryoprecipitate and platelet ordering practices after the implementation of real-time clinical decision support systems (CDSSs) in a computerized physician order entry (CPOE) system. METHODS:Uniform platelet and cryoprecipitate transfusion thresholds were implemented at 11 hospitals in a regiona...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1309/AJCP1OSRTPUJE9XS
更新日期:2014-01-01 00:00:00
abstract::The quality management program in the Division of Transfusion Medicine at our institution had evolved to the point that the program generally was perceived to be the sole responsibility of our Quality Unit (which was administratively independent of day-to-day operations). It became clear that this administrative model...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/UHKMFRFTDRJ7MJ58
更新日期:2005-10-01 00:00:00
abstract::Counterimmunoelectrophoresis was used to detect Cryptococcus neoformans capsular polysaccharide in the body fluids of infected patients. Using rabbit anti-C. neoformans A15 globulin, counterimmunoelectrophoresis detected 1.25 microgram of purified cryptococcal polysaccharide per ml of cerebrospinal fluid (CSF) or urin...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/68.1.39
更新日期:1977-07-01 00:00:00
abstract::A case of signet ring cell lymphoma, a rare variant of follicular center cell lymphoma, is presented with a review of 20 other such lymphomas previously reported in the English literature. The histologic, immunocytologic, and electron microscopic features are described with speculation as to the possible relationship ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.3.358
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS:We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPS88CMJRXZBWA
更新日期:2014-06-01 00:00:00
abstract::A 63-year-old white man had simultaneous onset of the Guillain-Barré syndrome and the nephrotic syndrome, three weeks after having an upper respiratory tract infection. Many granular casts were noticed in the urine sediment. Renal biopsy specimens showed early membranous glomerulonephritis and acute interstitial nephr...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/78.4.563
更新日期:1982-10-01 00:00:00
abstract::During a three-year period, Staphylococcus aureus and Pseudomonas aeruginosa were the organisms most commonly isolated from blood cultures of burned children. Microorganisms were considered to contribute to the cause of death in 17 of 20 patients who died from various complications of thermal injuries. Pseudomonas aer...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/63.4.502
更新日期:1975-04-01 00:00:00
abstract::A practical acidimetric assay for penicillinase production using penicillin and phenol red impregnated in paper discs was developed. Blank discs were first impregnated with buffered penicillin G and, after drying, with 1% phenol red. For use, a disc was added to a bacterial suspension made in saline solution. A yellow...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/75.4.557
更新日期:1981-04-01 00:00:00
abstract::Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/105.5.544
更新日期:1996-05-01 00:00:00
abstract::Fresh frozen plasma (FFP) normally requires about 45 min to thaw in a 37 degrees C water bath when placed inside an additional plastic overbag. That relatively prolonged time may result in non-utilization or delays in delivery of the product, especially, during emergency surgery. One report recommends the use of a mic...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/78.2.220
更新日期:1982-08-01 00:00:00
abstract::We assessed the Sysmex UF-50 for reproducibility of results and carryover rate by performing between- and within-run precision analyses on 315 urine samples, evaluated the feasibility of using the UF-50 to measure urinary cellular and noncellular components by comparing results from the UF-50 with results of manual ur...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/RT7X-EMGF-G8AV-TGJ8
更新日期:2001-04-01 00:00:00
abstract::Data from the 1978 CAP Hematology Survey were analyzed for the effect of sodium and calcium salts of heparin on the activated partial thromboplastin time (APTT). The results indicate that the sodium salt of heparin prolongs the APTT more than the calcium salt at a heparin concentration of 0.2 units/ml. Furthermore, th...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::Campylobacter medium (CAMPY, Becton Dickinson [BD] Microbiology Systems, Cockeysville, MD) and Vancomycin Screen Agar (VSA, BD) were compared for their ability to screen for vancomycin-resistant Enterococcus (VRE) from primary plates. A microdilution minimal inhibitory concentration (MIC) assay (Pasco, BD) served as t...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/TWY5-04QE-9KV0-52MT
更新日期:2002-01-01 00:00:00