Abstract:
:We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Primary and metastatic ACCs were cytologically similar and showed a wide range of features varying from well-differentiated tumor resembling a benign cortical lesion or low-grade neuroendocrine tumor to poorly differentiated pleomorphic tumor mimicking poorly differentiated carcinoma, melanoma, or high-grade sarcoma. The common cytologic features were hypercellularity (70% of cases), necrotic debris in the background (70%), moderate to marked nuclear pleomorphism (80%), mitotic figures (90%), and prominent nucleoli (60%). Twenty percent of cases exhibited all 5 features; 40% exhibited 4 features, and 40% exhibited 3 features. Necrosis and/or mitosis were found in all cases, even in tumors with bland cytologic features. Cytologic, immunophenotypic, and ultrastructural findings should be correlated with clinical and radiologic information for achieving a proper cytologic diagnosis.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Ren R,Guo M,Sneige N,Moran CA,Gong Ydoi
10.1309/AQFEB5WEMU41N9K1subject
Has Abstractpub_date
2006-09-01 00:00:00pages
389-98issue
3eissn
0002-9173issn
1943-7722pii
AQFEB5WEMU41N9K1journal_volume
126pub_type
杂志文章abstract::Histologic follow-up of patients with the Bethesda system cervical-vaginal diagnosis of atypical glandular cells of undetermined significance (AGUS), "favor endocervical origin", or "not otherwise specified" (NOS) shows a high percentage of clinically significant (neoplastic or preneoplastic) lesions. Using the criter...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/107.3.299
更新日期:1997-03-01 00:00:00
abstract::Increasingly, all automated blood counts are not accompanied by a microscopic white blood cell differential. A popular strategy is to obtain a manual differential if any part of the automated blood count and differential is outside specified limits (the "diff-if" strategy). The authors compared two sets of criteria to...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/90.2.163
更新日期:1988-08-01 00:00:00
abstract::Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/M6U4B8L6TNAK4G9L
更新日期:2005-06-01 00:00:00
abstract::The authors investigated the blast cells obtained from two patients with acute myelofibrosis with the use of recently developed immunochemical and ultrastructural markers. They intended to examine the expression of megakaryoblastic, erythroblastic, myeloblastic, and monoblastic properties in these cells. Respectively,...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/83.1.114
更新日期:1985-01-01 00:00:00
abstract::Platelet aggregation studies are usually performed in either electrical impedance or optical systems and the release reaction assessed by quantitating adenosine triphosphate (ATP) from luminesence produced by the firefly luciferin-luciferase system. In evaluating the results of such studies, attention is paid to a var...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/89.5.655
更新日期:1988-05-01 00:00:00
abstract::The authors report the use of cardiac troponin I (cTnI) for the early, noninvasive determination of coronary reperfusion following thrombolytic therapy. Cardiac troponin I, creatine kinase (CK)-MB, and myoglobin concentrations were measured in early serum specimens at 30, 60, and 90 minutes after initiation of therapy...
journal_title:American journal of clinical pathology
pub_type: 临床试验,杂志文章
doi:10.1093/ajcp/105.1.6
更新日期:1996-01-01 00:00:00
abstract::The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8%...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/101.5.559
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVES:We report a case of a patient with diabetes mellitus and unexpectedly low hemoglobin A1c results associated with paroxysmal nocturnal hemoglobinuria (PNH). We review the impact of shortened RBC half-life on the interpretation of hemoglobin A1c levels. METHODS:Patient history and laboratory test results were...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCPTK1HPR2KULJU
更新日期:2014-08-01 00:00:00
abstract::An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies s...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/84.1.1
更新日期:1985-07-01 00:00:00
abstract::FNAB is the most important advance in the management of thyroid nodules in the past two decades. Dr Mazzaferri has said that finding a thyroid cancer in a thyroid nodule is like finding a needle in a haystack. Fine-needle aspiration biopsy is like applying a strong electromagnet to find that needle. It should be avail...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::Characteristically, mantle cell lymphoma (MCL) expresses surface immunoglobulin (sIg), CD19, CD20, and CD5 and lacks CD10 and CD23. Rare CD5-MCL variants have been described. This report describes a case of leukemic MCL with morphologically and immunophenotypically distinct classic MCL and blastoid-variant MCL (BV-MCL...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/UD2C-6JVP-WHXQ-Q217
更新日期:2004-07-01 00:00:00
abstract::A case of metastatic squamous cell carcinoma to bone was studied using immunoperoxidase methods for Factor VIII-related antigen, producing positive staining in the tumor cells. Electron microscopy proved the squamous nature of the tumor, and, subsequently, a pulmonary primary tumor was found. Testing of additional tum...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.1.117
更新日期:1984-01-01 00:00:00
abstract::A test for the detection of antibodies to HTLV-III is available and will be widely used to screen donated blood to prevent transfusion-associated acquired immunodeficiency syndrome (AIDS). Based upon the sensitivity and specificity, the authors calculated the expected predictive values for different groups of asymptom...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/85.6.700
更新日期:1986-06-01 00:00:00
abstract::The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/K7MH8UCK3MR7Q77L
更新日期:2008-09-01 00:00:00
abstract::The combined experience of four university medical centers with fine-needle aspiration biopsy (FNAB) of the mediastinum is reviewed. This series includes 189 cases, with 100 males and 89 females, 6 months to 86 years of age. The majority (71%) of diagnoses were neoplastic with the remainder equally distributed between...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1093/ajcp/105.2.168
