Endometrial stromal sarcomas: immunoprofile with emphasis on HMB45 reactivity.

Abstract:

OBJECTIVES:We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS:We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and leiomyosarcoma were excluded from the study. Data from the Surveillance Epidemiology and End Results program on low- and high-grade ESS for 1973 through 2003 were obtained. RESULTS:One uterine primary ESS had collections of clear cells (20%), while a metastatic ESS contained predominantly clear cells (90%). CD10 (88.2%) and smooth muscle actin (70.5%) were the most common positive immunohistochemical markers. The latter marker was located in the cytoplasm in 47% of the ESS and in the nucleus in 23.5%, a previously unreported feature. HMB45 was detected in 23.5% of the ESS, which contrasts with the 2% reported by other authors. CONCLUSIONS:The presence of clear cells and HMB45 reactivity does not justify the term perivascular epithelioid cell tumors for these neoplasms. Two of 17 patients with ESS died of metastatic disease. However, among 274 cases of ESS (all stages included) collected by the Surveillance Epidemiology and End Results Program of the National Cancer Institute during a 30-year period, the 10-year survival rate was 94%.

journal_name

Am J Clin Pathol

authors

Albores-Saavedra J,Dorantes-Heredia R,Chablé-Montero F,Chanona-Vilchis J,Pérez-Montiel D,Lino-Silva LS,González-Romo MA,Ramírez-Jaramillo JM,Henson DE

doi

10.1309/AJCPS88CMJRXZBWA

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

850-5

issue

6

eissn

0002-9173

issn

1943-7722

pii

AJCPS88CMJRXZBWA

journal_volume

141

pub_type

杂志文章
  • Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis. A report of 27 cases.

    abstract::Kikuchi's lymphadenitis is a self-limiting condition typically affecting young patients. Surgical biopsy is unnecessary if a firm diagnosis can be rendered by fine-needle aspiration cytology (FNAC). The authors report the FNAC findings for 27 cases, including 24 female and 3 male patients aged 12 to 43 years. Histolog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.4.454

    authors: Tsang WY,Chan JK

    更新日期:1994-10-01 00:00:00

  • Advantages of a new anticoagulant in routine hematology on the Coulter Counter S-Plus STKR analyzer.

    abstract::The authors report the advantages of a new anticoagulant-antiaggregant mixture that avoids the deleterious effects of ethylenediaminotetraacetic acid (EDTA) on mean platelet volume and also prevents EDTA-induced platelet clumping. It is suitable for routine cell counting and sizing with the Coulter Counter S-Plus STKR...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.6.760

    authors: Lippi U,Schinella M,Modena N,Nicoli M,Lippi G

    更新日期:1990-06-01 00:00:00

  • Positive direct antiglobulin test and high serum immunoglobulin G values.

    abstract::To investigate the association between the positive direct antiglobulin test (DAT) and hypergammaglobulinemia, the authors prospectively studied 154 patients, classified into three groups: Group 1, 52 patients with a positive DAT result in pretransfusion samples; Group 2, 52 patients with a negative DAT result; and Gr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.2.197

    authors: Huh YO,Liu FJ,Rogge K,Chakrabarty L,Lichtiger B

    更新日期:1988-08-01 00:00:00

  • Mucocele-like tumors of the breast. Cytologic findings in two cases.

    abstract::Mucocele-like tumors of the breast originally were reported by Rosen in 1986 as benign lesions that histologically resembled colloid carcinoma of the breast. The authors document two cases of mucocele-like tumors to illustrate the difficulty in separating these lesions from colloid carcinoma on the basis of fine-needl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.6.875

    authors: Bhargava V,Miller TR,Cohen MB

    更新日期:1991-06-01 00:00:00

  • A side-by-side evaluation of four platelet-counting instruments.

    abstract::The performances of four instruments for counting platelets were evaluated in a side-by-side study: the Haema-Count MK-4/HC, an electronic impedance instrument that counts platelets in platelet-rich plasma; the Ultra-Flo 100, and the Coulter Counter Model S-Plus, electronic impedance instruments that count platelets i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.2.119

    authors: Dalton WT Jr,Bollinger P,Drewinko B

    更新日期:1980-08-01 00:00:00

  • Performance characteristics of nested polymerase chain reaction vs real-time polymerase chain reaction methods for detecting Mycobacterium tuberculosis complex in paraffin-embedded human tissues.

