Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results.

Abstract:

:The ATHENA (Addressing THE Need for Advanced HPV Diagnostics) HPV study evaluated the clinical usefulness of the cobas HPV Test (Roche Molecular Systems, Pleasanton, CA) for high-risk human papillomavirus (HR-HPV) testing (14 HR types) and individual HPV-16/HPV-18 genotyping in women undergoing routine cervical cytology screening in the United States. For the study, 47,208 women were recruited, including 32,260 women 30 years or older with negative cytology. All women with positive results for HR-HPV (n = 4,219) plus a subset of HR-HPV- women (n = 886) were referred for colposcopy and biopsy. The overall prevalence of HR-HPV was 6.7% and of HPV-16/HPV-18 was 1.5%. Cervical intraepithelial neoplasia grade 2 (CIN 2) or worse was found in 1.2% of women examined. The estimated absolute risk of CIN 2 or worse in HPV-16+ and/or HPV-18+ women was 11.4% (95% confidence interval [CI], 8.4%-14.8%) compared with 6.1% (95% CI, 4.9%-7.2%) in HR-HPV+ and 0.8% (95% CI, 0.3%-1.5%) in HR-HPV- women. These analyses validate the 2006 American Society of Colposcopy and Cervical Pathology guidelines for HPV-16/HPV-18 genotyping, which recommend referral to colposcopy of HPV-16/HPV-18+ women with negative cytology.

journal_name

Am J Clin Pathol

authors

Wright TC Jr,Stoler MH,Sharma A,Zhang G,Behrens C,Wright TL,ATHENA (Addressing THE Need for Advanced HPV Diagnostics) Study Group.

doi

10.1309/AJCPTUS5EXAS6DKZ

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

578-86

issue

4

eissn

0002-9173

issn

1943-7722

pii

136/4/578

journal_volume

136

pub_type

临床试验,杂志文章
  • CAL2 Immunohistochemical Staining Accurately Identifies CALR Mutations in Myeloproliferative Neoplasms.

    abstract:OBJECTIVES:Mutations in CALR (calreticulin) have been discovered in 50% to 80% of JAK2 (Janus kinase 2) and MPL (myeloproliferative leukemia protein) wild-type patients with Philadelphia-negative myeloproliferative neoplasm (MPNs). We evaluate the performance of a monoclonal antibody for immunohistochemical detection o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw135

    authors: Nomani L,Bodo J,Zhao X,Durkin L,Loghavi S,Hsi ED

    更新日期:2016-10-01 00:00:00

  • Extensively keratinized squamous intraepithelial lesions of the cervix are difficult to grade.

    abstract::We tested the hypothesis that extensively keratinized squamous intraepithelial lesions (SILs) are difficult to grade precisely by identifying 100 Papanicolaou smears with a keratinizing SIL that had been originally judged difficult to grade. Of these, 65 were confirmed as low-grade SIL (LSIL) or high-grade SIL (HSIL) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/RQBN-Y51J-CJTK-P9H5

    authors: Faquin WC,Brown FM,Krane JF,Renshaw AA,Cibas ES

    更新日期:2001-01-01 00:00:00

  • Evaluation of commercial enzyme reagent kits by use of a semiautomated chemistry analyzer.

    abstract::The overall performances of several enzyme reagent kits for alkaline phosphatase, creatine kinase, lactic dehydrogenase, and aspartate aminotransferase were evaluated using an ABA-100 Bichromatic Analyzer. Interassay precision using this instrument with commercial reagents compared well with published data for similar...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.2.151

    authors: Beckala HR,Agrell J,Forsman RW,Homburger HA

    更新日期:1979-08-01 00:00:00

  • Theory of network planning for laboratory research and development.

    abstract::Critical Path Method (CPM) and Program Evaluation and Review Technique (PERT) are quantitative network planning strategies that facilitate management of projects with many interrelated activities. They determine the minimum time necessary to complete a project and identify which activities are critical to achieving th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.3.353

    authors: Kost GJ

    更新日期:1983-03-01 00:00:00

  • Esterase activity in erythroleukemia.

