Interleukin-2 and interferon-gamma production in follicular lymphomas.


:In situ hybridization with specific RNA radiolabeled probes was used to analyze the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by 21 low-grade follicular lymphomas (FLs). All of the 21 FLs tested contained lymphokine-synthesizing cells in the interfollicular and follicular areas. Enumeration of lymphokine synthesizing cells indicated heterogeneous IL-2 production among lymph nodes tested; 2 of the 21 had much higher densities of IL-2-producing cells (855 and 570/cm2) than did the remaining 19 (mean, 92 +/- 15/cm2). IFN-gamma-producing cells displayed no such variation (mean, 77 +/- 8 IFN-gamma-producing cells/cm2). The mean IL-2/IFN-gamma-producing cell ratio was 2.69 +/- 0.84, indicating preferential induction of IL-2. The detailed distribution of lymphokine-producing cells showed that IL-2 and IFN-gamma-producing cells were located mainly in the follicular areas. The mean follicular/interfollicular ratio was 1.82 +/- 0.16 for IL-2 and 1.92 +/- 0.19 for IFN-gamma-producing cells. The results show that T-cell activation, defined by lymphokine production, occurs in FL lymph nodes in direct contact with malignant B cells. Thus, lymphokine production may play an important role in the control of tumor growth, which is the result of interaction between tumor cells and host-derived immune reaction.


Am J Clin Pathol


Peuchmaur M,Emilie D,Crevon MC,Brousse N,Gaulard P,D'Agay MF,Galanaud P,Solal-Celigny P




Has Abstract


1991-01-01 00:00:00












  • Transfusion significance of Lewis system antibodies. Success in transfusion with crossmatch-compatible blood.

    abstract::Patients with nonhemolytic Lewis antibodies in the serum were transfused on the basis of major crossmatch compatibility alone. No adverse clinical affects were noted when 33 such patients received a total of 230 transfusions. Considerable savings in technologist time and reagent cost were realized by adopting this pol...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Waheed A,Kennedy MS,Gerhan S,Senhauser DA

    更新日期:1981-09-01 00:00:00

  • The use of monoclonal antibody 44-3A6 in cell blocks in the diagnosis of lung carcinoma, carcinomas metastatic to lung and pleura, and pleural malignant mesothelioma.

    abstract::Monoclonal antibody (MoAb) 44-3A6 recognizes a glandular differentiation-associated antigen and has been used to identify exocrine differentiation in pulmonary carcinomas. The authors assessed its value in the diagnosis of lung carcinomas metastatic to lung/pleura and pleural malignant mesothelioma (MM), using cell bl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Spagnolo DV,Whitaker D,Carrello S,Radosevich JA,Rosen ST,Gould VE

    更新日期:1991-03-01 00:00:00

  • Colonic spirochetosis in children and adults.

    abstract::We undertook a retrospective analysis of colonic spirochetosis in 14 cases: females, 3; males, 11; children, 4; adults, 10. Two men had HIV infections. All children and both HIV-infected men had abdominal complaints, diarrhea, or both. Most other adults underwent colonoscopy for polyp screening (n = 4) or follow-up of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Koteish A,Kannangai R,Abraham SC,Torbenson M

    更新日期:2003-12-01 00:00:00

  • A hemolytic plate method for alternative-pathway complement activity assay.

    abstract::A new hemolytic plate method for the functional assessment of alternative-pathway complement activity is described. The plates are easy to prepare and the method simple to perform. Analysis of 23 normal serum samples showed a mean lysis diameter of 4.1 +/- 0.2 mm (1 standard deviation). ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Fong JS,Renaud L

    更新日期:1978-02-01 00:00:00

  • Marrow biopsy and survival in multiple myeloma.

    abstract::Pretreatment posterior iliac crest bone marrow biopsies were obtained from 26 multiple myeloma patients. Biopsies were processed in methacrylate. The percentage of myeloma tissue, myeloid tissue, and fat was estimated in each biopsy. In 20 patients who died there was a positive correlation between the percent of myelo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Mahmoud LA,Block MH,Franks JJ,Sayed NM

