Amyloid localized to tenosynovium at carpal tunnel release. Natural history of 124 cases.

Abstract:

:One hundred fifty-two patients with amyloid in the tenosynovium who had carpal tunnel release were identified. Twenty-eight patients were excluded because of systemic amyloidosis: primary systemic amyloidosis (AL) in 24, secondary amyloidosis (AA) in 3, and familial amyloidosis (AF) in 1. The remaining 124 patients (82%) had carpal tunnel syndrome with local deposition of amyloid and no evidence of systemic amyloidosis. Median survival of the 124 patients from diagnosis of amyloidosis was 12 years. Only two patients had systemic amyloidosis develop--9 and 10 years after recognition of tenosynovial amyloid. Of particular interest were 12 patients who had an M-protein in the serum or urine. None of the 12 patients have had evidence of systemic amyloidosis or multiple myeloma during the median follow-up of 14 years. The authors conclude that amyloid may be localized to the tenosynovium and that systemic amyloidosis rarely develops during long-term follow-up.

journal_name

Am J Clin Pathol

authors

Kyle RA,Eilers SG,Linscheid RL,Gaffey TA

doi

10.1093/ajcp/91.4.393

subject

Has Abstract

pub_date

1989-04-01 00:00:00

pages

393-7

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

91

pub_type

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