    abstract:OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP2QZRH4ZNPRDD

    authors: Seo AN,Park HJ,Lee HS,Park JO,Chang HE,Nam KH,Choe G,Park KU

    更新日期:2014-09-01 00:00:00

  • Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H.

    abstract::The role of viruses in several renal diseases is not documented clearly. The authors attempted to localize envelope glycoproteins of Hantaan virus in biopsy specimens from patients with Korean hemorrhagic fever (KHF) as evidence of direct viral invasion of renal tissues. The authors studied sequential sections of kidn...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.398

    authors: Kim S,Kang ET,Kim YG,Han JS,Lee JS,Kim YI,Hall WC,Dalrymple JM,Peters CJ

    更新日期:1993-10-01 00:00:00

  • The role of automated measurement of RBC subpopulations in differential diagnosis of microcytic anemia and β-thalassemia screening.

    abstract::Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement of RBC subpopulations is now available on the Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe the new formulas: % microcytic - % hypochromic; and % microcytic - % hypochromic - red cell distributio...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPJRH1I0XTNFGA

    authors: Urrechaga E,Borque L,Escanero JF

    更新日期:2011-03-01 00:00:00

  • The partial thromboplastin time in the CAP survey program.

    abstract::Analysis of the data for the 1969 to 1973 CAP Surveys of proficiency in partial thromboplastin time (PTT) determination indicates more than desirable variability in this measurement. Non-activated procedures show greater interlaboratory variability than activated methods; therefore, they may be preferable for routine ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Koepke JA

    更新日期:1975-06-01 00:00:00

  • Fluorescent cytochemical detection of estrogen and progesterone receptors in breast fine-needle aspirates.

    abstract::Estrogen and progesterone receptors were studied in fine-needle aspiration biopsy specimens of 56 patients with primary, recurrent, or metastatic breast carcinoma. The ligands, 17 B-estradiol-6-carboxymethyloxine-bovine serum albumin fluorescein isothiocyanate (FITC-BSA estradiol) and hydroxyprogesterone hemisuccinate...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.1.35

    authors: Masood S

    更新日期:1991-01-01 00:00:00

  • Lipocortin-1 immunoreactivity in the normal human central nervous system and lesions with astrocytosis.

    abstract::The authors have examined the cellular distribution of lipocortin-1 (L-1) in the normal and diseased central nervous system (CNS) using the peroxidase-antiperoxidase (PAP) technique with a polyclonal antibody specific for L-1. L-1 immunoreactivity was evaluated in the frontal cortex, parahippocampal gyrus/lateral vent...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.4.424

    authors: Johnson MD,Kamso-Pratt JM,Whetsell WO Jr,Pepinsky RB

    更新日期:1989-10-01 00:00:00

  • Lack of in vitro interaction between heparin and nitroglycerin.

    abstract::Nitroglycerin has been reported to reduce activated partial thromboplastin time (aPTT) values in patients treated with concurrent heparin and nitroglycerin. However, in vivo studies have yielded conflicting results. In this in vitro evaluation, nitroglycerin was added to samples of pooled plasma from normal volunteers...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.3.298

    authors: Barnes AD,Horn JR,Wittkowsky AK

    更新日期:1996-03-01 00:00:00

  • Clinical trial of a new disposable bleeding-time device.

    abstract::A new disposable bleeding time device (Hemalet) was tested in 20 normal individuals and 11 patients with various bleeding disorders. The results were compared with those of Simplate II. The mean bleeding time for normal individuals was 5.4 +/- 1.5 (mean +/- 1 SD) minutes by Hemalet and 5.8 +/- 1.4 (mean +/- 1 SD) minu...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1093/ajcp/85.5.610

    authors: Toomey KC,Kim HC,Kosmin M,Saidi P

    更新日期:1986-05-01 00:00:00

  • Antimicrobial resistance in Haemophilus isolates: a Minnesota experience and literature review.