    abstract::Specific esterase activity, a property generally ascribed to cells of granulocytic origin, was found in abnormal erythroid precursors obtained from the bone marrows of six patients with untreated erythroleukemia. These erythroblasts also showed nonspecific esterase activity. Neither specific nor nonspecific esterase a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.4.368

    authors: Kass L

    更新日期:1977-04-01 00:00:00

  • Lymphocytic cholecystitis/cholangitis.

    abstract:OBJECTIVES:To describe four cases of an uncommon type of acalculous cholecystitis/cholangitis characterized by increased intraepithelial lymphocytes within the biliary epithelium. METHODS:Cases were prospectively compiled during regular surgical pathology sign-out. Clinical information was obtained from the electronic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP9Q4QWZYYGDNA

    authors: Jessurun J

    更新日期:2015-01-01 00:00:00

  • Amyloid localized to tenosynovium at carpal tunnel release. Natural history of 124 cases.

    abstract::One hundred fifty-two patients with amyloid in the tenosynovium who had carpal tunnel release were identified. Twenty-eight patients were excluded because of systemic amyloidosis: primary systemic amyloidosis (AL) in 24, secondary amyloidosis (AA) in 3, and familial amyloidosis (AF) in 1. The remaining 124 patients (8...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/91.4.393

    authors: Kyle RA,Eilers SG,Linscheid RL,Gaffey TA

    更新日期:1989-04-01 00:00:00

  • Laboratory prediction of the carrier state in hemophilia B: role of replication of assays.

    abstract::The authors studied the effect of averaging replicated assays of Factor IX coagulation activity and Factor IX antigen on each plasma specimen in improving the ability to detect carriers of hemophilia B. The improvement resulting from this procedure is particularly marked in tests depending on the linear regression of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.6.1000

    authors: Lipworth L,Tiarks CY,Rice CA,Pechet L

    更新日期:1979-12-01 00:00:00

  • Comparative performance of three anti-factor Xa heparin assays in patients in a medical intensive care unit receiving intravenous, unfractionated heparin.

    abstract::The availability of automated anti-Xa heparin assays provides the opportunity to manage patient unfractionated heparin levels directly, rather than by the activated partial thromboplastin time. Because critically ill patients can acquire an antithrombin deficiency, we compared the performance of 3 anti-Xa heparin assa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/8E3U7RXEPXNP27R7

    authors: Lehman CM,Rettmann JA,Wilson LW,Markewitz BA

    更新日期:2006-09-01 00:00:00

  • Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?

    abstract:Objectives:Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/aqx134

    authors: Cassidy DP,Vega F,Chapman JR

    更新日期:2017-12-20 00:00:00

  • Detection of methionine in pernicious anemia megaloblasts and other types of erythroid precursors.

    abstract::Utilizing a bacterial-agar overlay technic incorporating the methionine-requiring bacterium Leukonostoc mesenteroides, little or no bacterial growth was seen surrounding the megaloblasts and proerythroblasts of eight patients who had severe untreated pernicious anemia. Similarly, scant bacterial growth was observed in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.4.504

    authors: Kass L

    更新日期:1976-04-01 00:00:00

  • The effects of under 6 hours of formalin fixation on hormone receptor and HER2 expression in invasive breast cancer: a systematic review.

    abstract:OBJECTIVES:A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). METHODS:PubMed, EMBASE, and the Cochra...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCP96YDQSTYBXWU

    authors: Kalkman S,Barentsz MW,van Diest PJ

    更新日期:2014-07-01 00:00:00

  • The clinical significance of eosinophiluria.

    abstract::Eosinophils are normally absent from the urine. Their presence has been associated with a variety of clinical conditions affecting the kidney or urinary tract. The authors examined the clinical significance and eosinophils, in particular, for acute interstitial nephritis. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.4.520

    authors: Corwin HL,Haber MH

    更新日期:1987-10-01 00:00:00

  • Squamous metaplasia of the prostate. An immunohistochemical study.