    更新日期:1983-09-01 00:00:00

  • A rapid point-of-care cardiac marker testing strategy facilitates the rapid diagnosis and management of chest pain patients in the emergency department.

    abstract::We compared a rapid, point-of-care multimarker protocol with a single and serial troponin I (TnI)-only protocol in 5,244 patients admitted to the emergency department with chest pain. The diagnosis of acute myocardial infarction (AMI) was based on a doubling myoglobin level accompanied by at least a 50% increase in th...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Straface AL,Myers JH,Kirchick HJ,Blick KE

    更新日期:2008-05-01 00:00:00

  • Frequency, Clinicopathologic Characteristics, and Follow-up of HER2-Positive Nonpleomorphic Invasive Lobular Carcinoma of the Breast.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Zhang H,Moisini I,Ajabnoor RM,Turner BM,D'aguiar M,Cai X,Gao S,Yang Q,Wang X,Schiffhauer L,Hicks DG

    更新日期:2020-04-15 00:00:00

  • Incidental coenurosis: larval cestode presenting as an axillary mass.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Kurtycz DF,Alt B,Mack E

    更新日期:1983-11-01 00:00:00

  • Catalase-negative listeria monocytogenes causing meningitis in an adult. Clinical and laboratory features.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Swartz MA,Welch DF,Narayanan RP,Greenfield RA

    更新日期:1991-07-01 00:00:00

  • Acute hepatitis with periportal confluent necrosis associated with human herpesvirus 6 infection in liver transplant patients.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Buyse S,Roque-Afonso AM,Vaghefi P,Gigou M,Dussaix E,Duclos-Vallée JC,Samuel D,Guettier C

    更新日期:2013-09-01 00:00:00

  • Factors affecting urinary myoglobin stability in vitro.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Chen-Levy Z,Wener MH,Toivola B,Daum P,Reyes M,Fine JS

    更新日期:2005-03-01 00:00:00

  • Single-dose tetracycline labeling for bone histomorphometry.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Sherrard DJ,Maloney NA

    更新日期:1989-06-01 00:00:00

  • Morphonuclear relationship between prostatic intraepithelial neoplasia and cancers as assessed by digital cell image analysis.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

    更新日期:1991-11-01 00:00:00

  • How to Teach Laboratory Stewardship in the Undergraduate Medical Curriculum?

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Winquist AG,Orrico MA,Peterson LR

    更新日期:1997-11-01 00:00:00

  • Adenovirus in the gastrointestinal tracts of immunosuppressed patients.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Strickler JG,Singleton TP,Copenhaver CM,Erice A,Snover DC

    更新日期:1992-04-01 00:00:00

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Suh-Lailam BB,Procter M,Krautscheid P,Haas J,Kumar S,Mao R,Grenache DG

    更新日期:2014-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Gaitonde S,Hassan M,Mehta V,Benedetti E,Tzvetanov I,Lichvar A,Pirzada S,Setty S

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    authors: Losito R,Beaudry P,Valderrama JC,Cousineau L,Longpré B

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  • Her2/neu Status Determination in Breast Cancer: A Single Institutional Experience Using a Dual-Testing Approach With Immunohistochemistry and Fluorescence In Situ Hybridization.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Noel LH,Droz D,Ganeval D

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    pub_type: 杂志文章


    authors: Wang E,Boswell E,Siddiqi I,Lu CM,Sebastian S,Rehder C,Huang Q

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Farhi DC,Ashfaq R

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Saad RS,Ismiil N,Dubé V,Nofech-Mozes S,Khalifa MA

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Lawson NS,Haven GT,DiSilvio TV,Gilmore BF

    更新日期:1982-10-01 00:00:00

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Brien WF,Baskerville JC,Taberner DA,Crawford L

    更新日期:1999-02-01 00:00:00

  • Breast carcinoma simulating fibroadenoma or fibrocystic change by fine-needle aspiration. A study of 16 cases.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Rogers LA,Lee KR

    更新日期:1992-08-01 00:00:00

  • Fluorescent cytochemical detection of estrogen and progesterone receptors in breast fine-needle aspirates.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Masood S

    更新日期:1991-01-01 00:00:00