    abstract::Annual ampicillin susceptibility rates for Haemophilus influenzae isolates at the St. Paul-Ramsey Medical Center gradually decreased from 100% in 1974 to 83.3% in 1980 and then remained stable at 88.90%. Penicillin susceptibility rates were similar to those for ampicillin. Ampicillin rates were source dependent: eye 9...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.3.311

    authors: Woolfrey BF,Lally RT,Ireland GK,Quall CO,Ederer MN

    更新日期:1984-09-01 00:00:00

  • ABH blood group isoantigen expression in breast carcinomas--an immunohistochemical evaluation using monoclonal antibodies.

    abstract::The ABH blood group isoantigen status of a retrospective series of 233 invasive breast carcinomas was examined, employing monoclonal antibodies (MCAB) against A, B, and H antigens with the avidin-biotin-peroxidase complex method. In addition, the H antigen was localized with Ulex Europeus Agglutinin I (UEAI) binding. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/83.3.308

    authors: Lee AK,DeLellis RA,Rosen PP,Saigo PE,Gangi MD,Bagin R,Groshen S,Wolfe HJ

    更新日期:1985-03-01 00:00:00

  • Linking Statistics With Testing Policy to Manage COVID-19 in the Community.

    abstract:OBJECTIVES:To determine the public health surveillance severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing volume needed, both for acute infection and seroprevalence. METHODS:Required testing volumes were developed using standard statistical methods based on test analytical performance, disease preval...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa099

    authors: Hilborne LH,Wagner Z,Cabreros I,Brook RH

    更新日期:2020-07-07 00:00:00

  • Humoral and cellular studies of eosinophils in reactive and myeloproliferative syndromes with marked eosinophilia.

    abstract::In five patients with eosinophilia and myeloproliferative disorders, the IgE levels were normal, and immune complexes were not detected. In contrast, in six patients with reactive eosinophilia accompanying immunologic diseases, the IgE levels were elevated in five, and immune complexes were elevated in two. Five of si...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.3.301

    authors: Crowley JP,Myers TJ

    更新日期:1983-03-01 00:00:00

  • Diagnostic utility of carboxyl-terminal and intact parathyroid hormone immunoassays in hospitalized patients.

    abstract::In a university-affiliated community hospital, medical records of 58 patients on whom the intact parathyroid hormone immunoassay (I-PTH) and 29 patients on whom both the carboxyl terminal PTH(C-PTH) and I-PTH ordered by physicians were reviewed to determine the reasons for requesting these tests. Reasons for ordering ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.6.720

    authors: Juan D,Wehrmeister J

    更新日期:1982-06-01 00:00:00

  • Evaluation of a semiautomated micro-broth dilution system for determing minimum inhibitory concentrations of antimicrobics.

    abstract::This study investigates the dispensing and inoculating characteristics of the MIC-2000 micro-broth dilution system and compares its ability to determine minimum inhibitory concentrations with that of the reference macro-broth dilution method. Micro-well filling showed a coefficient of variation of 6.8%, and micro-well...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.374

    authors: Woolfrey BF,Ramadei WA,Quall CO

    更新日期:1980-03-01 00:00:00

  • Clinical and economic performance criteria for intraarterial and extraarterial blood gas monitors, with comparison with in vitro testing.

    abstract::The frequency with which blood gas measurements should be obtained is controversial because laboratory-based blood gas analyzers impose blood loss, delay, and cost on each measurement. Point-of-care analyzers eliminate the delay factor, but blood loss and cost factors remain. Optode microsensing can be adopted readily...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Shapiro BA

    更新日期:1995-10-01 00:00:00

  • Factitious biochemical measurements resulting from hematologic conditions.

    abstract::Factitious laboratory results often lead to unnecessary testing or treatment. This brief review of factitious biochemical results due to preexisting hematologic conditions focuses on the mechanisms underlying the factitious results and suggests ways to prevent them. An observant pathologist identifies these errors, in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPY9RP5QYTYFWC

    authors: Dalal BI,Brigden ML

    更新日期:2009-02-01 00:00:00

  • A primer on the cost of quality for improvement of laboratory and pathology specimen processes.

    abstract::In today's environment, many laboratories and pathology practices are challenged to maintain or increase their quality while simultaneously lowering their overall costs. The cost of improving specimen processes is related to quality, and we demonstrate that actual costs can be reduced by designing "quality at the sour...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPSMQYAF6X1HUT

    authors: Carlson RO,Amirahmadi F,Hernandez JS

    更新日期:2012-09-01 00:00:00

  • Some statistical implications of rounding in the College of American Pathologists Survey.

