Squamous cell carcinoma variants of the upper aerodigestive tract.

Abstract:

:Squamous cell carcinoma (SCC) is by far the most common malignancy of the upper aerodigestive tract. Most conventional-type SCCs do not present the surgical pathologist with diagnostic difficulty. Certain variants, however, can histologically mimic benign and other malignant diseases. In such cases, correct diagnosis is important for prognostic and therapeutic reasons. This article discusses the clinicopathologic features of the upper aerodigestive tract variants of SCC, including verrucous carcinoma, papillary squamous cell carcinoma, basaloid squamous cell carcinoma, spindle cell carcinoma, adenosquamous carcinoma, adenoid squamous cell carcinoma, and undifferentiated carcinoma. It also discusses the differential diagnoses that must be considered and the use of ancillary testing, especially immunohistochemical analysis, for determining the correct diagnosis.

journal_name

Am J Clin Pathol

authors

Stelow EB,Mills SE

doi

10.1309/CR5JXUY3J2YGTC1D

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

S96-109

eissn

0002-9173

issn

1943-7722

journal_volume

124 Suppl

pub_type

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