    abstract::Immunoperoxidase strains for prostate-specific antigen (PSA), prostatic acid phosphatase (PAcP), epithelial membrane antigen (EMA), and cytokeratins (MAK 6 and CK-KES) were performed on 1 case of squamous cell carcinoma of the prostate and on 13 cases of squamous metaplasia of prostatic epithelium in an effort to demo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.5.597

    authors: Lager DJ,Goeken JA,Kemp JD,Robinson RA

    更新日期:1988-11-01 00:00:00

  • Usefulness of DNA ploidy measurement on liquid-based smears showing conflicting results between cytology and high-risk human papillomavirus typing.

    abstract::To improve the positive predictive value (PPV) for high-risk human papillomavirus (HR-HPV) in primary screening, DNA ploidy was measured on the same liquid-based sample by image cytometry in 984 cases showing discrepancies between cytology and HR-HPV testing. Of the conflicting results, 14.5% corresponded to a cytolog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/6NXC-V9XD-YM87-8FAE

    authors: Lorenzato M,Bory JP,Cucherousset J,Nou JM,Bouttens D,Thil C,Dez F,Evrard G,Quereux C,Birembaut P,Clavel C

    更新日期:2002-11-01 00:00:00

  • Serum uric acid.

    abstract::Data from the 1977 College of American Pathologists (CAP) Comprehensive Chemistry Survey and other programs have been analyzed in an interlaboratory comparison of the measurements of serum uric acid. The majority of clinical laboratories utilize some form of phosphotungstic acid (PTA) oxidation-reduction technic for t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Geisinger KR,Batsakis JG,Bauer RC

    更新日期:1979-08-01 00:00:00

  • Squamous cell carcinoma variants of the upper aerodigestive tract.

    abstract::Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract. Most conventional-type SCCs do not present the surgical pathologist with diagnostic difficulty. Certain variants, however, can histologically mimic benign and other malignant diseases. In such cases, correct diagnosis ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/CR5JXUY3J2YGTC1D

    authors: Stelow EB,Mills SE

    更新日期:2005-12-01 00:00:00

  • Serum percent-free PSA does not predict extraprostatic spread of prostate cancer.

    abstract::Percent-free prostate-specific antigen (proportion of free prostate-specific antigen [PSA] to total PSA) has been shown recently in studies on frozen serum samples to be more useful than total PSA alone in distinguishing prostate cancer from benign conditions of the prostate gland. The primary purpose of our study was...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.5.533

    authors: Henricks WH,England BG,Giacherio DA,Oesterling JE,Wojno KJ

    更新日期:1998-05-01 00:00:00

  • Preventing Genetic Testing Order Errors With a Laboratory Utilization Management Program.

    abstract:OBJECTIVES:To characterize error rates for genetic test orders between medical specialties and in different settings by examining detailed order information. METHODS:We performed a retrospective analysis of a detailed utilization management case database, comprising 2.5 years of data and almost 1,400 genetic test orde...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw105

    authors: Mathias PC,Conta JH,Konnick EQ,Sternen DL,Stasi SM,Cole BL,Astion ML,Dickerson JA

    更新日期:2016-08-01 00:00:00

  • Ochronosis in the breast.

    abstract::A patient who had masses in the breasts clinically suggestive of neoplasia had fibrous mastopathy and striking deposition of ochronotic pigment within the soft tissue of the breast. The gross appearance and light microscopic features are illustrated. The histochemical features of ochronotic pigment and the difficulty ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.3.349

    authors: Lefer LG,Rosier RP

    更新日期:1979-03-01 00:00:00

  • Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision.

    abstract::Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP1D8YLCFFTLOW

    authors: Sutton B,Davion S,Feldman M,Siziopikou K,Mendelson E,Sullivan M

    更新日期:2012-12-01 00:00:00

  • The effect of media and temperature on the storage of Chlamydia trachomatis.

    abstract::Four media, Eagle's minimal essential medium with 10% fetal bovine serum (MEM/FBS), tryptic soy broth (TSB), 2-SP, and 4-SP, were compared for their ability to maintain the viability of Chlamydia trachomatis at 4 degrees C, -20 degrees C, -70 degrees C, and -176 degrees C (liquid nitrogen) over a 1-week period. 2-SP m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.2.237

    authors: Aarnaes SL,Peterson EM,De La Maza LM

    更新日期:1984-02-01 00:00:00

  • Cancer tracking: Clinician compliance and program outcome.