    abstract::Quantitative measurements of constituent concentrations of Survey specimens are generally recorded to the nearest integer or to the nearest tenth. Questions have arisen as to whether this degree of rounding of measurements is appropriate when available laboratory equipment can determine results more precisely. Statist...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Williams GW,Schork MA

    更新日期:1976-07-01 00:00:00

  • Restriction fragment length polymorphism and polymerase chain reaction: HLA-DQA1 and polymarker analysis of blood samples from transfusion recipients.

    abstract::The effect of blood transfusion on DNA profiles of an individual is a significant issue in the forensic context. In the present study, the effects of blood transfusion in 5 recipients were studied by performing restriction fragment length polymorphism and polymerase chain reaction HLA-DQA1 and Polymarker (LDLR, GYPA, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/KAWA-QHBU-6D1J-XY3G

    authors: Giroti RI,Biswas R,Mukherjee K

    更新日期:2002-09-01 00:00:00

  • Squamous metaplasia of the prostate. An immunohistochemical study.

    abstract::Immunoperoxidase strains for prostate-specific antigen (PSA), prostatic acid phosphatase (PAcP), epithelial membrane antigen (EMA), and cytokeratins (MAK 6 and CK-KES) were performed on 1 case of squamous cell carcinoma of the prostate and on 13 cases of squamous metaplasia of prostatic epithelium in an effort to demo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.5.597

    authors: Lager DJ,Goeken JA,Kemp JD,Robinson RA

    更新日期:1988-11-01 00:00:00

  • Lupus erythematosus cell preparation-antinuclear factor incongruity. A review of diagnostic tests for systemic lupus erythematosus.

    abstract::The cases of 20 patients, each of whom has a positive lupus erythematosus cell preparation and a negative antinuclear factor test, are presented. The concept of a false-positive lupus erythematosus preparation is suggested. Five common mechanisms causing a false-negative antinuclear factor test are discussed and evalu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.3.495

    authors: Koller SR,Johnston CL Jr,Moncure CW

    更新日期:1976-09-01 00:00:00

  • Secondary CD5+ diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter syndrome).

    abstract::Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression durin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP58FETFGLCKKW

    authors: Maeshima AM,Taniguchi H,Nomoto J,Maruyama D,Kim SW,Watanabe T,Kobayashi Y,Tobinai K,Matsuno Y

    更新日期:2009-03-01 00:00:00

  • Marrow biopsy and survival in multiple myeloma.

    abstract::Pretreatment posterior iliac crest bone marrow biopsies were obtained from 26 multiple myeloma patients. Biopsies were processed in methacrylate. The percentage of myeloma tissue, myeloid tissue, and fat was estimated in each biopsy. In 20 patients who died there was a positive correlation between the percent of myelo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.3.363

    authors: Mahmoud LA,Block MH,Franks JJ,Sayed NM

    更新日期:1983-09-01 00:00:00

  • Multicentric osteosarcoma: clinicopathologic and radiographic study of 56 cases.

    abstract::Multicentric osteosarcoma (M-OGS) is characterized by multicentricity of osseous osteosarcomas, either synchronous or metachronous, without visceral involvement. The study's purpose was to clinicopathologically and radiographically analyze 56 cases of M-OGS (22 synchronous and 34 metachronous). The distal femur was th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP0V0OATKCNAZP

    authors: Corradi D,Wenger DE,Bertoni F,Bacchini P,Bosio S,Goldoni M,Unni KK,Sim FH,Inwards CY

    更新日期:2011-11-01 00:00:00

  • Comparison of the sensitivity of commercial APTT reagents in the detection of mild coagulopathies.

    abstract::This study was undertaken to evaluate the precision and sensitivity of three different commercial APTT reagents containing the activators kaolin, micronized silica, or ellagic acid. These reagents varied greatly in their ability to detect mild coagulopathies. The ellagic acid reagent was able to detect the mildest def...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.4.436

    authors: Marlar RA,Bauer PJ,Endres-Brooks JL,Montgomery RR,Miller CM,Schanen MM

    更新日期:1984-10-01 00:00:00