更新日期:1996-02-01 00:00:00
abstract::We compared immunohistochemical expression of hepatocyte growth factor (HGF), c-met, alpha-inhibin, estrogen receptor (ER), and progesterone receptor (PR) in 10 pancreatic mucinous cystic neoplasms (PMCNs), 8 hepatobiliary cystadenomas (HBCs), and 6 simple liver cysts (SLCs).All HBCs and PMCNs were in women (mean ages...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/U2BBP4EMBAHCM6E6
更新日期:2008-02-01 00:00:00
abstract::Studies from Africa have demonstrated that black people have higher vitamin B12 (cobalamin) levels than do white people. The authors compared healthy white people, black people, and Latin-Americans in the United States. Their study is also the largest in which the effect of race and sex on the cobalamin levels has bee...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/88.1.95
更新日期:1987-07-01 00:00:00
abstract::A case of septicemia caused by Pseudomonas paucimobilis is reported. This represents the first definitive case of disease produced by this yellow-pigmented, nonfermentative bacillus. ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/72.5.882
更新日期:1979-11-01 00:00:00
abstract::Because T-regulatory cells (Tregs) can harmfully impair HIV-specific responses or beneficially limit immune activation, we compared the number of Tregs in lymph nodes from 48 HIV+ patients and 106 HIV- subjects. By using a microscope counting grid, we found that the mean ± SD number of Tregs in lymph nodes was 3 times...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPAR39BFWNHWRO
更新日期:2011-07-01 00:00:00
abstract::Staphylococcus epidermidis is among the most common organisms isolated from blood cultures. Conversely, it is rarely a well-documented cause of natural-valve endocarditis. However, several authors have reported series of patients with the clinical picture of endocarditis and S. epidermidis bacteremia. Most of these ca...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/87.3.408
更新日期:1987-03-01 00:00:00
abstract:Objectives:Hemolyzed blood samples commonly occur in hospital emergency departments (EDs). Our objective was to determine whether replacing standard large-volume/high-vacuum sample tubes with low-volume/low-vacuum tubes would significantly affect ED hemolysis. Methods:This was a prospective intervention of the use of ...
journal_title:American journal of clinical pathology
pub_type: 临床试验,杂志文章
doi:10.1093/ajcp/aqx082
更新日期:2017-10-01 00:00:00
abstract::This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregati...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPTE3K1SGAPOIZ
更新日期:2009-06-01 00:00:00
abstract::A case of epithelioid sarcoma in a 39-year-old woman who had metastatic lesions in her lung from a primary arm tumor is presented. A review of the literature and analysis of this case did not identify any specific light microscopic or immunohistochemical way to separate definitively the lung cytologic smear in this ca...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/100.2.171
更新日期:1993-08-01 00:00:00
abstract::The use of direct thrombin inhibitors (DTIs) for prophylactic or therapeutic anticoagulation is increasing because of the predictable bioavailability and short half-life of these DTIs. However, in certain situations, indication of the concentration is warranted. We investigated the effects of 3 DTIs (lepirudin, argatr...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPQOD9WFPEYY0H
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To differentiate the leprosy agents Mycobacterium leprae and Mycobacterium lepromatosis and correlate them with geographic distribution and clinicopathologic features. METHODS:Species-specific polymerase chain reactions were used to detect each bacillus in archived skin biopsy specimens from patients with l...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCP1GLCBE5CDZRM
更新日期:2014-10-01 00:00:00
abstract::We studied the presence of surfactant protein A (Sp-A) immunoreactivity and messenger RNA in 62 normal and abnormal breast samples. Sections were immunostained with polyclonal anti-Sp-A antibody. The association between Sp-A immunoreactivity and histologic grade of 32 invasive ductal carcinomas was assessed by 3 patho...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/DU7F-XYP8-1DF6-WM9E
更新日期:2001-11-01 00:00:00
abstract::The authors report a case of primary Ki-1 lymphoma of the brain. The patient was a 4 1/2-year-old black girl who presented with a 4- and 5-day history of headaches, nausea, vomiting, neck stiffness, and difficulty in walking. Computed tomography (CT) scan of the brain showed two discrete densities in the left occipita...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/103.4.496
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVES:Millions of biospecimens will be collected during the coronavirus disease 2019 (COVID-19) pandemic. As learned from severe acute respiratory syndrome (SARS), proper biospecimen handling is necessary to prevent laboratory-related infections. METHODS:Centers for Disease Control and Prevention and World Health...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1093/ajcp/aqaa171
更新日期:2021-01-04 00:00:00
abstract::Fluorescence in situ hybridization (FISH), using repetitive alpha satellite probes to chromosomes 9 and 17, was performed on 27 paraffinembedded bladder specimens from 18 Egyptian patients affected with bilharzial carcinoma. Fluorescence in situ hybridization results in the carcinomas and benign mucosa of patients wit...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/106.2.234
更新日期:1996-08-01 00:00:00
abstract::This, to authors' knowledge, is the first report in the United States of Tinea pedis caused by Trichophyton violaceum in a recent Southeast Asian immigrant. Because of the recent entry into this country of refugees from an area of the world where T. violaceum is endemic, this anthropophilic dermatophyte may become a s...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/80.1.110
更新日期:1983-07-01 00:00:00