Abstract:
:The authors report here a case of lymphoepithelial cystic lesion (LECL) of unknown origin in the mediastinum, which is closely related to a signet-ring cell adenocarcinoma. A 73-year-old man presented with a mass as revealed on a chest x-ray. During surgical operation, a solid, well-circumscribed and encapsulated 9 X 9 X 8 cm tumor was isolated from the right anterior mediastinum. This tumor had neither undergone metastasis nor invaded into the surrounding tissue and lymph nodes. Light microscopy revealed the tumor to be a signet-ring cell adenocarcinoma. Clinically, the neoplasm was coupled with an elevation in serum CEA level, which promptly returned to normal values following surgical removal. Immunohistochemistry pointed out that the majority of neoplastic cells stained positive for CEA. In addition, LECL of unknown origin was distinguished at the periphery of the tumor. LECL was characterized by microcysts which were lined by columnar epithelial and surrounded by lymphoid tissue with germinal centers. Transition between the neoplastic cells and benign epithelial cells of LECL was evident, showing that the previously mentioned mediastinal adenocarcinoma may be derived from the epithelial elements of LECL. This paper discusses the histogenesis of LECL.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Ishimaru Y,Shibata Y,Ohkawara S,Ohshima H,Kihara Sdoi
10.1093/ajcp/92.6.808subject
Has Abstractpub_date
1989-12-01 00:00:00pages
808-13issue
6eissn
0002-9173issn
1943-7722journal_volume
92pub_type
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1983-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2011-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1988-03-01 00:00:00