Abstract:
:We compared the differential counts of normal and abnormal bone marrow from touch imprints with those from aspirate smears to determine whether the touch imprint was reliable for independent routine use in the examination of bone marrow and the classification of hematologic abnormalities. Normocellular bone marrow specimens were obtained from 87 patients without hematologic abnormality. Abnormal bone marrow specimens were obtained from 173 patients with treated or untreated neoplastic hematologic disease, including acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia, non-Hodgkin lymphoma, hairy cell leukemia, myeloma, and acute lymphoblastic leukemia. We found no diagnostic difference in the differential counts from touch imprints and aspirate smears of normocellular bone marrow, and although we found some difference between the differential counts in certain cases of diseased bone marrow, the touch imprint proved to be a reliable diagnostic tool for determining the cellular composition of normal bone marrow and more reliable for the diagnosis of bone marrow involved by a neoplastic hematologic disease. Our findings suggest that evaluating touch imprints should be considered a standard practice in examining bone marrow.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Aboul-Nasr R,Estey EH,Kantarjian HM,Freireich EJ,Andreeff M,Johnson BJ,Albitar Mdoi
10.1093/ajcp/111.6.753subject
Has Abstractpub_date
1999-06-01 00:00:00pages
753-8issue
6eissn
0002-9173issn
1943-7722journal_volume
111pub_type
杂志文章abstract::The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8%...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/101.5.559
更新日期:1994-05-01 00:00:00
abstract::In order to further clarify the histologic criteria and prognostic measurement of appendiceal adenoma and well differentiated adenocarcinoma, lectin binding activity in 31 cases of appendiceal mucocele (6 hyperplasias, 16 adenomas and 9 adenocarcinomas) was studied using an immunoperoxidase staining method. An additio...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/89.4.481
更新日期:1988-04-01 00:00:00
abstract::Because of the unusual presentation of pernicious anemia in many black women, a further characterization of this disease among the different racial groups was undertaken. The following were found. (1) Black women under the age of 50 years had a significantly lower prevalence of anti-parietal cell antibody than did "Eu...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/75.3.291
更新日期:1981-03-01 00:00:00
abstract::Estrogen receptor (ER) status of breast carcinomas determines prognosis and treatment. Biochemical ER assays are expensive and time-consuming and require fresh tumor. Immunohistochemical ER was assessed in 68 breast carcinomas, by an automated method using routinely processed formalin-fixed paraffin-embedded tissues, ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/92.5.669
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVES:To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). METHODS:The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. RESULTS:The patients with MCL-MZGP typically sought treatment at high clinical stages (...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqz043
更新日期:2019-07-05 00:00:00
abstract::To investigate the specificity of terminal deoxynucleotidyl transferase (TdT) as a marker for lymphoblastic lymphoma in the non-Hodgkin's lymphomas, the authors assayed malignant cells from 142 patients with non-Hodgkin's malignant lymphoma, as well as cells from normal lymphoid tissue controls. Neoplastic cells from ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/80.5.655
更新日期:1983-11-01 00:00:00
abstract::Platelet function testing is important for the diagnostic evaluation of common and rare bleeding disorders. Our study goals were to promote best practices and reduce unnecessary testing variances by developing North American guidelines on platelet function testing. Guidelines were developed by consensus for expert rec...
journal_title:American journal of clinical pathology
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1309/AJCP9V3RRVNZMKDS
更新日期:2010-12-01 00:00:00
abstract::Monoclonal antibody (MoAb) 44-3A6 recognizes a glandular differentiation-associated antigen and has been used to identify exocrine differentiation in pulmonary carcinomas. The authors assessed its value in the diagnosis of lung carcinomas metastatic to lung/pleura and pleural malignant mesothelioma (MM), using cell bl...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/95.3.322
更新日期:1991-03-01 00:00:00
abstract::A rapid, convenient immunologic assay technic for fibrinogen is reported. Basically a latex agglutination, the assay technic, called kinetic latex agglutinometry, quantitates the increase in light transmission that occurs in a stirred suspension of anti-fibrinogen-coated latex beads after the addition of a plasma or w...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/77.4.424
更新日期:1982-04-01 00:00:00
abstract::DNA sequencing was used to confirm Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acids in endocervical swab samples. DNA in residues of the samples with positive results by 2 commercial kits was subjected to nested polymerase chain reaction (PCR) amplification. The nested PCR amplicons were used as templates...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/Y2202RVCGRWW1RWB
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:Increased frequency of hyperamylasemia has previously been reported in human immunodeficiency virus (HIV)-positive patients, but studies determined total amylase activity and were performed before the introduction of highly active antiretroviral therapy (HAART). We evaluated the frequency of pancreatic hyper...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqv020
更新日期:2016-01-01 00:00:00
abstract::Five patterns of bone marrow infiltration by non-Hodgkin lymphoma or Hodgkin lymphoma are currently recognized, but a true follicular pattern of bone marrow involvement by follicular lymphoma has not been described. In 260 bone marrow trephine biopsy specimens involved by follicular lymphoma, we identified 12 cases wi...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/EG2M-YHB9-WEFW-7H1R
更新日期:2002-11-01 00:00:00
abstract::Nineteen patients with acute nonlymphocytic leukemia were found to have a pericentric inversion of chromosome 16. All were classified as having acute myelomonocytic leukemia (M4) according to French-American-British Cooperative Group (FAB) criteria. Consistent abnormalities of marrow eosinophils were present. In 15 of...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.6.733
更新日期:1984-06-01 00:00:00
abstract::We compared a rapid, point-of-care multimarker protocol with a single and serial troponin I (TnI)-only protocol in 5,244 patients admitted to the emergency department with chest pain. The diagnosis of acute myocardial infarction (AMI) was based on a doubling myoglobin level accompanied by at least a 50% increase in th...
