Clinical Significance of Isolated Myeloperoxidase Expression in Pediatric B-Lymphoblastic Leukemia.

Abstract:

Objectives:Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence of B-lineage and absence of specific myeloid or T-lineage markers. Rare cases of otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an absence of other myeloid markers, but the clinical significance of this finding is not well studied. Methods:A retrospective cohort analysis of flow cytometry and clinical data was performed to investigate the clinical outcome of this specific group of patients. Results:Twenty-nine cases of otherwise typical B-ALL that expressed MPO by flow cytometry (B-ALL-isoMPO) without expression of other myeloid markers were identified. The B-ALL-isoMPO group had a significantly increased incidence of relapse (univariate log rank P  = .0083; multivariate hazard ratio, 2.50; 95% confidence interval, 1.07-5.85; P  = .034) and significantly worse event-free survival by univariate analysis (log rank P  = .0066) compared with a reference group of patients with B-ALL from the same time period (n = 264). Conclusions:To our knowledge, this is the first report to document the clinical outcomes in a group of pediatric patients with B-ALL that expresses MPO in the absence of other myeloid markers. This group had an increased rate of relapse and a worse event-free survival than the patients with B-ALL who did not express MPO.

journal_name

Am J Clin Pathol

authors

Oberley MJ,Li S,Orgel E,Phei Wee C,Hagiya A,O'Gorman MRG

doi

10.1093/ajcp/aqx021

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

374-381

issue

4

eissn

0002-9173

issn

1943-7722

pii

3072224

journal_volume

147

pub_type

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