Antithrombin III and Factor VIII in patients with neoplasms.

Abstract:

:Possible increased activation of the coagulation pathway was measured in a group of patients with neoplastic diseases. In addition to standard tests, the thromboplastin generation test, thrombin generation test and immunologic and coagulant activities of both Factor VIII and antithrombin III were utilized in the evaluation. The correlation between immuno-Factor VIII (VIII-Ag) and its clotting activity (VIII-C1) was good (r = 0.83). In contrast, this was not the situation for antithrombin III-Ag and its clotting activity. Thromboplastin generation was accelerated in 60% and thrombin generation was accelerated in 40% of the patients. Fibrinogen was elevated in half the cases: in most of these patients, thrombin times were slightly prolonged. These results indicate that some patients who have cancer have abnormal clotting patterns and are often in a potentially hypercoagulable state that is reflected by the thromboplastin generation test, thrombin generation test, and high levels of Factor VIII (both VIII-Ag and VIII-C1).

journal_name

Am J Clin Pathol

authors

Losito R,Beaudry P,Valderrama JC,Cousineau L,Longpré B

doi

10.1093/ajcp/68.2.258

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

258-62

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

68

pub_type

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