journal_title:American journal of clinical pathology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1309/9GGNMURLJWJD88W3
更新日期:2008-05-01 00:00:00
abstract::The May-Hegglin anomaly is one of the rare forms of heriditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/74.5.663
更新日期:1980-11-01 00:00:00
abstract::Breast cancer in men is a rare condition affecting only 1,000 men each year in the United States. Hormonal, genetic, and perhaps environmental factors appear to be important in development of the disease. Clinically, breast cancer in men resembles that seen in woman. Histologically the diseases are indistinguishable, ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::Immunoperoxidase technics were used to examine the immunoglobulin content of sections of pulmonary tissue from two typical cases of lymphomatoid granulomatosis and two cases of pneumonic processes initially diagnosed as lymphomatoid granulomatosis but representing different processes on review. Both "typical" cases an...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/73.1.41
更新日期:1980-01-01 00:00:00
abstract::In a case of secondary syphilis with gastric involvement, the clinical history and roentgenographic and gastroscopic examiniations initially suggested an infiltrative malignant neoplasm. However, macroscopic and histologic examination of the partial gastrectomy specimen demonstrated an erosive, inflammatory lesion. Su...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/63.6.895
更新日期:1975-06-01 00:00:00
abstract::The expression of HLA class I antigens in testicular germ cell tumors (TGCTs) was studied by the immunoperoxidase technique. In the normal testicle, the interstitial cells of Leydig as well as most of the germ cells were significantly stained. In typical seminoma, 75% of the tumor cells in stage I and 30% in stage II ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/93.2.202
更新日期:1990-02-01 00:00:00
abstract::Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract::Extramammary Paget disease (EPD) is an uncommon cutaneous malignant neoplasm that arises in areas rich in apocrine glands (perineum, vulva, and axilla). Apocrine gland origin or apocrine differentiation of cells of EPD has been suggested. Estrongen, progesterone, and androgen hormone receptors have been reported to ex...
journal_title:American journal of clinical pathology
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更新日期:2000-04-01 00:00:00
abstract::The nephrotic syndrome has long been recognized as a hypercoagulable state. Arterial thrombosis is a rare complication of the syndrome. Diuretics and steroids, standard treatment for exacerbations, have been implicated as contributing to the development of arterial thrombosis. The authors present the pathologic, clini...
journal_title:American journal of clinical pathology
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更新日期:1994-02-01 00:00:00
abstract::An automated calcium method based on o-cresolphthalein complexone chemistry and designed to be used in conjunction with the Beckman ASTRA systems (Beckman Instruments, Inc., Brea, CA) was evaluated. Day-to-day reproducibility studies yielded coefficients of variation ranging from 1.2 to 3.1%. Linearity was 5.0-15.5 mg...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
abstract::Seven monoclonal antibodies of rat origin were generated against human epidermal keratins and were assayed by immunoblot and by immunoperoxidase staining of frozen sections from various human epithelial tissues. By immunoblotting, the antibodies recognized two different subsets of high molecular weight cytokeratin pol...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1988-03-01 00:00:00
abstract::Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/HPYG-FLNX-KFBH-DQEV
更新日期:2006-07-01 00:00:00
abstract::Fourteen patients treated by allogeneic bone marrow transplantation for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr-abl-specific transcripts. Nine patients were transplanted in the first chronic phase, three in the second chronic phase, and two in the accelerated ph...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/104.5.510
更新日期:1995-11-01 00:00:00
abstract::Chemotherapy is a well-established therapeutic approach for several malignancies, but its clinical efficacy is often limited by its related cardiotoxicity, which leads to cardiomyopathy, possibly evolving into heart failure. To detect cardiac damage, the adopted diagnostic approach is the estimation of left ventricula...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCPB66LRIIVMQDR
更新日期:2008-11-01 00:00:00
abstract::Pseudo-Pelger-Huët anomaly (PPHA) has been documented in association with transplant medications and other drugs. This iatrogenic neutrophilic dysplasia is reversible with cessation or adjustment of medications but is frequently confused with myelodysplastic syndrome (MDS) based on the conventional concept that PPHA i...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:2011-02-01 00:00:00
abstract::The aim of the present study was to determine whether micromorphometric features of positive sentinel lymph nodes (SLNs) from patients with melanoma are useful for predicting further nodal involvement in completion lymph node dissection (CLND) specimens. Of 986 patients with melanoma undergoing SLN biopsy between Marc...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/TDWJ-TR15-TDM1-TG7Q
更新日期:2004-10-01 00:00:00
abstract::A 37-year-old intravenous drug abuser with acquired immune deficiency syndrome showed elevated activated partial thromboplastin time (APTT) and prothrombin time, normal thrombin time and fibrinogen, and borderline low platelet counts. The patient subsequently had a fracture of the left zygomatic arch, which did not pr...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/91.4.491
更新日期:1989-04-01 00:00:00