    abstract:OBJECTIVES:Certain laboratory tests are critical for patient care and must be communicated rapidly. Professional societies have developed guidelines for reporting of "critical values" and significant or unexpected surgical pathology findings. Urgent diagnoses requiring rapid reporting include new or unexpected diagnose...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPJHFVORM48IZL

    authors: Layfield LJ,Schnabel JL

    更新日期:2014-12-01 00:00:00

  • Improving quality of patient care in an emergency department: a laboratory perspective.

    abstract::The purpose of our study was to improve the quality of care in an emergency department (ED) as measured by length of stay (LOS), total turnaround time (TAT) for laboratory result reporting, and the blood culture contamination rate. Data were included for patients who had at least 1 of 5 laboratory tests performed as p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DGXYTH0VNTTQRQHD

    authors: Sheppard C,Franks N,Nolte F,Fantz C

    更新日期:2008-10-01 00:00:00

  • Are autopsies obsolete?

    abstract::To determine the current frequency of discovering important diagnoses at autopsy, the diagnoses made in all complete or "no head" autopsies during 1994 at a major tertiary care transplantation referral center were retrospectively compared with the diagnoses made antemortem. Of 176 autopsies, 79 (44.9%) revealed 1 or m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.2.210

    authors: Nichols L,Aronica P,Babe C

    更新日期:1998-08-01 00:00:00

  • Mucosal pseudolipomatosis of the colon.

    abstract::Twenty-four cases of a lesion characterized by unlined spaces in the colorectal lamina propria are presented. While lesions such as this have been reported previously as "lipomatosis" of the colon, histochemical and ultrastructural examination reveals that they are not, in fact, composed of adipocytes. It appears that...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.5.575

    authors: Snover DC,Sandstad J,Hutton S

    更新日期:1985-11-01 00:00:00

  • Rapid thawing of fresh frozen plasma.

    abstract::Fresh frozen plasma (FFP) normally requires about 45 min to thaw in a 37 degrees C water bath when placed inside an additional plastic overbag. That relatively prolonged time may result in non-utilization or delays in delivery of the product, especially, during emergency surgery. One report recommends the use of a mic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.2.220

    authors: Westphal RG,Tindle B,Howard PL,Golden EA,Page GA

    更新日期:1982-08-01 00:00:00

  • Primary lymphadenopathic Kaposi's sarcoma in an immunocompetent 23-year-old man.

    abstract::An aggressive visceral form of Kaposi's sarcoma (KS) has been reported in immunosuppressed populations, most notably in patients with acquired immunodeficiency syndrome (AIDS). This presentation contrasts from the indolent skin lesions on the extremities of older males and is distinct enough in the young adult America...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.3.366

    authors: Berman MA,Nalesnik MA,Kapadia SB,Rinaldo CR Jr,Jensen F

    更新日期:1986-09-01 00:00:00

  • Molecular Genetic Landscape of Sclerosing Pneumocytomas.

    abstract:OBJECTIVES:Sclerosing pneumocytomas are rare pulmonary neoplasms that are typically benign. However, rare patients experience progressive disease, and therapy targeting specific genetic underpinnings could be an attractive therapeutic option. Recent studies have found recurrent AKT 1 mutations in sclerosing pneumocytom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa136

    authors: Boland JM,Lee HE,Barr Fritcher EG,Voss JS,Jessen E,Davila JI,Kipp BR,Graham RP,Maleszewski JJ,Yi ES

    更新日期:2020-11-04 00:00:00

  • American Burkitt's lymphoma-hand-mirror variant. A detailed investigation of cytologic, ultrastructural, and immunologic features.

    abstract::Previous studies of patients with lymphoid malignancies have suggested a relationship between survival and the presence of more than 40% hard-mirror cells in the bone marrow. This report represents the first detailed study of a patient with American Burkitt's lymphoma with numerous hand-mirror cells in the bone marrow...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.6.937

    authors: Schumacher HR,Rainey T,Davidson L,Simon D,Strong M,Creegan WJ,Holloway ML,Stass SA

    更新日期:1978-12-01 00:00:00