Microcystic adenomas of the pancreas. Report of three cases with two of multicentric origin.

Abstract:

:Three cases of microcystic adenomas of the pancreas with special reference to multicentric origin are described. The gross features and light microscopic findings were consistent with those described as being microcystic adenomas, but in two cases the gross examination and gelatin-embedded giant slices revealed multiple, isolated development of tumors ranging from submacroscopic nodules to tumors 4.5 cm in diameter. The larger tumors often showed ragged margins with small satellite nodules around the masses. A central fibrolamellar stellate core with centrifugally radiating septation was found in most of the tumor masses, even in the smaller ones. Ultrastructural and immunohistochemical findings revealed a single row of glycogen-rich epithelial cells, but participation of myoepithelial cells was not confirmed. Instead, vimentin-positive cells (pericytes) within the interstitial space incorporated closely with the basal lamina of the cyst wall. This study suggests that a small percentage of microcystic adenomas of the pancreas develop in multiple tumors, and some appear as a single tumor by their confluence.

journal_name

Am J Clin Pathol

authors

Kim YI,Seo JW,Suh JS,Lee KU,Choe KJ

doi

10.1093/ajcp/94.2.150

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

150-6

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

94

pub_type

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